THE CEREBROVASCULAR BASIS OF DEPRESSION IN NON INSULIN DEPENDENT DIABETES MEL

非胰岛素依赖型糖尿病梅尔抑郁症的脑血管基础

• 批准号: 7717966
• 负责人: ANAND KUMAR
• 金额: $ 0.89万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717966
• 关键词: Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diabetic Angiopathies; Functional disorder; Funding; Fundus photography; Grant; Institution; Lead; Lesion; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Pathway interactions; Patients; Research; Research Personnel; Resources; Retina; Retinal; Risk Factors; Role; Source; United States National Institutes of Health; base; brain volume; cerebrovascular; disturbance in affect; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: To examine the cerebrovascular basis of depression in patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM, type 2 diabetes). The precise role of microvascular disease in the pathophysiology of depression is unknown. Microvascular disease and depression coexist in patients with NIDDM, rendering it a unique clinical model in which to concurrently examine the role of structural abnormalities and microvascular disease in the pathophysiology of mood disturbances. Specific Aim 1: To examine the neuroanatomical correlates of depression in patients with NIDDM, we propose to use magnetic resonance imaging (MRI) to obtain volumetric estimates of brain volume and the volume of high intensity lesions in the parenchyma. Specific Aim 2: To estimate the volume of high intensity lesions in the brain parenchyma and microvascular disease in the retina, fundus photography will be utilized to estimate microvascular disease in the retina and retinal microangiopathy is conceptualized as a marker of microvascular disease in the brain. Specific Aim 3: To identify risk factors for depression and pathways that lead from clinical and neuroanatomical substrates to major depression, microvascular measures will be integrated with neuroanatomic indices in order to elucidate the pathways and mechanisms involved in the pathophysiology of depression in patients with NIDDM.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标： 旨在检查非胰岛素依赖型糖尿病（NIDDM，2 型糖尿病）患者抑郁症的脑血管基础。微血管疾病在抑郁症病理生理学中的确切作用尚不清楚。 NIDDM 患者的微血管疾病和抑郁症并存，使其成为一种独特的临床模型，可以同时检查结构异常和微血管疾病在情绪障碍的病理生理学中的作用。 具体目标 1：为了检查 NIDDM 患者抑郁症的神经解剖学相关性，我们建议使用磁共振成像 (MRI) 来获得脑体积和实质中高强度病变体积的体积估计。具体目标2：为了估计脑实质中高强度病变的体积和视网膜中的微血管疾病，将利用眼底摄影来估计视网膜中的微血管疾病，并且视网膜微血管病变被概念化为大脑中的微血管疾病的标志。 具体目标 3：为了确定抑郁症的危险因素以及从临床和神经解剖学基础导致重度抑郁症的途径，微血管测量将与神经解剖学指标相结合，以阐明 NIDDM 患者抑郁症病理生理学的途径和机制。