A targeted approach to examine the influence of maternal psychological stress on newborn brain outcomes

一种有针对性的方法来检查母亲心理压力对新生儿大脑结果的影响

• 批准号: 9789364
• 负责人: Alice M Graham
• 金额: $ 31.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789364
• 关键词: Amygdaloid structure; Anxiety; Area; Biological; Biological Markers; Biology; Birth; Blood specimen; Brain; Characteristics; Chronic; Clinical; Clinical Sciences; Cognitive; Complex; Conceptions; Control Groups; Corticotropin-Releasing Hormone; Cues; Data; Development; Ecological momentary assessment; Economics; Endocrine; Ensure; Environment; Fetus; Foundations; Funding; Human; Hydrocortisone; Immune; Individual; Individual Differences; Infant; Inflammatory; Interleukin-6; Intervention; Intervention Studies; Learning; Link; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mediating; Mediation; Mental Depression; Mental Health; Mental disorders; Mentors; Methodology; Mothers; Natural Disasters; Neuroanatomy; Neurosciences; Newborn Infant; Outcome; Outcomes Research; Pathway interactions; Phase; Prefrontal Cortex; Pregnancy; Pregnant Women; Preventive Intervention; Psychological Stress; Psychopathology; Questionnaires; Randomized Controlled Trials; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Scientist; Specificity; Stress; Structure; System; Techniques; Testing; Training; Woman; Work; base; biological systems; career; cost; cytokine; early life stress; emotion regulation; experience; fetal; intervention effect; longitudinal dataset; maternal stress; mindfulness; mindfulness based cognitive therapy; neural correlate; offspring; postnatal; prenatal; prenatal influence; prenatal stress; prospective test; psychosocial; recruit; skills; sleep quality; social; stem; stress reduction; success; symptomatology; tool; trial design

PROJECT SUMMARY/ABSTRACT Associations between heightened maternal psychological stress during pregnancy and increased risk of offspring psychopathology have been demonstrated repeatedly. Evidence points to the integral role of limbic- prefrontal brain systems (LPFS) in mental health outcomes, and the vulnerability of LPFS to early life stress. Methodological advances allow for examining LPFS in newborn infants, increasing capacity to isolate pre- from postnatal influences. The current proposal builds on this work in several key ways. First, although specific characteristics of psychological stress during pregnancy (e.g. intensity, variability, timing) appear to have important implications for offspring outcomes, research on this topic has yielded inconsistent findings. Second, the framework for understanding associations between maternal psychological stress during pregnancy and offspring brain systems remains correlational. This proposal seeks to increase specificity and advance causal understanding regarding the influence of maternal psychological stress during pregnancy on offspring LPFS. The applicant will examine a unique, existing longitudinal dataset of healthy mother-infant dyads (N=86) with extensive characterization of the prenatal environment and newborn structural and resting state functional connectivity MRI (sMRI and rs-fcMRI). Well suited analytic techniques will be used to identify characteristics of maternal psychological stress during pregnancy (based on 4-days of ecological momentary assessment [EMA] in each trimester) most strongly associated with newborn LPFS (K99, Aim 1). The applicant will then examine EMA measured psychological stress in relation to questionnaire-based stress measures and biological indicators (endocrine and immune/inflammatory) to identify less resource intensive alternative markers (K99, Aim 2). The R00 (Aim 3) will focus on a sample of pregnant women enriched for high levels of psychological stress. It will employ a randomized-controlled-trial of an established stress reduction intervention (Mindfulness- Based Cognitive Therapy=60, Cntrl=60) to test the hypothesis that intervention-induced reduction in maternal psychological stress will influence newborn LPFS. The applicant brings a unique background spanning the fields of DOHaD, developmental neuroscience and clinical science. During the K-phase she will extend her training in intervention research with a focus on intervention with pregnant women to test hypotheses stemming from DOHaD. Training in DOHaD will focus on learning analytic techniques for EMA data, and deepening understanding of maternal stress during pregnancy. Building on her strong foundation in developmental neuroscience, the applicant will gain advanced skills to ensure her success as an independent researcher. The team of mentors, Drs. Fair (developmental neuroscience), Buss (DOHAD), Caughey (clinical science and pregnancy) and McEvoy (preventive intervention during pregnancy), provide expertise in all core areas, span all levels of career stage, and bring an excellent record of obtaining independent funding and mentoring young scientists.

项目摘要/摘要 怀孕期间母亲心理压力的增强与增加的风险之间的关联 后代心理病理学已被反复证明。证据表明边缘的组成部分 心理健康结果中的前额叶脑系统（LPF）以及LPF对早期生活压力的脆弱性。 方法论的进步允许检查新生婴儿的LPF，从 产后影响。当前的提案以多种关键方式建立在这项工作的基础上。首先，尽管具体 怀孕期间心理压力的特征（例如强度，可变性，时机）似乎具有 对后代结果的重要含义，对该主题的研究产生了不一致的发现。第二， 理解怀孕期间母体心理压力与 后代大脑系统仍然相关。该建议旨在提高特异性并提高因果关系 了解孕妇在怀孕期间对后代LPF的影响。 申请人将检查健康母亲二元组的独特的，现有的纵向数据集（n = 86） 随着产前环境以及新生儿结构和静止状态功能的广泛特征 连接MRI（SMRI和RS-FCMRI）。非常适合的分析技术将用于确定 怀孕期间的孕产妇心理压力（基于生态瞬时评估的4天[EMA] 在每个三个月中）与新生儿LPF最密切相关（K99，AIM 1）。然后，申请人将检查 EMA与基于问卷的压力测量和生物学有关的心理压力测量了心理压力 指标（内分泌和免疫/炎症）以识别资源密集型替代标记（K99， 目标2）。 R00（AIM 3）将集中于富含高水平心理的孕妇样本 压力。它将对已建立的减轻压力干预（正念 - 基于认知疗法= 60，cntrl = 60），以检验以下假设：干预引起的母体减少 心理压力将影响新生儿LPF。 申请人带来了独特的背景，涵盖了Dohad的发育神经科学领域 和临床科学。在K期期间，她将扩大干预研究的培训，重点 与孕妇的干预测试来自多哈德的假设。 Dohad的培训将集中在 学习EMA数据的分析技术，并加深对怀孕期间母体压力的了解。 申请人以她在发育神经科学的坚实基础为基础，将获得高级技能 确保她成为独立研究人员的成功。导师团队，博士。公平（发展 神经科学），公共汽车（Dohad），Caughey（临床科学和怀孕）和MCEVOY（预防性 怀孕期间的干预措施），在所有核心领域提供专业知识，跨越各级职业阶段，并带来 获得独立资金和指导年轻科学家的良好记录。