Improved Whole-Brain Spectroscopic MRI for Radiation Treatment Planning

改进的全脑光谱 MRI 用于放射治疗计划

• 批准号: 9791190
• 负责人: Lee Cooper
• 金额: $ 78.44万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-22 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791190
• 关键词: Achievement; Adjuvant; Adopted; Adoption; Algorithms; Area; Brain; Brain Neoplasms; Brain imaging; Cells; Cerebrum; Choline; Clinical; Clinical Management; Clinical Research; Collaborations; Computer software; Data; Data Set; Decision Making; Deltastab; Detection; Development; Disease; Dose; Engineering; Enhancing Lesion; Enrollment; Excision; Frequencies; Future; Genomics; Glioblastoma; Glioma; Goals; Head; Image; Infiltration; Institution; Knowledge; Lead; Left; Lipids; Magnetic Resonance Imaging; Malignant neoplasm of brain; Maps; Methods; Morbidity - disease rate; Motion; Multi-Institutional Clinical Trial; N-acetylaspartate; Nature; Newly Diagnosed; Outcome; Patients; Pattern; Performance; Protocols documentation; Radiation; Radiation Dose Unit; Radiation therapy; Recurrence; Reproducibility; Research; Resolution; Signal Transduction; Site; Software Tools; Technology; Testing; Time; Tissues; Tumor Volume; Update; Visualization software; base; brain volume; central database; chemotherapy; clinical imaging; cloud based; data management; data visualization; design; effective therapy; high risk; imaging modality; improved; magnetic field; mortality; reconstruction; software systems; spectroscopic imaging; standard of care; subcutaneous; success; temozolomide; tool; treatment planning; tumor; web based interface

Identifying the extent of glioma tumor margins for radiation treatment planning remains a challenging task due to the infiltrative nature of these tumors and limitations in current standard imaging methods. Multiple studies including our own have demonstrated that MR spectroscopic imaging, or spectroscopic MRI (sMRI), can detect areas of infiltrating tumor with a high degree of sensitivity, and could be an essential tool in treating areas that lead to early recurrence. sMRI enables the identification of infiltrating cells that are marked by increased Choline/N-Acetylaspartate ratios, including regions that are not detectable by standard MRI and normally left untreated. Therefore, sMRI shows considerable promise for improving the efficacy of radiation treatment and significantly delay recurrence. However, technological improvements are needed before sMRI can be broadly adopted for clinical use. This study will achieve this goal by leveraging diverse areas of expertise at four research sites to engineer and validate technological improvements needed to improve sMRI acquisition, analysis, and clinical integration. These improvements will include new magnet shimming technology to increase the spatial coverage of sMRI to whole-brain volumes; updated rapid and motion-robust sMRI method that incorporates compressed sensing to both increase spatial resolution and decrease acquisition times; and new processing, display, and analysis methods that will present metabolite maps in an efficient manner with a clinician-friendly web-based interface that enables integration with radiation treatment planning software systems. The value and efficacy of the technological developments will be validated in a clinical study at the participating sites that will incorporate sMRI into RT planning for glioblastoma, using an escalated dose for regions of significantly increased Cho/NAA. The completion of this study will provide robust sMRI acquisition methods and software tools that will be suitable for clinical use.

确定辐射治疗计划的神经胶质瘤肿瘤边缘的程度仍然是一项具有挑战性的任务 这些肿瘤的渗透性和当前标准成像方法中的局限性。多个研究 包括我们自己的包括MR光谱成像或光谱MRI（SMRI）可以检测到 具有高度敏感性的浸润肿瘤区域，并且可能是治疗区域的重要工具 导致早期复发。 SMRI实现了以增加的标志性浸润细胞的鉴定 胆碱/N-乙酰天冬氨酸比率，包括标准MRI无法检测到的区域，通常为左 未经处理。因此，SMRI表现出可提高辐射处理功效和 明显延迟复发。但是，在SMRI可以广泛地进行之前，需要进行技术改进 用于临床用途。这项研究将通过利用四个专业知识领域来实现这一目标 研究站点以改善SMRI获取所需的工程和验证技术改进， 分析和临床整合。这些改进将包括新的磁铁机构技术 将SMRI的空间覆盖范围增加到全脑量；更新快速，运动稳定的SMRI方法 这将压缩感纳入了增加空间分辨率和减少的获取时间。和 新的处理，显示和分析方法将以有效的方式呈现代谢物图 基于临床医生友好的基于网络的界面，可以与辐射处理计划软件集成 系统。技术发展的价值和功效将在临床研究中得到验证 参与的网站将使用SMRI纳入胶质母细胞瘤的RT计划，并使用升级剂量 CHO/NAA的区域显着增加。这项研究的完成将提供强大的SMRI收购 适合临床使用的方法和软件工具。