Dissecting the impact of forced displacement on Type Two Diabetes

剖析强迫流离失所对二型糖尿病的影响

• 批准号: 9791038
• 负责人: Lu Qi
• 金额: $ 15.31万
• 依托单位: LEBANESE AMERICAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791038
• 关键词: Address; Adopted; Adult; Adverse effects; Affect; Age; American; Biometry; Chronic; Clinical; Clinical Psychology; Cohort Studies; Collaborations; Communicable Diseases; Complex; Conflict (Psychology); Country; Data; Dehydration; Development; Diabetes Mellitus; Diagnostic; Diet; Diet Habits; Disease; Ensure; Epidemiology; Genomics; Goals; Health; Health Sciences; Health system; High Prevalence; Individual; Inflammation; Insulin Resistance; Interdisciplinary Study; International; Lead; Lebanon; Life; Life Style; Link; Longitudinal cohort; Medical; Metabolic; Metabolic Diseases; Middle East; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Patients; Persons; Phenotype; Pilot Projects; Population; Population Genetics; Prediabetes syndrome; Prevention strategy; Primary Health Care; Prospective cohort; Public Health; Qi; Refugees; Research; Research Infrastructure; Research Personnel; Starvation; Stress; Syria; Testing; Universities; Variant; Violence; War; Woman; acute stress; analytical tool; care providers; cohort; diabetes risk; disorder risk; electronic registry; health care availability; high risk; holistic approach; improved; knowledge base; loved ones; low and middle-income countries; men; mortality; multidisciplinary; natural hypothermia; obesity prevention; patient population; patient registry; population health; programs; prospective; psychosocial; recruit; research study; social exclusion; stressor; treatment strategy; violence exposure

Abstract Currently, Lebanon has the highest per capita concentration of refugees in the world, where one in four persons in Lebanon is displaced from Syria. While several studies have focused on the occurrence of communicable diseases among refugees, data are extremely limited about the effects of forced displacement on chronic, noncommunicable diseases (NCDs) such as type 2 diabetes (T2D). We hypothesize that forced displacement leading to adverse changes in lifestyle is associated with T2D and other NCDs development. Our objective is to plan for the establishment of a sustainable collaborative research platform by building a unique prospective longitudinal cohort of individuals belonging to refugee and host population, providing opportunities to conduct a multitude of multidisciplinary studies investigating the short and long-term health effects of forced displacement on T2D. Accordingly the proposed project is not only relevant to an urgent and growing Low and Middle Income Countries (LMIC) priority, but will improve the capacity in the LMIC to conduct such research studies. We plan to achieve our objective by: 1) providing a detailed plan for establishing a prospective cohort that will include approximately 8,000 men and women with a wide age range, who will be recruited from a selected subset (n=70) of Primary Health Care Centers (PHCs) serving 49,023 patients including 7,733 Syrian refugees and 2) conducting a pilot study assessing the impact of forced displacement and adverse lifestyle changes on T2D development in a subset of refugee and host population patients. The proposed project would provide an ideal setting to apply analytic tools grounded with a life-stage, holistic approach and a multidisciplinary strategy that integrates epidemiology and population health sciences to advance our understanding of the determinants of T2D and other NCDs. The proposed project will prepare the research infrastructure (data, networking, capacity building) required for more comprehensive research programs that enhance the knowledge base and add to the long-term goals of sustainably strengthening research capacity in LMICs to address NCDs. Accordingly, it will result in better diagnostics, prevention, and treatment strategies.

抽象的 目前，黎巴嫩的人均难民集中最高 黎巴嫩四分之一的人从叙利亚流离失所。而几项研究则集中 关于难民之间传染病的发生，数据极为有限 关于强制位移对慢性，非传染性疾病（NCD）的影响 作为2型糖尿病（T2D）。我们假设强迫位移导致不利 生活方式的变化与T2D和其他NCDS开发有关。我们的目标是 通过建立独特的独特的计划来建立可持续协作研究平台 属于难民和寄宿人口的个人的前瞻性纵向队列， 提供机会进行大量的多学科研究，以调查 强迫位移对T2D的短期和长期健康影响。因此提议 项目不仅与紧急和增长的低收入和中等收入国家（LMIC）有关 优先级，但将提高LMIC进行此类研究的能力。 我们计划通过以下方式实现我们的目标：1）提供详细的计划来建立潜在的 队列将包括大约8,000名年龄范围较高的男人和女人，他们将 可以从选定的初级卫生保健中心（PHC）的子集（n = 70）招募 为49,023名患者提供服务，包括7,733名叙利亚难民和2）进行试点研究 评估强制流离失所和不利生活方式对T2D的影响 在难民和宿主人群患者的一部分中发展。拟议的项目将 提供理想的设置，以应用以生命阶段，整体方法为基础的分析工具 以及整合流行病学和人口健康科学的多学科策略 促进我们对T2D和其他NCD的决定因素的理解。 拟议的项目将准备研究基础架构（数据，网络，容量 建筑物）更全面的研究计划需要增强知识 基础并增加了可持续增强LMIC研究能力的长期目标 解决NCD。因此，这将导致更好的诊断，预防和治疗 策略。