Biomechanics of accommodation

住宿生物力学

• 批准号: 10441503
• 负责人: Kirill V Larin
• 金额: $ 58.2万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441503
• 关键词: Age; Anatomy; Animals; Biomechanics; Biometry; Clinic; Clinical; Coupling; Crystalline Lens; Custom; Data; Development; Devices; Elasticity; Eye; Goals; Human; Imaging Device; Investigation; Knowledge; Lens development; Measurable; Measurement; Measures; Mechanics; Methods; Microscopy; Modality; Monitor; Optical Coherence Tomography; Optical Instrument; Optics; Oryctolagus cuniculus; Outcome; Physiology; Preclinical Testing; Presbyopia; Procedures; Quality of life; Research Design; Retreatment; Role; Stress; Stretching; Surface; System; Techniques; Technology; Testing; Therapeutic procedure; Time; Tissues; Treatment outcome; Validation; Vision; age related; biomechanical model; design; elastography; functional outcomes; human subject; image guided; in vivo; instrument; instrumentation; lens; mechanical properties; multidisciplinary; multimodality; new technology; novel; preservation; research clinical testing; treatment effect; treatment optimization

PROJECT ABSTRACT Presbyopia, the progressive age-related loss of near visual function, is associated with a stiffening of the crystalline lens. There are currently several investigational approaches for presbyopia treatment that rely on lens softening or lens replacement with softer materials. Lens softening approaches are expected to have a transformative impact on the field because they are non-invasive and they preserve the anatomical relationship between the lens and other tissues involved in accommodation. They have therefore the potential to restore the natural dynamic accommodative function. However, one of the fundamental roadblocks towards the development of lens softening procedures is that there is currently no method available to directly measure lens stiffness and thus assess the efficacy of lens softening procedures in vivo. The goal of the project is to develop new technology capable of precise spatially-resolved non-destructive, noninvasive and depth-resolved quantitative measurements of the lens mechanical properties in a clinical setting. The technology will combine Brillouin microscopy, Optical Coherence Tomography (OCT), and Optical Coherence Elastography (OCE) - BOE. The instrument will be used to generate the first age-dependent data on lens mechanical properties quantified in vivo as well as quantitatively assess therapeutic procedures aimed to restore accommodation. Our overall hypothesis is that the novel BOE technology can acquire absolute measurements of the lens stiffness gradient with the accuracy and precision required to detect both age-related changes and changes induced by lens softening treatments. The ability to quantify lens softening in vivo will have a major impact on pre-clinical and clinical testing, validation and optimization of lens softening procedures. The project has three specific aims: Aim 1: Develop a combined BOE imaging device for depth-resolved quantitative lens elastography. Aim 2: Validate BOE measurements in animal and human lens ex vivo and animal lens in vivo. Aim 3: Quantify the mechanical properties of the human lens in vivo To accomplish our objective, we have assembled a multidisciplinary team with expertise in optical coherence tomography and elastography (Larin), Brillouin technology (Scarcelli), biomechanical modeling (Aglyamov), clinical ophthalmic instrumentation and crystalline lens physiology (Manns, Parel, Ruggeri, Yoo).

项目摘要 长老会是渐进的年龄相关的近乎视觉功能的丧失，与僵硬 结晶镜头。目前有几种依赖晶状体的长期治疗方法 用柔软的材料替换软化或镜头。镜头软化方法有望具有 对现场的变革性影响是因为它们是非侵入性的，并且保留了解剖学关系 镜头和其他涉及适应性的组织之间。因此，他们有可能恢复 自然动态适应性功能。但是，朝向的基本障碍之一 透镜软化程序的开发是目前尚无可直接测量镜头的方法 刚度，从而评估体内晶状体软化程序的功效。 该项目的目的是开发能够精确的空间分辨的非破坏性的新技术 临床中晶状体机械性能的无创和深度分辨定量测量 环境。该技术将结合Brillouin显微镜，光学相干断层扫描（OCT）和光学 相干弹性图（OCE）-BOE。该仪器将用于生成第一个与年龄有关的数据 透镜机械性能在体内量化，并定量评估旨在的治疗程序 恢复住宿。 我们的总体假设是，新颖的BOE技术可以获得晶状体刚度的绝对测量 梯度具有检测年龄相关的变化所需的精度和精度 透镜软化处理。量化体内晶状体软化的能力将对临床前产生重大影响 以及镜头软化程序的临床测试，验证和优化。 该项目具有三个特定的目标： AIM 1：开发一个组合的BOE成像装置，以进行深度分辨定量透镜弹性图。 AIM 2：验证体内动物和人透镜的BOE测量值。 目标3：量化体内人镜头的机械性能 为了实现我们的目标，我们组建了一个具有光学连贯性专业知识的多学科团队 层析成像和弹性学（拉林），布里鲁因技术（Scarcelli），生物力学建模（Aglyamov）， 临床眼科仪器和晶体晶状体生理学（Manns，Parel，Ruggeri，Yoo）。