Precursors of Anxiety: The Role of Lateralized Brain Activation and Maternal Sensitivity

焦虑的前兆：侧脑激活和母亲敏感性的作用

• 批准号: 10362971
• 负责人: Martha Ann Bell
• 金额: $ 75.33万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10362971
• 关键词: Address; Adult; Age-Months; Amygdaloid structure; Anxiety; Anxiety Disorders; Apgar Score; Attenuated; Automobile Driving; Behavior; Behavioral; Behavioral Model; Behavioral inhibition; Birth; Brain; Buffers; Caregivers; Child; Childhood; Communities; Complex; Coupled; Coupling; Data Collection; Demographic Factors; Development; Disease; Electroencephalogram; Electrophysiology (science); Enrollment; Etiology; Evaluation; Family; Foundations; Fright; Functional Magnetic Resonance Imaging; Gestational Age; Growth; Individual Differences; Infant; Interview; Jupiter; Laboratories; Left; Life; Link; Location; Longevity; Measures; Medical; Methods; Modeling; Mothers; Negative Valence; Parents; Pattern; Play; Preventive; Psychopathology; Psychophysiology; Questionnaires; Reporting; Research; Research Domain Criteria; Resources; Risk; Role; Sampling; Services; Shapes; Site; Structure; Symptoms; Temperament; Testing; Time; Training; Translating; Tweens; Universities; Weight; anxiety symptoms; anxious behavior; behavior observation; computerized data processing; cost; design; ethnic diversity; infancy; longitudinal design; maternal depression; neurophysiology; racial and ethnic; recruit; socioeconomics; therapeutic target; transmission process

Anxiety disorders represent the most prevalent type of psychopathology across the lifespan. Fear/avoidance, temperament precursors of anxiety symptoms, can be observed reliably in the first year of life. Thus, develop- ment of fear, a critical component of the Research Domain Criteria (RDoC) negative valence constellation, is important in its own right, and represents an early marker of anxiety symptoms. Fearful temperament has been linked with a distinct neurophysiological signature – relative right frontal activation, detectable via electroen- cephalogram (EEG) recording. Dynamic reciprocal effects between the left and right hemispheres contribute to this asymmetry as well as associated behavioral states of fear/avoidance, and shape risk versus protection with respect to anxiety. Maternal sensitivity not only effects fear development, but also moderates links be- tween fear reactivity and anxiety symptoms. The present study addresses an important gap in research, exam- ining reciprocal effects between changes in left and right frontal activation as a vehicle for transmission of anxi- ety-related risk, along with fearful reactivity, considering maternal sensitivity as a moderator. It is hypothe- sized that (1) dominance of right hemisphere change effects on left activation growth across infancy and coupling of accelerated changes in infant fearfulness and shifts in the associated electrophysio- logical signature will confer the risk for anxiety; (2) early maternal sensitivity will serve to attenuate links between psychophysiological risk and anxiety, accentuating it later. The following specific aims are proposed: Aim 1. Infant fearfulness: Modeling behavioral and EEG changes moderated by maternal sensitivity. We will enroll mothers with infants (n=300) at three sites: Pullman, WA, Blacksburg, VA, and Jupiter, FL, re- quired to provide racial/ethnic diversity in the overall sample recruited from otherwise demographically similar communities, and because of data collection/processing demands associated with the longitudinal design. We will conduct multi-method bimonthly assessments of infant fear from 6 to 18 months, relying on a planned missingness design. Infant EEG will be recorded to measure frontal activation along with observations of ma- ternal sensitivity. Dynamic latent change effects will be modeled for behavioral and EEG indicators, providing a picture of development across infancy and setting the stage for Aim 2. Explaining anxiety onset: Contributions of latent change in fear, electrophysiology, and sensitivity. Contributions of changes in fear and related electro- physiology to the emergence of anxiety will be quantified, considering moderation of maternal sensitivity. Chil- dren will be followed until 24 months of age, obtaining questionnaire and structured interview parent-report, as well as observations of behavioral inhibition/anxious behaviors. Latent change scores for fear and frontal EEG power on the left and the right will be modeled as predictors of anxiety, with maternal sensitivity as a moderator of these links. Completion of the proposed evaluation is expected to clarify the role of fear development and maternal sensitivity in the onset of anxiety symptoms, informing preventative efforts (e.g., parent training).

焦虑症代表了整个生命周期中最普遍的心理病理学类型。恐惧/避免， 可以在生命的第一年可靠地观察到焦虑症状的气质前体。那，发展 - 恐惧是研究领域标准（RDOC）负价星座的关键组成部分，是 本身重要，代表了焦虑症状的早期标志。可怕的温度已经 与独特的神经生理学特征相关 - 相对右额激活，可通过电气检测到 头膜记录（EEG）记录。左半球和右半球之间的动态相互影响有助于 这种不对称和相关的恐惧/避免行为状态，形状风险与保护 关于动画。孕产妇的敏感性不仅会影响恐惧发展，而且还调节了联系。 补间害怕反应性和焦虑症状。本研究解决了研究，考试的重要差距 左侧和右额激活中的变化之间的相互影响是作为焦虑传播的载体 考虑到遗传敏感性作为主持人，与ETY相关的风险以及可怕的反应性。这是假设的 （1）右半球变化对婴儿左激活生长的影响 以及婴儿恐惧性的加速变化和相关电物体的转移的加速变化 逻辑签名将赋予焦虑的风险； （2）早期母体敏感性将有助于减弱 心理生理风险与焦虑之间的联系，以后会突出。以下具体目的是 提出的：目标1。婴儿的恐惧：对行为和脑电图的建模变化，孕产妇的敏感性调节。 我们将在三个地点注册有婴儿的母亲（n = 300）：铂尔曼，华盛顿州，布莱克斯堡，弗吉尼亚州和木星，佛罗里达州 要求从其他人口统计学相似的总体样本中提供种族/种族多样性 社区，以及由于数据收集/处理的要求，与纵向设计相关。我们 依靠计划的 缺失设计。将记录婴儿脑电图以测量额叶激活以及观察 动态潜在变化效果将为行为和脑电图指标建模，提供一个 跨婴儿期发展的图片并为目标奠定了舞台2。解释动画发作：贡献 恐惧，电生理学和灵敏度的潜在变化。恐惧和相关电的变化的贡献 考虑到孕产妇敏感性的适度，将量化焦虑出现的生理学。 ch Dren将遵循直到24个月大，获得问卷调查和结构化的面试父母报告， 以及对行为抑制/焦虑行为的观察。恐惧和额叶脑电图的潜在变化得分 左侧和右侧的功率将被建模为焦虑的预测指标，而母体敏感性作为主持人 这些链接。预计拟议评估的完成将阐明恐惧发展的作用和 母体敏感性在焦虑症状发作中，为预防性努力（例如，父母培训）提供了信息。