Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP)in rats (after perinatal exposure)

进行研究以评估异丙基磷酸苯酚 (IPP) 和磷酸三苯酯 (TPHP) 对大鼠的亚慢性和发育神经毒性（围产期暴露后）

• 批准号: 10788075
• 负责人: Barney Sparrow
• 金额: $ 198.5万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788075
• 关键词: Adverse effects; Chemicals; Data; Development; Dose; Environment; Environmental Exposure; Evaluation; Exposure to; Flame Retardants; General Population; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Lactation; Mission; Perinatal Exposure; Phenols; Pregnancy; Rattus; Risk Assessment; Toxic effect; Toxicity Tests; Toxicology; Weaning; consumer product; design; developmental neurotoxicity; developmental toxicity; disorder prevention; inorganic phosphate; public health research; sound

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP) in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. IPP and TPHP are aromatic organo phosphate flame retardants. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to IPP and TPHP occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of IPP and TPHP and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant

该项目的目的是提供旨在预防疾病或由环境暴露于化学物质或物理药物引起的疾病或不良影响的危险识别活动的支持。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要正确进行毒理学研究，以确保所得数据可靠。该项目涉及通过剂量饲料暴露后，大鼠中异丙基化苯酚（IPP）和磷酸三苯基（TPHP）的毒性研究；妊娠和泌乳期间以及断奶后三个月发生暴露。 IPP和TPHP是芳香的有机磷酸盐阻燃剂。预计使用会增加，因为此类将取代其他类别的阻燃剂。 IPP和TPHP的接触在普通人群中通过其在消费产品和环境中的存在。该项目的数据将用于开发有关IPP和TPHP潜在毒性的声音，科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。 关键字：毒性，异丙基化苯酚磷酸盐，剂量饲料，阻燃剂