Staying Strong and Healthy during Androgen Deprivation Therapy for Latino Men

拉丁裔男性在雄激素剥夺疗法期间保持强壮和健康

基本信息

批准号：
8650129
负责人：
SALLY L Maliski
金额：
$ 64.95万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8650129
关键词：
Accounting Achievement Address Adjuvant Adopted Adoption Adverse effects American Androgens Attention Awareness Behavior Blood Glucose Body mass index Bone Density Cardiovascular Diseases Cardiovascular system Cause of Death Center for Translational Science Activities Cessation of life Cholesterol Congestive Heart Failure Cutaneous Data Diabetes Mellitus Diagnosis Disease Dyslipidemias Eating Education Emotional Ethnic Origin Event Exercise Fatigue Fatty acid glycerol esters Food Glucose Goals Health Height High Density Lipoproteins Hip region structure Hispanics Hot flushes Hypertension Individual Intervention Interview Latino Lipids Los Angeles Low-Density Lipoproteins Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Depression Metabolic Metabolic syndrome Methods Minority Modeling Monitor Morbidity - disease rate Myocardial Infarction Neoadjuvant Therapy Non-Insulin-Dependent Diabetes Mellitus Nurses Obesity Operative Surgical Procedures Osteoporosis Outcome Outcome Measure Participant Patients Perception Personal Communication Personal Satisfaction Physiological Prevention program Process Prostate Cancer Outcomes Study Prostate Cancer therapy Quality of life Radiation Radiation therapy Randomized Recruitment Activity Recurrence Relative (related person)Risk SF-12 Serum Sexual Dysfunction Site Stage at Diagnosis Staging Subgroup Techniques Telephone Testing Time Triglycerides United States Vasomotor Visceral Waist-Hip Ratio Weight Wife cancer diagnosis cardiovascular disorder risk comparison group depressive symptoms deprivation design diabetes risk fitness good diet group intervention health related quality of life high risk improved indexing interest men muscle form nutrition post intervention programs public health relevance theories treatment as usual

项目摘要

Androgen deprivation therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage. This becomes highly significant considering that prostate cancer is the most commonly diagnosed noncutaneous cancer in American men. Of particular concern are Latino men, because Latinos are the fastest growing minority in the United States (US). Latino men are diagnosed with later stage disease making them more likely to be treated with ADT. Studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health- related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, metabolic syndrome, increased fat mass, along with decreased lean muscle mass, increased serum lipids, and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes. Latinos more often have obesity, dyslipidemia, low cardiovascular fitness, hypertension, and diabetes. Therefore, we propose to test our Staying Strong and Healthy program to promote healthy activity and nutrition during ADT for Latino men. Using a mixed methods design we aim to: 1. Compare pre- and post-intervention BMI, lipids, waist/hip circumference, and glucose within and between 75 Latino men starting ADT who are randomly assigned to receive the Staying Strong and Healthy intervention and 75 Latino men starting ADT randomly assigned to receive usual care. 2. Compare pre- and post- intervention HRQOL using the SF-12 subscales of emotional and physical well-being and disease-specific HRQOL using the Expanded Prostate Cancer Index Composite (EPIC) within and between groups. 3. Develop and compare explanatory models of Latino men's activity and nutrition choices between those receiving the intervention and those receiving usual care. 4. Evaluate acceptability and benefit of the intervention from perspective of participants. Latino men will be recruited form several sites serving predominantly Latino populations in Los Angeles. Men will come to UCLA Center for Translational Research for baseline, 6 and 12 months measures and interview at 12 months. Men assigned to the intervention group will receive initial assessment and education on nutrition and the exercised program immediately following baseline measures. They will then receive 12 weekly calls from a nurse coordinator/cultural liaison team to deliver focused information, establish individually tailored nutrition and activity goals, assess accomplishments of goals and provide support. We will conduct qualitative interview with 30 men from each group to assess the intervention from their perspective and to develop explanatory frameworks for decision process used relative to food and activity choices. Analysis will combine within and between group comparisons and grounded theory techniques.

雄激素剥夺疗法（ADT）越来越多地用于治疗新辅助治疗前列腺癌和放射治疗（RT）的辅助背景，用于手术或手术或辐射，或者前列腺癌处于晚期阶段。考虑到这变得非常重要这种前列腺癌是美国男性最常见的非皮肤癌。特别关注的是拉丁裔男人，因为拉丁美洲人是美国增长最快的少数群体（美国）。拉丁裔男性被诊断出患有后期疾病，使他们更有可能接受ADT治疗。研究有表明，ADT上的男性患血管舒适症状，抑郁，疲劳，健康状况的风险增加了 - 相关生活质量（HRQOL），骨矿物质密度降低（BMD），性功能障碍，代谢综合征，脂肪质量增加，以及瘦肌肉质量降低，血清脂质增加和降低动脉依从性，所有这些使他们面临更高的心血管疾病风险（CVD），骨质疏松症和II型糖尿病。拉丁美洲人经常患有肥胖症，血脂异常，心血管健身低，高血压和糖尿病。因此，我们建议测试我们保持强大健康的计划在拉丁美洲人的ADT期间，促进健康的活动和营养。使用混合方法设计我们的目标是：1。比较干预前和干预后BMI，脂质，腰围/臀部周长和葡萄糖在75 拉丁美洲人开始随机分配ADT，以接受坚强健康的干预措施和75名开始随机分配ADT的拉丁裔男子接受常规护理。 2。比较前后干预HRQOL使用情绪和身体健康和特定疾病的SF-12分量表 HRQOL使用组之间和之间的前列腺癌指数复合材料（EPIC）。 3。发展并比较接受拉丁裔男性活动和营养选择的解释模型干预和接受常规护理的人。 4。评估干预的可接受性和利益参与者的观点。拉丁美洲人将被招募，形式为主要是拉丁裔的几个网站洛杉矶的人口。男子将来到加州大学洛杉矶分校的基线转化研究中心，6和12 在12个月时进行了几个月的措施和面试。分配给干预小组的男人将获得初始基线措施后，对营养和行使计划的评估和教育。然后，他们将收到护士协调员/文化联络小组的每周12个电话，以提供专注信息，建立单独量身定制的营养和活动目标，评估目标的成就和提供支持。我们将对来自每个小组的30名男子进行定性访谈以评估干预措施从他们的角度来看，并开发相对于食物的决策过程的解释性框架活动选择。分析将在小组比较和接地理论之间结合技术。