Establishing the PhenX Toolkit as a Biomedical Knowledgebase

将 PhenX 工具包建立为生物医学知识库

• 批准号: 10807362
• 负责人: Carol Marie Hamilton
• 金额: $ 38.49万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807362
• 关键词: Address; Administrative Supplement; Adolescent; Adoption; Alcohol consumption; All of Us Research Program; Award; Awareness; Biological Assay; Blood; Brain; COVID-19; Catalogs; Child Health; Clinical Research; Collaborations; Collection; Common Data Element; Communities; Complex; Consensus; Data; Data Collection; Development; Disease; Enrollment; Ensure; Etiology; Funding; Funding Opportunities; Future; Genetic Diseases; Genomics; Goals; Health; Human; Individual; International; Language; Link; Logical Observation Identifiers Names and Codes; Longitudinal Studies; Measurement; Measures; Medical Marijuana; Mental Health; National Health and Nutrition Examination Survey; National Human Genome Research Institute; National Institute of Drug Abuse; Online Systems; Outcome; Parents; Participant; Patient Care; PhenX Toolkit; Phenotype; Population Assessment of Tobacco and Health; Process; Protocols documentation; Quality of life; Questionnaires; Recommendation; Recovery; Research; Research Design; Research Personnel; Research Support; Resources; Science; Source; Stigmatization; Substance Addiction; Substance Use Disorder; Substance abuse problem; Time; Tobacco; Translational Research; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Update; Work; World Health Organization; bioinformatics tool; cognitive development; data sharing; database of Genotypes and Phenotypes; electronic data; epidemiology study; genome wide association study; human disease; improved; knowledgebase; marijuana use; medical specialties; polysubstance use; repository; response; social health determinants; standard measure; substance use; translational study; volunteer; working group

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes, and quality of life. To this end, PhenX has established a freely available, web-based catalog of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. The research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. Specifically, this administrative supplement will expand the Toolkit to address medical cannabis use, polysubstance use, and recovery. The specific aims of this administrative supplement are to (1) review and adjust stigmatizing language in the Substance Abuse and Additions (SAA) collections, (2) identify pertinent linkages among SAA measurement protocols and other protocols in the PhenX Toolkit, (3) address gaps in SAA coverage related to Medical Cannabis Use, Polysubstance Use, and Recovery, and (4) disseminate results to the scientific community. This effort will support NIDA-funded initiatives, raise awareness of the Toolkit as a valuable resource, and attract additional users to the Toolkit. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies.

项目摘要/摘要 苯克斯的目标（表型和暴露的共识度量）是为研究人员提供 使用标准测量方案（例如问卷，生物测定，物理测量）来改进 数据收集的质量和一致性并增加了个别研究的影响。随着时间的流逝，这个 普通货币将使研究人员更容易地结合研究以增加统计能力和 比较研究以验证发现。实现共享数据的分析应导致更好 了解人类疾病的病因，进展和治疗，最终导致 改善患者护理，健康成果和生活质量。为此，苯克斯已经建立了 可免费获得的，基于网络的测量协议目录，用于基因组，临床， 与人类参与者的翻译和流行病学研究。苯苯苯苯克工具包的内容和 特征是由科学界驱动的。苯克斯指导委员会（SC）提供了总体 苯克斯工具包中的指导和每个测量协议由工作组（WG）选择 专家使用基于共识的过程依赖科学界的意见。 该研究计划将建立苯克斯工具包，作为组织的可持续知识库 积累并注释标准协议并将其链接到相关资源和数据。具体来说， 这种行政补充剂将扩大工具包，以解决医用大麻的使用，polysubstance使用， 和恢复。这种行政补充的具体目的是（1）审查和调整污名化 药物滥用和添加的语言（SAA）集合，（2）确定相关的联系 SAA测量协议和苯克斯工具包中的其他协议，（3）解决SAA覆盖范围中的差距 与医用大麻的使用，多物质使用和恢复有关，以及（4）将结果传播到 科学界。这项努力将支持NIDA资助的计划，提高对工具包的认识 宝贵的资源，并吸引更多用户进入工具包。广泛采用苯苯甲酸苯甲 促进跨研究分析，从而增加了个体研究的科学影响。