Improved Whole-Brain Spectroscopic MRI for Radiation Treatment Planning

改进的全脑光谱 MRI 用于放射治疗计划

基本信息

批准号：
9791190
负责人：
Lee Cooper
金额：
$ 78.44万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-22 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9791190
关键词：
Achievement Adjuvant Adopted Adoption Algorithms Area Brain Brain Neoplasms Brain imaging Cells Cerebrum Choline Clinical Clinical Management Clinical Research Collaborations Computer software Data Data Set Decision Making Deltastab Detection Development Disease Dose Engineering Enhancing Lesion Enrollment Excision Frequencies Future Genomics Glioblastoma Glioma Goals Head Image Infiltration Institution Knowledge Lead Left Lipids Magnetic Resonance Imaging Malignant neoplasm of brain Maps Methods Morbidity - disease rate Motion Multi-Institutional Clinical Trial N-acetylaspartate Nature Newly Diagnosed Outcome Patients Pattern Performance Protocols documentation Radiation Radiation Dose Unit Radiation therapy Recurrence Reproducibility Research Resolution Signal Transduction Site Software Tools Technology Testing Time Tissues Tumor Volume Update Visualization software base brain volume central database chemotherapy clinical imaging cloud based data management data visualization design effective therapy high risk imaging modality improved magnetic field mortality reconstruction software systems spectroscopic imaging standard of care subcutaneous success temozolomide tool treatment planning tumor web based interface

项目摘要

Identifying the extent of glioma tumor margins for radiation treatment planning remains a challenging task due to the infiltrative nature of these tumors and limitations in current standard imaging methods. Multiple studies including our own have demonstrated that MR spectroscopic imaging, or spectroscopic MRI (sMRI), can detect areas of infiltrating tumor with a high degree of sensitivity, and could be an essential tool in treating areas that lead to early recurrence. sMRI enables the identification of infiltrating cells that are marked by increased Choline/N-Acetylaspartate ratios, including regions that are not detectable by standard MRI and normally left untreated. Therefore, sMRI shows considerable promise for improving the efficacy of radiation treatment and significantly delay recurrence. However, technological improvements are needed before sMRI can be broadly adopted for clinical use. This study will achieve this goal by leveraging diverse areas of expertise at four research sites to engineer and validate technological improvements needed to improve sMRI acquisition, analysis, and clinical integration. These improvements will include new magnet shimming technology to increase the spatial coverage of sMRI to whole-brain volumes; updated rapid and motion-robust sMRI method that incorporates compressed sensing to both increase spatial resolution and decrease acquisition times; and new processing, display, and analysis methods that will present metabolite maps in an efficient manner with a clinician-friendly web-based interface that enables integration with radiation treatment planning software systems. The value and efficacy of the technological developments will be validated in a clinical study at the participating sites that will incorporate sMRI into RT planning for glioblastoma, using an escalated dose for regions of significantly increased Cho/NAA. The completion of this study will provide robust sMRI acquisition methods and software tools that will be suitable for clinical use.

确定放射治疗计划的神经胶质瘤肿瘤边缘范围仍然是一项具有挑战性的任务，因为这些肿瘤的浸润性质和当前标准成像方法的局限性。多项研究包括我们自己的研究已经证明，MR 光谱成像或光谱 MRI (sMRI) 可以检测具有高度敏感性的浸润性肿瘤区域，并且可能是治疗以下区域的重要工具导致早期复发。 sMRI 能够识别以增加的浸润细胞为标志的浸润细胞。胆碱/N-乙酰天冬氨酸比率，包括标准 MRI 无法检测到且通常留下的区域未经治疗。因此，sMRI 在提高放射治疗的疗效和治疗效果方面显示出巨大的前景。明显延缓复发。然而，在 sMRI 广泛应用之前，还需要技术改进被采纳用于临床。本研究将通过利用四个领域的不同专业知识来实现这一目标研究场所设计和验证改善 sMRI 采集所需的技术改进，分析和临床整合。这些改进将包括新的磁体匀场技术增加 sMRI 对全脑体积的空间覆盖范围；更新的快速且运动稳健的 sMRI 方法结合压缩传感来提高空间分辨率并减少采集时间；和新的处理、显示和分析方法，将以有效的方式呈现代谢图谱临床医生友好的网络界面，可与放射治疗计划软件集成系统。技术发展的价值和功效将在临床研究中得到验证参与站点将 sMRI 纳入胶质母细胞瘤 RT 计划中，使用递增剂量 Cho/NAA 显着增加的区域。这项研究的完成将提供强大的 sMRI 采集适合临床使用的方法和软件工具。