Chronic Kidney Disease in Children (CKiD III)

儿童慢性肾脏病 (CKiD III)

基本信息

批准号：
8581783
负责人：
Bradley Alan Warady
金额：
$ 95.59万
依托单位：
CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8581783
关键词：
11 year old Acidosis Acute Renal Failure with Renal Papillary Necrosis Address Adverse effects African American Albuminuria Ancillary Study Anemia Attention Behavior Biological Markers Birth History Blood Pressure Canada Cardiac Cardiovascular Diseases Child Childhood Chronic Kidney Failure Cities Classification Clinical Clinical Research Clip Cohort Studies Collaborations Controlled Study Data Data Coordinating Center Development Diagnosis Disease Disease Progression Enrollment Environmental Exposure Etiology Failure Functional disorder Funding Future Gestational Diabetes Goals Gold Growth Growth and Development function Hair Healthcare Systems Heart Diseases Height High Prevalence Hospitals Hypertension Hypoalbuminemia Individual Injury International Intervention K-Series Research Career Programs Kansas Kidney Kidney Diseases Laboratories Low Birth Weight Infant Magnetic Resonance Imaging Measurement Measures Morbidity - disease rate Myocardial Neonatal Nephrology Neurocognitive Newborn Infant North America Outcome Participant Pediatric Hospitals Performance Perinatal Philadelphia Physiologic pulse Plasma Play Potassium Phosphate Prevalence Principal Investigator Procedures Process Prospective Studies Proteinuria Public Health Schools Quality Control Quality of life Race Recording of previous events Recruitment Activity Renal function Renal glomerular disease Reporting Research Design Research Infrastructure Research Personnel Risk Risk Factors Role Sampling Sepsis Site Smoking History Structure Structure of nail of finger Structure of nail of toe Therapeutic Intervention Therapy Clinical Trials U-Series Cooperative Agreements United States National Institutes of Health Universities Urine Visit Weight Gain Youth aged arterial stiffness cardiovascular disorder risk cognitive function cohort executive function follow-up genome wide association study improved maternal cigarette smoking meetings member mortality novel novel strategies prenatal prospective public health relevance young adult

项目摘要

DESCRIPTION (provided by applicant): The Chronic Kidney Disease in Children Study (CKiD) is a multi-center, prospective cohort study of children aged 1 to 16 years with mild to moderately impaired kidney function at study entry. Two clinical coordinating centers (CCCs) (at the Children's Hospital of Philadelphia (CHOP), and Children's Mercy Hospital (CMH) in Kansas City), a central laboratory (at the University of Rochester), and a data coordinating center (at Johns Hopkins Bloomberg School of Public Health) have formed a cooperative agreement to conduct this prospective study of chronic kidney disease in children. Since its inception in 2003, the scientific aims of CKiD have been to determine the risk factors for decline in kidney function and the effects of kidney function decline on risk factors for cardiovascular disease; growth failure and its associated morbidity; and neurocognitive function and behavior. The purpose of this application is to request funds to continue the cohort study from August, 2013 to July, 2018. The aims of the current proposal are to assess and improve the accuracy and precision of the CKiD estimating formulas in youth with early CKD, to define the risk of kidney disease progression in children according to the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD according to Cause, GFR and level of albuminuria, to define risk factors for accelerated and non-linear decline in GFR among strata of children with glomerular compared to non-glomerular diagnoses and in African Americans, and to assess physical performance, arterial stiffness and myocardial structure and function as GFR declines. The Midwest Clinical Coordinating Center Principal Investigator has clinical expertise in kidney disease in children, clinical research design, recruitment and retention, quality control of study procedures, and organization of collaboration across the multiple participating sites in CKiD. The CKiD study encompasses a geographically and racially diverse cohort. The structure of CKiD and its support of ancillary studies continue to stimulate novel approaches to identify risk factors for kidney disease progression. The infrastructure of CKiD continues to serve as a platform for career development awards for junior investigators and ancillary R01's for more senior colleagues. With longer follow-up and additional recruitment of subjects with mild kidney dysfunction and glomerular disease, we will continue to characterize novel biomarkers of kidney injury that are associated with CKD progression and its sequellae to inform future therapeutic trials.

描述（由申请人提供）：儿童研究（CKID）的慢性肾脏疾病是一项多中心的前瞻性队列研究，对1至16岁的儿童患有轻度至中度受损的肾脏功能在研究入学时。两个临床协调中心（CCCS）（在费城儿童医院（CHOP）和堪萨斯城的儿童慈悲医院（CMH），一个中央实验室（位于罗切斯特大学），以及一个数据协调中心（在约翰·霍普金斯·布卢姆伯格公共卫生学院）成立了一项有期一名的儿童研究，以培养了Chronic of Chronic of Chronic of Chronic of Chronic of Chrorion fecroned。自2003年成立以来，CKID的科学目的是确定肾功能下降的危险因素以及肾功能下降对心血管疾病危险因素的影响；生长失败及其相关的发病率；以及神经认知功能和行为。 The purpose of this application is to request funds to continue the cohort study from August, 2013 to July, 2018. The aims of the current proposal are to assess and improve the accuracy and precision of the CKiD estimating formulas in youth with early CKD, to define the risk of kidney disease progression in children according to the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD according to Cause, GFR and level of albuminuria, to与非斜体诊断和非洲裔美国人相比，定义了肾小球层中GFR加速和非线性下降的危险因素，并评估GFR下降时的身体性能，动脉僵硬和心肌结构以及功能。中西部临床协调中心的首席研究员在儿童肾脏疾病，临床研究设计，招聘和保留率，研究程序的质量控制以及在CKID多个参与地点的协作组织方面具有临床专业知识。 CKID研究涵盖了一项地理和种族多样的队列。 CKID的结构及其对辅助研究的支持继续刺激新的方法，以鉴定肾脏疾病进展的危险因素。 CKID的基础设施继续为初级调查人员和辅助R01的职业发展奖的平台提供，并为更多的高级同事提供。随着更长的随访和对轻度肾功能障碍和肾小球疾病的受试者的额外募集，我们将继续表征与CKD进展及其后遗症有关的新型肾损伤生物标志物，以告知未来的治疗试验。