YOHIMBINE CHALLENGE TO STUDY NORADRENERGIC FUNCTION IN INDIVIDUALS

育亨宾挑战研究个体去甲肾上腺素能功能

• 批准号: 6097574
• 负责人: David T George
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6097574
• 关键词: arousal; autonomic nervous system; behavioral /social science research tag; clinical research; human subject; locus of control; psychopharmacology; spouse abuse; violence; yohimbine

Domestic violence is a major problem affecting society. Results from our research show that individuals who are physically abusive to their significant other frequently experience a hyperaroused state at the time of the violent act which is characterized by increased motor activity, heightened autonomic nervous system activity and accompanied by feelings of "being out of control". This hyperaroused state is similar to that which occurs in Post Traumatic Stress Disorder (PTSD). Since PTSD has been associated with changes in noradrenergic function, (1) we postulate that subjects who lose control and are physically violent may also have abnormal noradrenergic function. To test this hypothesis, we have designed a study which compares the behavioral and biochemical effects resulting from the administration of the alpha-2 antagonist, yohimbine between a group of patients who lose control and are physically violent and non-violent comparison subjects. To date there have been no untoward effects. Results will be analysed when sufficient subjects have been accrued to allow meaningful results.

家庭暴力是影响家庭的一个主要问题 社会。我们的研究结果表明，那些 经常对他们的重要他人进行身体虐待 暴力行为发生时的过度兴奋状态 其特点是运动活动增加、自主神经增强 神经系统活动并伴有“外出”的感觉 控制”。这种过度兴奋的状态类似于发生的情况 创伤后应激障碍（PTSD）。自从 PTSD 以来 与去甲肾上腺素能功能的变化相关，（1）我们假设 失去控制和身体暴力的受试者也可能 去甲肾上腺素能功能异常。为了检验这个假设，我们 设计了一项研究来比较行为和 施用 alpha-2 产生的生化效应 拮抗剂，育亨宾在一组失去控制的患者之间 是身体暴力和非暴力的比较对象。到 迄今为止，没有出现任何不良影响。将分析结果 当已经积累了足够的科目以允许有意义的 结果。