12/24 Healthy Brain and Child Development National Consortium

12/24 健康大脑和儿童发展国家联盟

• 批准号: 10378922
• 负责人: Alice M Graham
• 金额: $ 101.52万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378922
• 关键词: 10 year old; Address; Adverse event; Affect; Alcohols; Behavioral; Biological; Birth; Brain; COVID-19; Caregivers; Child; Child Development; Communities; Complement; Conceptions; DNA; Data; Data Collection; Data Coordinating Center; Data Set; Development; Enrollment; Environment; Environmental Exposure; Environmental Hazards; Epigenetic Process; Ethics; Event; Exposure to; Feedback; General Population; Genes; Goals; Health; Human; Infant; Infection; Life; Link; Location; Malnutrition; Marijuana; Maternal Health; Measures; Methods; Modality; Monitor; Mothers; Newborn Infant; Opioid; Outcome; Participant; Persons; Physiological; Population; Pregnancy; Pregnant Women; Process; Protocols documentation; Psychopathology; Public Policy; Research; Research Design; Research Personnel; Sampling; Second Pregnancy Trimester; Severities; Shapes; Site; Stress; Structural Racism; Time; Time Study; Tobacco; Toxicant exposure; Training; United States; Woman; Work; base; caregiving; child bearing; cohort; critical period; data harmonization; data integrity; data standards; design; early experience; early life exposure; experience; hazard; high dimensionality; improved; innovation; insight; magnetic resonance imaging/electroencephalography; maltreatment; maternal stress; multimodality; neurodevelopment; neuroimaging; novel; postnatal; pregnant; prenatal; protective factors; psychologic; racial and ethnic; recruit; socioeconomics; sound; substance use; tool

PROJECT SUMMARY/ABSTRACT Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD- NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi- modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state-of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.

项目摘要/摘要 神经发育过程是通过基因和环境之间的动态相互作用来塑造的。 生命早期适应不良的经历会改变发展轨迹，导致有害和持久 发育后遗症。产前和产后危害包括孕产妇的暴露，有毒物质 怀孕和早期生活，孕产妇健康状况，父母心理病理学，虐待， 结构性种族主义和过度压力。阐明各种环境危害如何影响儿童 开发，必须在最初10年的前10年中的发展轨迹模板 生活是根据美国人口中足够大的人口统计学样本来建立的。到 做到这一点，已经形成了健康的大脑和儿童发展国家财团（HBCD-NC） 部署一致，优化和创新的神经影像学（MRI，EEG）的衡量标准 通过大量的行为，生理和心理工具以及生物测量来理解 在24个地点招收的7,500名母亲和婴儿样本中的神经发育轨迹 美国（美国）。 HBCD-NC将在HBCD-指导下执行一个共同的研究方案 NC行政核心（HCAC），将组装和分发一项全面且精心策划的研究 在HBCD-NC数据协调中心的指导下，向科学界的数据集 （HDCC）。 HBCD-NC的总体目标是创建一个全面，统一和高的目标 维度数据集将表征美国儿童中典型的神经发育轨迹 评估生物学和环境暴露如何影响这些轨迹。特别强调 理解产后和产后接触阿片类药物，大麻，酒精，烟草的影响 和/或其他物质。为了解决这些广泛的目标，入学妇女样本将包括：1）a 代表美国人口的种族，种族和社会经济多样性的队列； 2） 孕妇使用靶向物质（阿片类药物，大麻，酒精，烟草）； 3） 人口统计学和行为相似的妇女在怀孕中没有使用物质来实现有效的因果关系 推论。此外，HBCD-NC将确定关键的开发窗口，在此期间有害和 保护环境对后来的神经发育结果具有最大的影响。大型多 本研究将首次生产的模态，纵向和可推广的数据集将提供 使用最先进的方法对儿童发育的新见解。 HBCD-NC研究将通知公众 改善全国儿童健康和发展的政策。