Establishing the PhenX Toolkit as a Biomedical Knowledgebase

将 PhenX 工具包建立为生物医学知识库

• 批准号: 10707376
• 负责人: Carol Marie Hamilton
• 金额: $ 175万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707376
• 关键词: Address; Adoption; Area; Awareness; Bioinformatics; Biological Assay; Biomedical Research; Blood; COVID-19; Catalogs; Clinical Research; Collection; Common Data Element; Communities; Consensus; Data; Data Collection; Educational Materials; Electronic Health Record; Ensure; Etiology; Exposure to; Fast Healthcare Interoperability Resources; Focus Groups; Funding Opportunities; Genome; Genomics; Goals; Health; Health Status; Human; Individual; International; Link; Logical Observation Identifiers Names and Codes; Measurement; Measures; National Human Genome Research Institute; National Institute on Minority Health and Health Disparities; Online Systems; Outcome; Participant; Patient Care; PhenX Toolkit; Phenotype; Process; Protocols documentation; Quality of life; Questionnaires; RADx Underserved Populations; Recommendation; Research; Research Personnel; Researching COVID to Enhance Recovery; Resources; Science; Scientist; Site; Strategic vision; Substance Addiction; Substance abuse problem; Time; Translational Research; United States National Institutes of Health; United States National Library of Medicine; Update; biomedical resource; career; data sharing; database of Genotypes and Phenotypes; electronic data; epidemiology study; human disease; improved; interoperability; knowledgebase; medical specialties; outreach; response; social health determinants; working group

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes and quality of life. To this end, PhenX has established a freely available, Web-based catalog (https://www.phenxtoolkit.org/) of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. Initially released in 2009, the PhenX Toolkit currently includes 874 protocols addressing human phenotypes and exposures. In the next 5 years, PhenX will expand the breadth and depth of the Toolkit, increase utility, and strive to increase awareness of the resource. The Specific Aims are to (1) review, update, and expand PhenX Toolkit content; (2) leverage biomedical standards to increase scientific impact of PhenX Toolkit; and (3) raise awareness and increase adoption of the PhenX Toolkit. This research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. This plan, which reflects a multipronged approach, will ensure that the value and impact of the PhenX Toolkit will continue to increase over time.

项目摘要/摘要 苯克斯的目标（表型和暴露的共识度量）是为研究人员提供 标准测量方案（例如，问卷，生物测定，物理测量）以改进 数据收集的质量和一致性并增加了个别研究的影响。随着时间的流逝，这个 普通货币将使研究人员更容易地结合研究以增加统计能力和 比较研究以验证发现。实现共享数据的分析应导致更好的理解 人类疾病的病因，进展和治疗，最终导致患者的改善 护理，健康成果和生活质量。为此，苯克斯已经建立了一个免费的，基于网络的 目录（https://www.phenxtoolkit.org/）的测量方案用于基因组，临床， 与人类参与者的翻译和流行病学研究。苯苯苯苯克工具包的内容和 特征是由科学界驱动的。苯克斯指导委员会（SC）提供了总体 苯克斯工具包中的指导和每个测量协议由工作组（WG）选择 专家使用基于共识的过程依赖科学界的意见。最初 苯克斯工具包于2009年发行，目前包括874个协议，以解决人类表型和 暴露。在接下来的五年中，苯二苯克斯将扩大工具包的宽度和深度，增加效用，并扩大 努力提高对资源的认识。具体目的是（1）审查，更新和扩展 苯苯苯克斯工具包含量； （2）利用生物医学标准来增加苯苯克工具包的科学影响； （3）提高意识并增加对苯苯苯苯苯苯克工具包的采用。该研究计划将建立 苯克斯工具包是一种可持续的知识基础，该知识基础组织，积累和注释标准 协议并将其链接到相关资源和数据。这个计划反映了一种多收益的方法， 将确保随着时间的流逝，苯克斯工具包的价值和影响将继续增加。