Interparental Conflict And Functional Neural Networks In Infancy

婴儿期的父母间冲突和功能神经网络

基本信息

批准号：
8321249
负责人：
Alice M Graham
金额：
$ 3.55万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-15 至 2013-07-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8321249
关键词：
Adult Affect Age-Months Amygdaloid structure Anterior Apple Area Behavioral Biological Biological Markers Biological Neural Networks Brain Brain region Caregivers Child Childhood Conflict (Psychology)Data Development Disease Early identification Emotional Environmental Risk Factor Exposure to Family Fellowship Functional Magnetic Resonance Imaging Hormonal Individual Infant Investigation Lead Life Link Magnetic Resonance Imaging Measures Medial Mental disorders Methods Neurobiology Neurologic Neuronal Plasticity Outcome Parents Pathway interactions Pattern Peripheral Physiological Play Population Prefrontal Cortex Premature Birth Premature Infant Preventive Intervention Process Program Evaluation Psychopathology Regulation Reliance Research Research Design Research Personnel Rest Risk Risk Factors Role Sampling Scanning School-Age Population Skin Sleep Stress System Techniques Time Training Translational Research Work base biological adaptation to stress biological systems cingulate cortex critical period emotion regulation environmental stressor indexing infancy innovation myelination neurodevelopment neuroimaging relating to nervous system stressor tool

项目摘要

DESCRIPTION (provided by applicant): Interparental conflict is a common early environmental stressor with potential long-term consequences for emotional development and risk for psychopathology. Current research findings suggest that interparental conflict is associated with behavioral and physiological indices of emotion regulation during infancy (Crockenberg, Leerkes, & Lekka, 2007; Moore, 2010). Further, differences in biological systems associated with conflict during infancy have been identified as moderators of risk for school-aged children exposed to conflict (El-Sheikh et al., 2009). However, researchers have not yet explicated how exposure to conflict during infancy may get "under the skin" to affect development of key neural systems. In the proposed study, we will utilize a neuroimaging technique, resting state functional connectivity magnetic resonance imaging, to examine differences in functional neural networks between infants from high and low conflict families. The cortical and limbic (cortico-limbic) level of the biological stress response system and a set of functionally connected regions known to be more activated during rest states, the default network (Raichle et al., 2001), will constitute the focus of this study due to evidence linking the development of these networks both to early adversity and to risk for psychopathology. This work will build on the applicant's ongoing study of two groups of 6- to 12-month- olds screened for high and low interparental conflict. Within this study, fMRI scans are conducted with infants during natural sleep. The purpose of the proposed investigation is to examine whether, among infants from high conflict families, regions of the cortico-limbic network involved in emotional reactivity are less functionally connected to regions important for regulatory processes. We will also investigate whether functional connectivity between regions of the default network previously shown to be less established in preterm infants (Smyser et al., 2010) will be less strong in infants from high conflict families. The current study represents a step towards examining common early environmental stressors in terms of potential consequences for neural networks that have been implicated in mental health disorders. Eventually, such work may facilitate the identification of targets for prevention and intervention and provide a basis for program evaluation in terms of reducing risk at a biological level. The proposed fellowship training covers stress neurobiology in the context of environmental risk, fMRI methods with challenging populations, and rs-fcMRI analyses. Training also focuses on the collaborative process that plays a central role in translational research.

描述（由申请人提供）：互居冲突是一种常见的早期环境压力源，对情绪发展和心理病理的风险有潜在的长期后果。当前的研究发现表明，父母冲突与婴儿期间情绪调节的行为和生理指标有关（Crockenberg，Leerkes和Lekka，2007年； Moore，2010年）。此外，在婴儿期与冲突相关的生物系统上的差异已被确定为暴露于冲突的学龄儿童风险的主持人（Elsheikh等，2009）。但是，研究人员尚未阐明在婴儿期间暴露于冲突可能“在皮肤下”，以影响关键神经系统的发展。在拟议的研究中，我们将利用一种神经成像技术，静止状态的功能连通性磁共振成像，以检查来自高冲突和低冲突家族的婴儿之间功能神经网络的差异。生物应激反应系统的皮质和边缘（皮质 - 膜）水平以及一组在休息状态期间已知已被激活的功能连接的区域，默认网络（Raichle等，2001）将构成这项研究的重点，因为这些网络与早期的逆境和风险相关的群体的发展，这是该研究的重点。这项工作将基于申请人的持续研究，该研究对两组6至12个月的老人进行了筛查，以进行高和低的室内冲突。在这项研究中，fMRI扫描在自然睡眠期间与婴儿进行。拟议的调查的目的是检查在高冲突家族的婴儿中，与情感反应性有关的皮质膜网络的地区是否与对调节过程重要的区域的功能相关。我们还将研究以前显示在早产儿中证明的默认网络区域之间的功能连通性（Smyser等，2010）在高冲突家庭的婴儿中是否会较低。当前的研究是朝着研究与精神疾病有关的神经网络的潜在后果方面迈出的一步。最终，此类工作可能有助于识别预防和干预目标的目标，并就降低生物学水平的风险方面的计划评估提供了基础。拟议的奖学金培训涵盖了在环境风险，具有挑战性人群和RS-FCMRI分析的FMRI方法的背景下进行的压力神经生物学。培训还侧重于在翻译研究中起着核心作用的协作过程。