3rd US/EU Conference on Repair of Endogenous Genome Damage

第三届美国/欧盟内源基因组损伤修复会议

• 批准号: 7541289
• 负责人: Sankar Mitra
• 金额: $ 1.3万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7541289
• 关键词: Aging; Applications Grants; Area; Back; Cell Cycle; Cell Differentiation process; Chromatin Structure; Country; DNA Damage; Disease; Excision; Functional disorder; Future; Genome; Lesion; Location; Malignant Neoplasms; Medical; Minority Groups; Nuclear; Oral; Participant; Pathway interactions; Process; Proteins; Research Personnel; Role; Scientist; Series; Sicily; Single Strand Break Repair; Texas; Tissues; Universities; Virginia; Woman; age related; base; cell type; day; medical schools; mitochondrial genome; posters; repaired; success; symposium

DESCRIPTION (provided by applicant): This R13 Conference grant proposal requests partial support for the 3rd US/EU Conference titled, "Repair of Endogenous Genome Damage". The broad objective of this Conference series is to promote discussion among scientists from US and EU countries about the recent advancements in processing of endogenous DNA damage (mostly oxidative) including repair and their role in cancer, other pathophysiologies and aging. An important objective of our meeting is exploration of collaborative efforts particularly among young investigators in two continents. The series was initiated with a meeting in Virginia in 2003 with great success. It was decided then that this conference series will continue to be held in alternate years and the venue will switch between a location in US and an EU country. Thus the 2nd conference was held in Sicily in November, 2005. For unavoidable reasons, the 3rd US/EU conference planned for 2007 was pushed back to November 5-9, 2008, and will be held in Moody Gardens Conference Center, Galveston, TX. The University of Texas Medical Branch in Galveston, the oldest medical school in Texas, will be a co-sponsor of this conference. The 4-day meeting will be attended by a little more than 100 participants including 45 invited speakers and session chairs, with equal representation from the US and EU. Special emphasis is placed on inclusion of young investigators both among invited speakers and poster presenters. Some of the posters will be selected for short oral presentation. Particular efforts will be made to include women and minority group scientists as speakers and other participants. The focus of this meeting is distinct from that of other, similar meetings because of its rather narrow focus on endogenous DNA damages. These damages are repaired primarily via the base excision and single- strand break repair (BER/SSBR) pathway. Multiple subpathways of BER/SSBR have evolved to process diverge damages. Furthermore, repair is regulated by multiple parameters, including tissue and cell types, cell cycle, cell differentiation, location of lesions in the genome and chromatin structures. New discoveries made in these areas and diseases due to repair deficiency identified since the meeting in 2005 will be discussed. Recent studies have suggested the existence of the BER interactome where the repair proteins interact with one another in a coordinated fashion. Age-dependent changes in repair of nuclear and mitochondrial genomes will also be covered. Comprehensive characterization of the repair processes should have significant translational implications. Finally, this conference devoted to discussion of the current state of our understanding, future directions and challenges by the leaders should be beneficial to the junior investigators in the repair field.

描述（由申请人提供）：此 R13 会议拨款提案请求为题为“修复内源基因组损伤”的第三届美国/欧盟会议提供部分支持。该会议系列的总体目标是促进来自美国和欧盟国家的科学家就内源性 DNA 损伤（主要是氧化损伤）处理（包括修复）及其在癌症、其他病理生理学和衰老中的作用的最新进展进行讨论。我们会议的一个重要目标是探索合作努力，特别是在两大洲的年轻研究人员之间。该系列活动于 2003 年在弗吉尼亚州举行的一次会议上启动，并取得了巨大成功。随后决定，该系列会议将继续隔年举行，地点将在美国和欧盟国家之间切换。因此，第二次会议于2005年11月在西西里岛举行。由于不可避免的原因，原定于2007年举行的第三次美国/欧盟会议推迟到2008年11月5日至9日，并在德克萨斯州加尔维斯顿穆迪花园会议中心举行。位于加尔维斯顿的德克萨斯大学医学分院是德克萨斯州最古老的医学院，将成为本次会议的共同主办方。为期 4 天的会议将有 100 多名与会者参加，其中包括 45 名受邀演讲者和会议主席，其中美国和欧盟的代表人数相等。特别强调将年轻研究者纳入受邀演讲者和海报展示者之中。一些海报将被选中进行简短的口头展示。将特别努力让妇女和少数群体科学家作为发言者和其他参与者。 这次会议的重点与其他类似会议不同，因为它的关注范围相当狭窄，集中于内源性 DNA 损伤。这些损伤主要通过碱基切除和单链断裂修复（BER/SSBR）途径修复。 BER/SSBR 的多个子路径已经发展到可以处理不同的损坏。此外，修复受到多个参数的调节，包括组织和细胞类型、细胞周期、细胞分化、基因组中病变的位置和染色质结构。将讨论自 2005 年会议以来在这些领域取得的新发现以及因修复缺陷而发现的疾病。最近的研究表明 BER 相互作用组的存在，其中修复蛋白以协调的方式相互作用。还将涵盖核和线粒体基因组修复的年龄依赖性变化。修复过程的综合表征应该具有重大的转化意义。最后，这次会议专门讨论了我们的认识现状、未来的方向和挑战，对于维修领域的初级研究人员应该是有益的。