Personalized Bio-behavioral Weight Loss Intervention for African American Women

针对非裔美国女性的个性化生物行为减肥干预

• 批准号: 8383981
• 负责人: Gayenell Smith Magwood
• 金额: $ 9.07万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-18 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8383981
• 关键词: Address; Adult; Affect; African American; Age; Area; Behavior; Behavior Therapy; Behavioral; Behavioral Research; Behavioral Sciences; Biological Markers; Biological Sciences; Biometry; Body Weight decreased; Candidate Disease Gene; Collection; Communication; Communities; Community Developments; Complex; Data; Data Analyses; Databases; Development; Development Plans; Diet; Dietary Fats; Eating; Educational Curriculum; Energy Intake; Environment; Epidemiology; Exercise; Exhibits; Fatty acid glycerol esters; Funding; Future; Genes; Genetic; Genetic Databases; Genetic Variation; Genotype; Goals; Grant; Health; Individual; Intake; Intervention; Intervention Studies; Island; K-Series Research Career Programs; Knowledge; Lead; Life; Life Style; Manuscripts; Medical; Melanocortin 4 Receptor; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolic Pathway; Methodology; Methods; Minority; Mission; Modality; National Health and Nutrition Examination Survey; National Institute of Nursing Research; Neighborhoods; Not Hispanic or Latino; Obesity; Out-Migrations; Outcome; Overweight; Patient Self-Report; Penetration; Phase; Phenotype; Physical activity; Play; Population; Prevention Research; Production; Protocols documentation; Proxy; Public Health; Public Housing; Qualitative Methods; Randomized Controlled Trials; Registries; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk; Risk Reduction; Role; Sampling; Scientist; Sea; Senior Scientist; Sister; Socioeconomic Status; South Carolina; Stress; Testing; Training; United States; Universities; Weight; Woman; Writing; base; career; career development; community setting; design; diabetes prevention program; ethnic minority population; evidence base; genetic registry; genetic variant; health disparity; improved; innovation; interdisciplinary collaboration; intervention program; lipid metabolism; low density lipoprotein triglyceride; low socioeconomic status; meetings; new technology; novel; novel strategies; nutrition; obesity prevention; obesity treatment; preference; research and development; residence; response; skills; social; socioeconomics; theories; therapy development; treatment response; waist circumference; weight loss intervention

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Development Award proposal is designed to provide the scholarly training, mentorship, and resources necessary for the candidate to develop expertise in bio-behavioral research. The candidate's primary career goal is to become a funded independent investigator and recognized leader in the field of obesity prevention/treatment with expertise in developing personalized bio-behavioral weight loss interventions for African American (AA) women. To achieve this goal, a focused career development plan is proposed to: 1) Obtain knowledge and skills in understanding how genetic variants may be related to adiposity; modulate influence of lifestyle behaviors (i.e.PA, diet) upon changes in adiposity, and how these genotypes may eventually be used to help personalize behavioral interventions for obese AA women; 2) Obtain knowledge and skills in complex quantitative research methods, including bio-behavioral research designs and analyses, and advanced intervention development; and, 3) Enhance grant and scholarly writing skills, and manuscript production while continuing to build interdisciplinary collaboration with other researchers in the field of genetics, obesity and prevention research. The Medical University of South Carolina provides a comprehensive training environment that includes senior scientists with expertise in bio-behavioral interventions, genetics, and health disparities research. The candidate has a strong inter-professional and inter-institutional mentoring team with complementary expertise in the development of community based randomized controlled trials (RCT), genetics, obesity prevention and treatment, bio-behavioral interventions, biostatistics and epidemiology. The research plan, which builds on the training objectives, is directly responsive to the National Institute of Nursing Research's (NINR) mission of integrating the biological and behavioral sciences, employing new technologies to research questions, improving research methods, and developing the scientists of the future. The broad goal of this research is to identify key components for development of efficacious socio-culturally tailored behavioral interventions for long-term weight loss in low socioeconomic status (SES) obese AA women. The socio-cultural preferences will be incorporated into behavioral change strategies, the communication of genetic information, and the adaptation of the format and delivery of the evidence-based Diabetes Prevention Program materials and approaches to promote weight loss. To meet this goal, the candidate will conduct an exploratory study using genetic database secondary data analyses. Secondly, an intervention development phase, with 80 obese AA women living in public housing neighborhoods in the Charleston, SC region, to integrate new knowledge and skills from genetics while advancing skills in bio- behavioral research intervention development and methodology. The results of the proposed preliminary studies will inform a larger, adequately powered and resourced community based RCT for obese AA women that incorporates the use of genetic information and socio-cultural preferences to prescribe tailored weight loss strategies and promote long-term weight loss outcomes. PUBLIC HEALTH RELEVANCE: This innovative research plan addresses the need to integrate genetics, socio-environmental, and behavioral factors into promising multi-level community based interventions for disparate minority communities. Demonstrating that genetic and social-environmental components are important in designing and delivering obesity interventions is crucial. Further, gaining better understanding of predictors of obesity and obesity promoting behaviors in AA women could lead to changes in the selection and personalization of treatment approaches for obese AA women, and ultimately, improved outcomes for this population.

