Comparison of kidney function measurement methods in the community

社区肾功能测量方法比较

基本信息

批准号：
7667448
负责人：
ANDREW David RULE
金额：
$ 13.77万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7667448
关键词：
Address Adult Affect Age Albuminuria American Appointment Arterial Disorder Attention Award Biometry Cardiovascular Diseases Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Kidney Failure Classification Clinic Clinical Research Collection Communities Creatinine Creatinine clearance measurement Cross-Sectional Studies Data Development Diabetes Mellitus Dialysis procedure Diet Modification Doctor of Medicine Early Diagnosis Environment Epidemiology Equation Excision General Population Glomerular Filtration Rate Gold Grant Hypertension Individual Individual Differences Inflammation Intake Intervention Iothalamate Joints Kidney Kidney Diseases Kidney Failure Knowledge Laboratories Lead Longitudinal Studies Master&apos s Degree Measurement Measures Medicine Mentors Mentorship Metabolic Methods Nephrology Patients Peer Review Persons Population Positioning Attribute Prevalence Prevention Proteins Race Renal function Research Research Personnel Resources Risk Risk Factors Sampling Serum Societies Staging Study of serum Surrogate Markers Testing Training Transplantation Tubular formation United States Urine Validation Work base cardiovascular disorder risk cardiovascular risk factor clinical practice cohort community setting coronary artery calcification disorder risk genetic epidemiology improved muscle form post gamma-globulins prevent professor programs sex symposium treatment strategy wasting

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.

描述（由申请人提供）：项目概要：候选人是一名肾脏病专家，于 2006 年 7 月 1 日开始在梅奥诊所担任职员。在过去 4 年的肾脏病学实习生中，候选人获得了临床研究硕士学位，第一作者 10 篇同行评审文章，并获得机构（T32）和个人（F32）国家研究奖。他在慢性肾脏病流行病学和肾功能方法方面的专业知识引起了全国的关注。他是疾病控制和预防中心的拨款审查员，并将主持美国肾脏病学会肾脏周（2006 年）的研讨会。该环境将包括罗切斯特梅奥诊所，他将在那里接受肾脏病学和流行病学联合预约。他的资助者、医学教授斯蒂芬·特纳（Stephen Turner）医学博士将为他提供数据访问权限，并培训他成为一名独立研究者。他的指导团队还将包括两名流行病学教授、一名生物统计学副教授以及肾功能实验室的联合主任，该实验室每年进行 5500 次“黄金标准”肾功能测量。该项目将比较金标准方法（碘酞酸盐清除率）和临床实践和大多数研究中使用的更方便但可能不太准确的方法（血清肌酐、胱抑素 C、估计方程和肌酐清除率）之间的肾功能测量结果。该项目的独特之处在于比较基于社区的样本（导师队列和候选人队列）中的这些肾功能方法。将确定肾功能测量方法对冠状动脉钙化的影响以及与慢性肾脏病相关的危险因素。相关性：在美国，800 万成年人的肾功能出现中度至重度下降，并面临昂贵的病态干预措施（透析或移植）和心血管疾病的风险。需要验证肾功能方法，以便在早期阶段识别慢性肾病、描述其危险因素并制定新的治疗策略。