Staying Strong and Healthy during Androgen Deprivation Therapy for Latino Men

拉丁裔男性在雄激素剥夺疗法期间保持强壮和健康

基本信息

批准号：
8931060
负责人：
SALLY L Maliski
金额：
$ 61.98万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2016-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8931060
关键词：
Accounting Achievement Address Adjuvant Adopted Adoption Adverse effects American Androgens Attention Awareness Behavior Blood Glucose Body mass index Bone Density Cardiovascular Diseases Cardiovascular system Cause of Death Center for Translational Science Activities Cessation of life Cholesterol Congestive Heart Failure Cutaneous Data Diabetes Mellitus Diagnosis Disease Dyslipidemias Eating Education Emotional Ethnic Origin Event Exercise Fatigue Fatty acid glycerol esters Food Glucose Goals Health Height High Density Lipoproteins Hip region structure Hispanics Hot flushes Hypertension Individual Intervention Interview Latino Lipids Los Angeles Low-Density Lipoproteins Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Depression Metabolic Metabolic syndrome Methods Minority Modeling Monitor Morbidity - disease rate Myocardial Infarction Neoadjuvant Therapy Non-Insulin-Dependent Diabetes Mellitus Nurses Obesity Operative Surgical Procedures Osteoporosis Outcome Outcome Measure Participant Patients Perception Personal Communication Personal Satisfaction Physiological Prevention program Process Prostate Cancer Outcomes Study Prostate Cancer therapy Quality of life Radiation Radiation therapy Randomized Recruitment Activity Recurrence Relative (related person)Risk SF-12 Serum Sexual Dysfunction Site Stage at Diagnosis Staging Subgroup Techniques Telephone Testing Time Triglycerides United States Vasomotor Visceral Waist-Hip Ratio Weight Wife cancer diagnosis cardiovascular disorder risk comparison group depressive symptoms deprivation design diabetes risk fitness good diet group intervention health related quality of life high risk improved indexing interest men muscle form nutrition post intervention programs theories treatment as usual

项目摘要

DESCRIPTION (provided by applicant): Androgen deprivation therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage. This becomes highly significant considering that prostate cancer is the most commonly diagnosed no cutaneous cancer in American men. Of particular concern are Latino men, because Latinos are the fastest growing minority in the United States (US). Latino men are diagnosed with later stage disease making them more likely to be treated with ADT. Studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health- related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, metabolic syndrome, increased fat mass, along with decreased lean muscle mass, increased serum lipids, and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes. Latinos more often have obesity, dyslipidemia, low cardiovascular fitness, hypertension, and diabetes. Therefore, we propose to test our Staying Strong and Healthy program to promote healthy activity and nutrition during ADT for Latino men. Using a mixed methods design we aim to: 1. Compare pre- and post-intervention BMI, lipids, waist/hip circumference, and glucose within and between 75 Latino men starting ADT who are randomly assigned to receive the Staying Strong and Healthy intervention and 75 Latino men starting ADT randomly assigned to receive usual care. 2. Compare pre- and post- intervention HRQOL using the SF-12 subscales of emotional and physical well-being and disease-specific HRQOL using the Expanded Prostate Cancer Index Composite (EPIC) within and between groups. 3. Develop and compare explanatory models of Latino men's activity and nutrition choices between those receiving the intervention and those receiving usual care. 4. Evaluate acceptability and benefit of the intervention from perspective of participants. Latino men will be recruited form several sites serving predominantly Latino populations in Los Angeles. Men will come to UCLA Center for Translational Research for baseline, 6 and 12 months measures and interview at 12 months. Men assigned to the intervention group will receive initial assessment and education on nutrition and the exercised program immediately following baseline measures. They will then receive 12 weekly calls from a nurse coordinator/cultural liaison team to deliver focused information, establish individually tailored nutrition and activity goals, assess accomplishments of goals and provide support. We will conduct qualitative interview with 30 men from each group to assess the intervention from their perspective and to develop explanatory frameworks for decision process used relative to food and activity choices. Analysis will combine within and between group comparisons and grounded theory techniques.

描述（由申请人提供）：雄激素剥夺疗法（ADT）越来越多地用于治疗新辅助和辅助疗法的前列腺癌（RT），用于手术或放射线的初级治疗后复发，或者在前列腺癌处于晚期治疗。考虑到前列腺癌是美国男性最常见的皮肤癌，这变得非常重要。拉丁美洲人特别关心的是拉丁美洲人，因为拉丁美洲人是美国增长最快的少数群体（美国）。拉丁裔男性被诊断出患有后期疾病，使他们更有可能接受ADT治疗。研究表明，ADT上的男性患血管舒缩症状，抑郁症，疲劳，与健康相关的生活质量降低（HRQOL），骨矿物质密度（BMD）降低（BMD），性功能障碍，代谢综合征，脂肪质量的增加，以及较高的肌肉质量降低，较高的肌肉和较高的疾病，脂肪质量降低了，脂肪质量降低了。（CVD），骨质疏松症和II型糖尿病。拉丁美洲人经常患有肥胖症，血脂异常，低心血管健身，高血压和糖尿病。因此，我们建议测试我们坚强健康的计划，以促进拉丁裔男性在ADT期间促进健康的活动和营养。使用混合方法设计，我们的目的是：1。比较干预前和干预后的BMI，脂质，腰围/臀部周围和葡萄糖在内外的75名拉丁裔男性中，他们开始随机分配ADT，以随机分配以接受坚强健康的干预，以及75名拉丁裔男性开始随机分配ADT，从而随机分配了接受常规护理。 2。使用情绪和身体健康的SF-12分量表和疾病特异性的HRQOL比较前后的HRQOL，并使用群体内外的前列腺癌指数综合（EPIC）进行比较。 3。开发并比较接受干预措施的人与接受常规护理的人之间的拉丁裔男性活动和营养选择的解释模型。 4。从参与者的角度评估干预的可接受性和利益。拉丁裔男子将被招募，形成几个地点，在洛杉矶主要是拉丁裔人口。男子将来到加州大学洛杉矶分校的基线转化研究中心，6个月和12个月的措施，并在12个月时进行访谈。分配给干预小组的男性将在基线措施后立即接受有关营养的初步评估和营养和行使计划的教育。然后，他们将收到护士协调员/文化联络小组的每周12个电话，以提供专注的信息，建立单独量身定制的营养和活动目标，评估目标成就并提供支持。我们将对来自每个小组的30名男性进行定性访谈，以评估他们的角度的干预措施，并开发相对于食物和活动选择的决策过程的解释性框架。分析将结合组内和之间的比较和接地理论技术。