Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota

减肥饮食对肠道菌群心脏代谢因素的干预

• 批准号: 10311104
• 负责人: Lu Qi
• 金额: $ 62.02万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311104
• 关键词: Address; Adipose tissue; Affect; Basal metabolic rate; Biochemical; Blood; Blood Circulation; Blood Pressure; Blood specimen; Body Weight Changes; Body Weight decreased; Cardiometabolic Disease; Ceramides; Citric Acid Cycle; Clinical; Collection; Communication; Data; Development; Diet; Diet Modification; Dietary Factors; Dietary Intervention; Dietary intake; Dual-Energy X-Ray Absorptiometry; Eicosanoids; Fatty acid glycerol esters; Glucose; Goals; Health; Heart; Hormones; Human; Inflammation; Intervention; Kidney; Knowledge; Lead; Lecithin; Lipids; Liver; Longitudinal Studies; Macronutrients Nutrition; Magnetic Resonance Imaging; Measures; Mediating; Metabolic; Metabolism; MicroRNAs; Muscle; Obesity; Organ; Pancreas; Phosphatidylethanolamine; Plasma; Play; Prevention strategy; Research; Resources; Role; Scanning; Skeletal Muscle; Sphingomyelins; System; Systems Analysis; Tissues; Transducers; Triglycerides; Volatile Fatty Acids; X-Ray Computed Tomography; adipokines; cardiometabolic risk; cardiometabolism; circulating microRNA; dietary; doubly-labeled water; energy balance; gut microbiota; host microbiota; improved; innovation; insulin sensitivity; metabolomics; microbial; microbiota; novel; obesity development; obesity management; obesity prevention; obesity risk; proctolin; prospective; response; secondary analysis; sensor; total energy expenditure; treatment strategy; weight loss intervention

Abstract Compelling evidence has implicated human gut microbiota in development of obesity and related cardiometabolic disorders. Recent studies identified a group of circulating metabolites that are functionally related to gut microbiota. These microbial metabolites act as ‘transducers’ in the microbiota-host communications and ‘sensors’ in gut-organ/tissue crosstalk, and affect ectopic fat distribution in various metabolic organs and tissues. Diet is among the most important regulators of gut microbiota; however, no study has assessed how weight-loss diets may affect the long-term changes of the newly identified microbial metabolites. The proposed systems study aims to fill this significant research gap. In two of the longest and largest comparator trials on the popular weight-loss diets - POUNDS LOST and CENTRAL, we propose to identify novel plasma microbial metabolites associated with long-term weight loss in response to diet interventions. We will examine relations of plasma levels of identified microbial metabolites and ectopic fat distribution in the liver, heart, pancreas, and kidney, as well as adipose and skeletal muscle tissues. In addition, we will assess whether changes in plasma microbial metabolites mediate the relations between weight loss and changes in cardiometabolic markers. Moreover, we will examine the dynamic associations between microbial metabolites and changes in plasma miRNAs related to obesity and cardiometabolic risk. The findings from our study will considerably improve development of novel prevention and treatment strategies for obesity and related cardiometabolic disorders.

抽象的 令人信服的证据已在肥胖和相关的发展中实施了人类肠道菌群 心脏代谢疾病。最近的研究确定了一组功能上的循环代谢产物 与肠道微生物群有关。这些微生物代谢产物在微生物群中充当“传感器” 肠道/组织串扰中的通信和“传感器”，并影响各种生态脂肪分布 代谢器官和组织。饮食是肠道菌群最重要的调节剂之一。但是，不 研究评估了减肥饮食如何影响新鉴定的微生物的长期变化 代谢物。拟议的系统研究旨在填补这一重大的研究空白。在最长的两个中 关于流行减肥饮食的最大比较器试验 - 损失和中心，我们建议 确定与饮食相关的长期体重减轻相关的新型血浆微生物代谢产物 干预措施。我们将检查已鉴定的微生物代谢产物和异位脂肪的血浆水平的关系 肝脏，心脏，胰腺和肾脏以及脂肪和骨骼肌组织中的分布。此外， 我们将评估血浆微生物代谢物的变化是否介导了体重减轻之间的关系 和心脏代谢标记的变化。此外，我们将研究之间的动态关联 微生物代谢物以及与肥胖和心脏代谢风险有关的血浆miRNA的变化。发现 从我们的研究中，将考虑改善肥胖症的新型预防和治疗策略的发展 和相关的心脏代谢性疾病。

项目成果

Maternal GDM Status, Genetically Determined Blood Glucose, and Offspring Obesity Risk: An Observational Study.

• DOI: 10.1002/oby.23047
• 发表时间: 2021-01
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Song Q;Wang L;Liu H;Liang Z;Chen Y;Sun D;Li W;Leng J;Yang X;Cardoso MA;Hu G;Qi L
• 通讯作者: Qi L

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

• DOI: 10.1136/bmj.i4707
• 发表时间: 2016-09-20
• 期刊: BMJ (Clinical research ed.)
• 作者: Livingstone KM;Celis-Morales C;Papandonatos GD;Erar B;Florez JC;Jablonski KA;Razquin C;Marti A;Heianza Y;Huang T;Sacks FM;Svendstrup M;Sui X;Church TS;Jääskeläinen T;Lindström J;Tuomilehto J;Uusitupa M;Rankinen T;Saris WH;Hansen T;Pedersen O;Astrup A;Sørensen TI;Qi L;Bray GA;Martinez-Gonzalez MA;Martinez JA;Franks PW;McCaffery JM;Lara J;Mathers JC
• 通讯作者: Mathers JC

Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial.

• DOI: 10.1038/ijo.2017.28
• 发表时间: 2017-06
• 期刊: International journal of obesity (2005)
• 作者: Liu G;Liang L;Bray GA;Qi L;Hu FB;Rood J;Sacks FM;Sun Q
• 通讯作者: Sun Q

Dietary Protein Modifies the Effect of the MC4R Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial.

膳食蛋白质改变 MC4R 基因型对食欲和食物渴望 2 年变化的影响：POUNDS Lost 试验。

• DOI: 10.3945/jn.116.242958
• 发表时间: 2017
• 期刊: The Journal of nutrition
• 作者: Huang,Tao;Zheng,Yan;Hruby,Adela;Williamson,DonaldA;Bray,GeorgeA;Shen,Yiru;Sacks,FrankM;Qi,Lu
• 通讯作者: Qi,Lu