描述（由申请人提供）：该K01指导的研究科学家发展奖提案旨在提供学术培训，指导和资源，使候选人开发生物行为研究方面的专业知识所必需的资源。候选人的主要职业目标是成为肥胖症预防/治疗领域的一名资助的独立调查员，并在为非裔美国人（AA）妇女开发个性化的生物体重减肥干预措施方面具有专业知识。为了实现这一目标，提出了一项重点的职业发展计划：1）获得知识和技能，以了解遗传变异如何与肥胖有关；调节生活方式行为（即饮食）对肥胖变化的影响，以及这些基因型最终如何用于帮助个性化肥胖的AA妇女行为干预措施； 2）在复杂的定量研究方法中获得知识和技能，包括生物行为研究设计和分析以及高级干预开发； 3）在继续与遗传学，肥胖和预防研究领域的其他研究人员建立跨学科合作的同时，提高了赠款和学术写作技巧和手稿生产。南卡罗来纳州医科大学提供了一个全面的培训环境，其中包括具有生物行为干预，遗传学和健康差异研究方面具有专业知识的高级科学家。该候选人在基于社区的随机对照试验（RCT），遗传学，预防和治疗，生物行为干预，生物统计学和生物统计学和流行病学方面的发展方面拥有强大的专业间和机构间指导团队。基于培训目标的研究计划直接响应美国国家护理研究所（NINR）的使命，即整合生物学和行为科学，采用新技术来研究问题，改善研究方法，并发展未来的科学家。这项研究的广泛目标是确定开发有效的社会文化量身定制行为干预措施的关键组成部分，以减轻社会经济地位（SES）肥胖女性的长期体重减轻。社会文化偏好将纳入行为改变策略，遗传信息的交流以及对基于证据的糖尿病预防计划材料的适应和提供促进体重减轻的方法。为了实现这一目标，候选人将使用遗传数据库二级数据分析进行探索性研究。其次，一个干预发展阶段，有80名肥胖的AA妇女居住在南卡罗来纳州查尔斯顿地区的公共住房社区，以整合遗传学的新知识和技能，同时提高生物行为研究干预开发和方法论的技能。拟议的初步研究的结果将为肥胖的妇女提供更大的，充分的动力和资源的基于社区的RCT，该妇女纳入了使用遗传信息和社会文化偏好的使用，以开出定制的减肥策略并促进长期体重减轻的结果。 公共卫生相关性：这项创新的研究计划解决了将遗传学，社会环境和行为因素整合到有希望的不同社区干预措施中的必要性。证明遗传和社会环境组成部分对于设计和提供肥胖干预至关重要。此外，对AA妇女的肥胖和肥胖行为的预测有了更好的了解，可能会导致肥胖AA妇女的治疗方法的选择和个性化变化，并最终改善该人群的结果。