LATE-LIFE DEPRESSION: NEUROBIOLOGICAL AND CLINICAL SUBSTRATES

晚年抑郁症：神经生物学和临床基础

• 批准号: 7606737
• 负责人: ANAND KUMAR
• 金额: $ 0.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-21 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606737
• 关键词: Biochemical; Biological; Choline; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Elderly; Funding; Grant; Institution; Lead; Lecithin; Magnetic Resonance Spectroscopy; Major Depressive Disorder; Measures; Medical; Mental Depression; N-acetylaspartate; Neurobiology; Primary Health Care; Protons; Research; Research Personnel; Resources; Risk Factors; Role; Source; United States National Institutes of Health; base; behavior measurement; cerebrovascular; geriatric depression; insight; morphometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MAJOR DEPRESSION. To examine the role of neuroanatomical changes and overall medical burden including cerebrovascular risk factors, in the development of major depression presenting at primary care/geriatric settings. A principal objective of our study is to integrate the neuroanatomical information with clincal and behavioral measures in order to obtain a more holistic picture of the neurobiologic basis of late-life MDD. In addition to morphometry, we propose to expand our MR approaches to include proton MR Spectroscopy (MRS), to examine revlevant biochemical measures such as N-Acetyl-L-Aspartate, Choline, Lecithin and myo-inosital (mI). Collectively these neuroanatomical, biochemical and clinical measures, will provide broader insights into the biological aberrations that lead to depression in late-life MDD.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 严重抑郁症。 研究神经解剖学变化和总体医疗负担（包括脑血管危险因素）在初级保健/老年病环境中重度抑郁症发展中的作用。 我们研究的主要目标是将神经解剖学信息与临床和行为测量相结合，以便更全面地了解晚年 MDD 的神经生物学基础。 除了形态测定之外，我们建议扩展我们的 MR 方法，包括质子 MR 光谱 (MRS)，以检查相关的生化指标，例如 N-乙酰基-L-天冬氨酸、胆碱、卵磷脂和肌肌醇 (mI)。 总的来说，这些神经解剖学、生化和临床测量将为导致晚年 MDD 抑郁症的生物畸变提供更广泛的见解。