Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 Research

PhenX 工具包的基因组资源资助 - 扩展和可持续性PhenX 针对 COVID-19 研究的补充

• 批准号: 10179036
• 负责人: Carol Marie Hamilton
• 金额: $ 95.5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179036
• 关键词: Administrative Supplement; Adolescent; All of Us Research Program; Area; Award; Awareness; Bioinformatics; Biomedical Research; Brain; COVID-19; Catalogs; Child Health; Clinical Research; Collaborations; Collection; Common Data Element; Communities; Community Outreach; Complex; Consensus; Data; Data Collection; Data Pooling; Development; Disease; Enrollment; Ensure; Epidemiologist; Etiology; Genetic Diseases; Genomics; Grant; International; Intervention; Logical Observation Identifiers Names and Codes; Longitudinal Studies; Measurement; Measures; Mental Health; Meta-Analysis; National Human Genome Research Institute; Outcome; Phenotype; Process; Protocols documentation; Recommendation; Reproducibility of Results; Research; Research Design; Research Methodology; Research Personnel; Resources; Science; Sickle Cell Anemia; Social Distance; Source; Symptoms; Text; Tobacco; Translational Research; U-Series Cooperative Agreements; United States; United States National Library of Medicine; Vaccines; base; behavioral/social science; bioinformatics tool; cognitive development; crowdsourcing; data dictionary; data harmonization; data interoperability; data sharing; database of Genotypes and Phenotypes; electronic data; genome wide association study; genome-wide analysis; improved; medical specialties; member; multidisciplinary; recruit; response; social science research; standard measure; tool; usability; volunteer; working group

PROJECT SUMMARY/ABSTRACT Biomedical science in the 21st century is a multidisciplinary and data-intensive enterprise that relies on clear specification of research methods and results. The reproducibility of findings and the meta-analysis of pooled data from disparate sources are both catalyzed by standard approaches to acquiring and representing data. In this context, the PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) is an increasingly valuable catalog of standard measures and bioinformatics tools that help investigators improve the quality and consistency of data collection and identify opportunities for collaborative research. Measures in the PhenX Toolkit are selected by working groups (WGs) of domain experts using a consensus process and criteria established by the PhenX Steering Committee (SC). Since its launch, PhenX has expanded beyond standard measures for genome-wide association studies (GWAS) of common, complex diseases to include domains such as Rare Genetic Conditions, Sickle Cell Disease, and Tobacco Regulatory Research. The specific aims of the proposed Administrative Supplement “PhenX Measures for COVID-19” are as follows: Specific Aim 1: Develop COVID-19 Core and Specialty collections. Specific Aim 2: Develop features and tools for the COVID-19 page. Specific Aim 3: Establish PhenX measurement protocols for COVID-19 outcomes. The crowd-sourcing approach defined here will rapidly establish COVID-19 Core and Specialty Collections and raise awareness of the COVID-19 measurement protocols available in the PhenX Toolkit.Body Text (no more than 30 lines)

项目摘要/摘要 21世纪的生物医学科学是一家多学科和数据密集型企业，依赖于清晰的 研究方法和结果的规范。发现的可重复性和合并的荟萃分析 来自不同来源的数据都通过标准方法来催化和表示数据。 在这种情况下，苯苯二类（表型和暴露的共识度量）工具包 （https://www.phenxtoolkit.org/）是标准测量和生物信息学的越来越有价值的目录 帮助调查人员提高数据收集的质量和一致性并确定机会的工具 进行协作研究。苯克斯工具包中的措施由域的工作组（WGS）选择 专家使用苯苯克指导委员会（SC）建立的共识过程和标准。自从 它的发射，苯克斯超出了全基因组关联研究（GWAS）的标准措施的扩展。 常见的复杂疾病，包括诸如罕见遗传状况，镰状细胞疾病等领域， 和烟草监管研究。 拟议的行政补充“ Covid-19”的具体目的是 以下内容：特定目标1：开发Covid-19-19核心和专业集合。特定目标2：开发功能 和COVID-19页的工具。特定目的3：建立COVID-19 结果。 这里定义的众包方法将迅速建立Covid-19核心和专业收藏 并提高对苯苯克工具包中可用的COVID-19测量协议的认识。 超过30行）