22/24 Healthy Brain and Child Development National Consortium

22/24 健康大脑和儿童发展国家联盟

• 批准号: 10668945
• 负责人: Martha Ann Bell
• 金额: $ 157.34万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-20 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668945
• 关键词: 10 year old; Address; Adverse event; Affect; Alcohols; Behavioral; Biological; Birth; Brain; COVID-19; Caregivers; Child; Child Development; Communities; Complement; Conceptions; DNA; Data; Data Collection; Data Coordinating Center; Data Set; Development; Electroencephalography; Enrollment; Environment; Environmental Exposure; Environmental Hazards; Epigenetic Process; Ethics; Ethnic Origin; Event; Exposure to; Feedback; General Population; Genes; Goals; Health; Helping to End Addiction Long-term; Human; Infant; Infection; Life; Link; Location; Magnetic Resonance Imaging; Malnutrition; Marijuana; Maternal Health; Measures; Methods; Modality; Monitor; Mothers; Newborn Infant; Opiate Addiction; Opioid; Outcome; Participant; Persons; Physiological; Population; Pregnancy; Pregnant Women; Process; Protocols documentation; Psychopathology; Public Health; Public Policy; Race; Research; Research Design; Research Personnel; Sampling; Second Pregnancy Trimester; Severities; Shapes; Site; Speed; Stress; Structural Racism; Supportive care; Time; Time Study; Tobacco; Toxicant exposure; Training; United States; United States National Institutes of Health; Woman; Work; caregiving; child bearing; cohort; critical period; data integrity; data standards; design; early experience; early life exposure; experience; hazard; improved; innovation; insight; maltreatment; maternal stress; multidimensional data; multimodality; neurodevelopment; neuroimaging; novel; opioid misuse; postnatal; pregnant; prenatal; prenatal exposure; protective factors; psychologic; recruit; remote assessment; socioeconomics; sound; substance use; tool

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high-dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant women with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state- of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.

这项研究是NIH的一部分，有助于长期（HEL）倡议结束成瘾，以加快对国家阿片类药物公共卫生危机的科学解决方案。 NIH治疗倡议跨NIH的研究，以改善阿片类药物和成瘾的治疗方法。神经发育过程是通过基因和环境之间的动态相互作用来塑造的。生命早期适应不良的经历会改变发育轨迹，从而导致有害和持久的发育后遗症。产前和产后危害包括物质物质暴露，怀孕和早期生活中的毒性暴露，母子健康状况，父母的心理病理学，虐待，结构性种族主义和过多的压力。为了阐明各种环境危害如何影响儿童的发展，必须在生命的头十年中建立正常的发展轨迹模板 基于美国人口中足够大的人口统计学样本。为此，已经形成了健康的大脑和儿童发展国家财团（HBCD-NC），以部署一系列统一，优化和创新的神经影像学（MRI，EEG）措施，该措施通过大量行为，生理学，心理学和心理学工具以及生物表演来理解，以了解 在美国24个地点（美国）的24个地点，有7,500名母亲和婴儿样本中的神经发育轨迹。 HBCD-NC将在HBCD-NC行政核心（HCAC）的指导下执行一个共同的研究协议，并将在HBCD-NC数据协调中心的指导下，整个科学界组装和分发全面且经过良好的研究数据集 （HDCC）。 HBCD-NC的总体目标是创建一个全面，统一和高维数据集，该数据集将表征美国儿童中典型的神经发育轨迹，并评估生物学和环境暴露如何影响这些轨迹。将放置特别的重点 了解产前和产后接触阿片类药物，大麻，酒精，烟草和/或其他物质的影响。为了解决这些广泛的物体，入学的妇女样本将包括：1）代表美国人口的大致，种族和社会经济多样性的同类群体； 2）孕妇 使用靶向物质（阿片类药物，大麻，酒精，烟草）； 3）在人口统计学和行为上相似的妇女在怀孕中没有使用物质，以实现有效的因果推论。此外，HBCD-NC将确定有害环境和受保护环境最多的关键发展窗口 对后来神经发育结果的影响。这项研究将首次生产的大型，多模式，纵向和可推广的数据集将使用最先进的方法为儿童发育提供新的见解。 HBCD-NC研究将为公共政策提供指导，以改善全国儿童的健康和发展。