Clinical Studies Investigating Aggressive Behaviors And

调查攻击行为和

• 批准号: 7317742
• 负责人: David T George
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7317742
• 关键词: Clinical; Studies; Investigating; Aggressive; Behaviors

Preliminary results from a double blind study, comparing the effects of fluoxetine with placebo in a carefully selected group of 67 perpetrators of domestic violence, show that both abstinence from alcohol and the administration of fluoxetine decrease the likelihood that perpetrators will be aggressive. During the past year accrual for the protocol has been completed and we are in the process of performing the data analysis. In this analysis we will be examining the effect of fluoxetine on aggression, alcohol consumption, mood, emotional expressions during interactions with their spouse/significant others, and response to emotional stimuli using functional MRI (fMRI). It is hoped that the results from this study will: 1) help us to better understand the interaction between alcohol and aggression, and 2) lead to new forms of treatment for alcohol dependent individuals who have a history of domestic violence.

双盲研究的初步结果，将氟西汀与安慰剂的作用与安慰剂的作用在精心挑选的67个家庭暴力犯罪者中进行了比较，这表明，酒精的禁欲和氟西汀的给药都降低了犯罪者的可能性。在过去的一年中，该协议的应计完成，我们正在执行数据分析。在此分析中，我们将研究氟西汀对与配偶/重要其他人相互作用的侵略性，饮酒，情绪，情绪表达的影响，并使用功能性MRI（fMRI）对情绪刺激的反应。希望这项研究的结果能够：1）帮助我们更好地了解酒精与侵略性之间的相互作用，以及2）为有家庭暴力史的依赖酒精的人提供新的治疗形式。