2023 Polyamines Gordon Research Conference and Gordon Research Seminar

2023年多胺戈登研究会议暨戈登研究研讨会

• 批准号: 10675969
• 负责人: ANDRE S BACHMANN
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-25 至 2023-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675969
• 关键词: Academia; Adult; Aging; Alzheimer' s Disease; Amino Acids; Antineoplastic Agents; Applications Grants; Area; Asia; Basic Science; Biological Markers; Biological Models; Biology; Biotechnology; COVID-19 pandemic; Cancer Biology; Cancer Prevention Trial; Cell physiology; Cells; Childhood; Childhood Neurological Disorder; Clinic; Clinical; Clinical Trials; Collaborations; Colon Carcinoma; Communities; DL-alpha-Difluoromethylornithine; Degenerative Disorder; Development; Diabetes Mellitus; Discipline; Disease; Disorder of neurometabolic regulation; Drosophila genus; Drug Targeting; Environment; Epigenetic Process; Europe; FDA approved; Female; Fostering; Funding; Future; Genes; Genetic Transcription; Goals; Grant; Home; Human; Immunobiology; Immunologic Surveillance; Infection; Infusion procedures; Ion Channel; Life; Link; Location; Malignant Neoplasms; Malignant neoplasm of prostate; Mammals; Metabolic; Metabolic Diseases; Metabolism; Names; Natural Products; Neoplasm Metastasis; Neuroblastoma; Neurodevelopmental Disorder; Organism; Outcome; Parasites; Parasitic infection; Participant; Pathway interactions; Pediatric Oncology Group; Pharmaceutical Chemistry; Pharmacologic Substance; Phase I/II Clinical Trial; Physicians; Plants; Play; Polyamines; Postdoctoral Fellow; Prevention; Productivity; Prokaryotic Cells; Proteins; Randomized; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Running; Scientist; Series; Structural Biologist; Students; Syndrome; Training; Translational Research; Translations; Travel; United States National Institutes of Health; Vertebrates; Virulent; Work; Writing; bench to bedside; cancer chemoprevention; cancer clinical trial; cancer prevention; cancer therapy; career; career development; cost; data exchange; drug discovery; eIF-5A; experience; forging; gain of function mutation; graduate student; human disease; inhibitor; male; meetings; member; microbiome; multidisciplinary; next generation; pathogen; phase II trial; polycation; posters; programs; stemness; success; symposium; translational impact; tumor metabolism; tumorigenesis

Project Summary The Polyamines Gordon Research Conference (GRC) has run continuously since 1975 and provides a multidisciplinary forum that brings together leading polyamine researchers as well as young and established investigators new to the field. The 2023 Polyamines GRC will be held at Waterville Valley Resort in NH, from June 25-30, 2023. This GRC will have a broad focus on the role of polyamines in human diseases, with a major focus on cancer including breakthroughs in cancer metabolism and immune surveillance, advanced clinical trials for cancer prevention & treatment, metastasis and cancer stemness, protein translation, and medicinal chemistry-based cancer drug discovery. Other human diseases include several recently discovered inborn metabolic neurodevelopmental disorders linked to polyamine genes, diabetes, degenerative disorders, and pathogens. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2023 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, physician- scientists, and clinicians, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and new diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 28 named speakers, 22 are new since the last GRC and have never spoken and/or are early career scientists. We will also choose 5 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 42 GRC & 15 GRS registrations, and travel costs for 15 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to enhance the training of young scientists from diverse backgrounds to become contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 8th Polyamines, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, by promoting young scientists during the main conference. Interactions between GRS & GRC conferees facilitate sharing of ideas and create new partnerships that will drive the field forward.

项目概要 多胺戈登研究会议 (GRC) 自 1975 年以来一直持续举办，并提供了 多学科论坛汇聚了领先的多胺研究人员以及年轻和成熟的研究人员 新进入该领域的调查人员。 2023 年 Polyamines GRC 将于新罕布什尔州沃特维尔谷度假村 (Waterville Valley Resort) 举行，从 2023 年 6 月 25-30 日。本次 GRC 将广泛关注多胺在人类疾病中的作用， 主要关注癌症，包括癌症代谢和免疫监测方面的突破，先进 癌症预防和治疗、转移和癌症干细胞、蛋白质翻译等临床试验 基于药物化学的癌症药物发现。其他人类疾病包括最近发现的几种 与多胺基因、糖尿病、退行性疾病相关的先天性代谢神经发育障碍， 和病原体。这次会议的独特之处在于它吸引了各种各样的顶级研究人员来评估 多胺在广泛的模型系统（原核生物、寄生虫、 果蝇、植物、脊椎动物和哺乳动物）。多胺是一种小的氨基酸衍生的聚阳离子，存在于 所有形式的生命体，在许多细胞过程中发挥着重要作用，包括转录、翻译、 复制、代谢、表观遗传控制和离子通道功能。 2023 年多胺 GRC 将 强调针对癌症和其他疾病的多胺途径。该计划具有强大的组合 基础、转化和临床研究人员。参加这次 GRC 的有生物学家、化学家、医生—— 科学家和临床医生，包括来自学术界、生物技术和制药领域的研究人员。这 科学学科的多样性在 GRC 中是独一无二的，具有高度的刺激性，并将强调新的发现 与上游和下游途径有关，以及最近才与改变相关的新疾病 多胺生物学。我们将带来最新的研究、新的研究人员到该领域以及早期职业研究人员 到这个论坛。在 28 名指定发言者中，有 22 名是自上次 GRC 以来的新人，从未发言过和/或正在发言。 早期职业科学家。我们还将从戈登研究研讨会（GRS）和 海报，这将增加更多新的演讲者。具体目标是寻求获得资金支持 42 GRC 和 15 GRS 注册以及 15 名 GRC/GRS 参与者的差旅费。长期目标是加强 了解多胺代谢与人类疾病之间的相互作用，并增强 培训来自不同背景的年轻科学家成为多胺的贡献成员 科学界。受邀演讲者的演讲时间为 25-30 分钟，并有 10 分钟的讨论。 GRC 将与第八届 Polyamines 同期举行，为研究生和研究员提供 学生经营的场所，促进数据和思想的交流。 GRS 使 GRC 成为更丰富的体验， 在主会议期间宣传年轻科学家。 GRS 和 GRC 与会者之间的互动促进 分享想法并建立新的伙伴关系，推动该领域向前发展。