Chronic Kidney Disease in Children (CKiD V)

儿童慢性肾脏病 (CKiD V)

基本信息

批准号：
10731013
负责人：
Bradley Alan Warady
金额：
$ 116.62万
依托单位：
CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10731013
关键词：
17 year old Acceleration Achievement Acute Renal Failure with Renal Papillary Necrosis Address Adolescence Adolescent Adolescent and Young Adult Adult Affect African American Age Ancillary Study Behavioral Biological Markers Birth Blood Pressure Blood Vessels Canada Cardiac Cardiovascular Abnormalities Cardiovascular Diseases Caring Cellular Phone Child Child Welfare Childhood Chronic Kidney Failure Chronic Phase Clinical Clinical Markers Clinical Research Cohort Studies Collaborations Communities Computers Contractor DNA Data Data Collection Development Diagnosis Dialysis procedure Disease Disease Outcome Disease Progression Education Electronic Health Record Eligibility Determination Emotional Enrollment Ensure Equation Evaluation Event Family Functional disorder Genetic study Glomerular Filtration Rate Goals Health Healthcare Systems Heart Atrium High Prevalence Home Home Blood Pressure Monitoring Individual Information Systems International Joints Kidney Kidney Diseases Kidney Transplantation Laboratories Leadership Left Life Cycle Stages Link Machine Learning Measurement Measures Metabolic Metabolic Bone Diseases Metabolic Marker Methodology Methods Midwestern United States Monitor Myocardial Myocardium Natural History Nephrology Neurocognitive North America Online Systems Organ Outcome Participant Patient Recruitments Performance Persons Plasma Population Predictive Value Principal Investigator Process Puberty Publications Quality of life Readiness Relaxation Renal Replacement Therapy Renal function Reporting Research Research Personnel Research Priority Resources Risk Risk Assessment Risk Factors Role Serum Severities Site Social Functioning Source Standardization Statistical Methods Structure Symptoms Training Urine Ventricular Visit Well in self Writing Youth biobank bone health calcification cardiovascular disorder risk cardiovascular risk factor clinical care clinical center clinical phenotype cohort coronary artery calcium design disease diagnosis electronic data capture system ethnic diversity follow-up functional decline hypertension treatment improved indexing machine learning prediction male mortality novel patient retention racial diversity recruit social determinants time interval validation studies virtual young adult

项目摘要

PROJECT SUMMARY/ABSTRACT For the Chronic Kidney Disease in Children (CKiD) Study renewal, we will continue to follow our existing cohort, and will recruit children between 14 and 17 years of age to enhance the power of the study to characterize the decline of kidney function and the development of cardiovascular disease as they transition to young adulthood. Remote data collection will be coordinated and conducted through national laboratory contractors who can assess vitals and obtain labs in the participant’s home. Data will be obtained between CKiD study visits by conducting data extraction through electronic health records. The Research Electronic Data Capture (REDCap) system will be leveraged to allow automated reporting for coordination and clinical activities and improve options for harmonization with external cohorts including CureGN and NEPTUNE. Most importantly, it will enable the study to collect data through web-based entry by computer or mobile phone directly by participants. Important research questions will include (a) methods to identify risk factors for decline in kidney function during childhood through young adulthood including acceleration of glomerular filtration rate (GFR) decline during puberty and the effect of acute kidney injury (AKI) on chronic kidney disease (CKD); (b) statistical-based machine learning prediction methodology to characterize the joint predictive value of clinical markers and social determinants of disease progression for individualized inference; (c) analytic strategies to describe risk factors for cardiovascular changes and outcomes via home blood pressure monitoring and assessing cardiac and vascular target organ damage, including characterizing changes in biomarkers like trajectories of indicators of metabolic bone health; (d) statistical methods to validate and refine GFR equations in young adulthood for consistent estimates during the transition from pediatric to adult care; and (e) methods to assess effects of therapies and exposures on outcomes including constructs of social function and emotional well-being.

项目概要/摘要为了更新儿童慢性肾脏病 (CKiD) 研究，我们将继续跟踪现有队列，并将招募14至17岁之间的儿童，以增强研究的力量来表征当他们过渡到成年早期时，肾功能会下降，心血管疾病也会发生。远程数据收集将通过国家实验室承包商进行协调和进行，他们可以评估生命体征并获取参与者家中的实验室数据将在 CKiD 研究访问期间获得。通过电子健康记录进行数据提取（REDCap）。将利用系统来实现协调和临床活动的自动报告并改进选项与包括 CureGN 和 NEPTUNE 在内的外部团队协调一致。最重要的是，它将实现研究通过电脑或手机直接通过网络录入来收集数据。重要的研究问题将包括（a）确定肾功能下降风险因素的方法童年期到青年期，包括肾小球滤过率 (GFR) 加速下降青春期以及急性肾损伤（AKI）对慢性肾病（CKD）的影响；（b）基于统计的机器；学习预测方法来表征临床标志物和社会标志物的联合预测价值 (c) 描述风险因素的分析策略通过家庭血压监测和评估心血管变化和结果血管靶器官损伤，包括表征生物标志物的变化，如指标轨迹代谢性骨骼健康；(d) 验证和完善青年期 GFR 方程的统计方法从儿科护理过渡到成人护理期间的一致估计；以及 (e) 评估效果的方法治疗和暴露结果，包括社会功能和情绪健康的构建。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Risk factors for progression of chronic kidney disease.

DOI：
10.1097/mop.0b013e328336ebb0
发表时间：
2010-04
期刊：
Current opinion in pediatrics
影响因子：
3.6
作者：
Staples A;Wong C
通讯作者：
Wong C

Response to: echocardiography assessment of the aorta in children with chronic kidney disease.

反应：慢性肾病儿童主动脉的超声心动图评估。

DOI：
发表时间：
2014
期刊：
Pediatric cardiology
影响因子：
1.6
作者：
Alghamdi,M;DeSouza,AM;White,CT;Potts,MT;Warady,BA;Furth,SL;Kimball,TR;Potts,JE;Sandor,GG
通讯作者：
Sandor,GG

Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study.

DOI：
10.1016/j.ekir.2022.08.002
发表时间：
2022-11
期刊：
KIDNEY INTERNATIONAL REPORTS
影响因子：
6
作者：
Bakhoum, Christine Y.;Phadke, Manali;Deng, Yanhong;Samuels, Joshua A.;Garimella, Pranav S.;Furth, Susan L.;Wilson, F. Perry;Ix, Joachim H.
通讯作者：
Ix, Joachim H.

Dialysis: Vascular access in children--arteriovenous fistula or CVC?

透析：儿童血管通路——动静脉瘘还是CVC？