A Multi-Method Investigation of Tonic Immobility and Implications for Trauma-Related Disorders

强直不动及其对创伤相关疾病影响的多方法研究

• 批准号: 10730549
• 负责人: Danielle Marie Morabito
• 金额: $ 3.95万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-05 至 2024-07-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10730549
• 关键词: Adult; Animal Experimentation; Animal Model; Animals; Appointment; Attention; Autobiography; Behavior; Behavior assessment; Behavioral; Cessation of life; Clinical; Consent; Data; Data Reporting; Detection; Diagnosis; Disease; Dissociation; Electroencephalography; Eligibility Determination; Emotions; Event-Related Potentials; Female; Freezing; Fright; Future; Goals; Health; Heart Rate; Hour; Human; Image; Immobilization; Individual; Individual Differences; Injury; Interview; Investigation; Knowledge; Laboratories; Link; Literature; Maintenance; Measures; Mental Health; Methodology; Methods; Military Personnel; Modeling; National Institute of Mental Health; Nature; Participant; Patient Self-Report; Pattern; Physiological; Populations at Risk; Post-Traumatic Stress Disorders; Posture; Psychopathology; Public Health; Questionnaires; Reaction; Reporting; Research; Research Domain Criteria; Research Personnel; Reverse engineering; Risk; Statistical Methods; Stimulus; Structure; Survivors; Symptoms; Tonic Immobility Response; Training; Trauma; Work; active duty; behavior measurement; clinical diagnosis; combat; experience; experimental study; fighting; first responder; graduate student; indexing; insight; neural; neurophysiology; physical conditioning; preventive intervention; response; sexual assault; skills; trauma exposure; traumatic event

Project Summary. Extant research on animal and human threat responding has identified adaptive ways of managing threat (i.e. fight-flight-freeze). Although freezing in response to threat may be adaptive in certain circumstances, it can also reduce chances of escape, resulting in increased physical and mental health risk. Despite its importance, research on human freeze responding is highly limited due to lack of integration across levels of analysis. While the majority of studies use retrospective self-report measures of tonic immobility (TI) that were reverse engineered from anecdotal reports of freezing in response to traumatic events such as sexual assault and combat, experimental studies of freeze response in humans evolved from animal research paradigms. Thus, examination of human immobility in response to threat currently relies on retrospective self- report or behavioral data alone, making it difficult to integrate and compare findings across studies. Additionally, though animal research suggests a link between freezing and alterations in threat processing, research has not yet begun to examine the neural basis of human immobility in response to threat. The P1 and LPP event-related potentials (ERPs), which have been reliably associated with attention to threat and threat processing, may provide insight into the nature and impact of freeze responses including TI. Taken together, the overall aim of the current proposal is to examine immobility in response to threat and its relationship with trauma related psychopathology across multiple levels of analysis, consistent with the NIMH RDoC initiative. The proposed study will 1) develop a unified index of TI utilizing a lab-based experimental threat paradigm to assess behavioral and self-report markers of immobility, 2) investigate the neural markers associated with immobility in response to threat (i.e. P1, LPP), and 3) examine the associations between prior TI exposure, lab- induced immobility, and psychopathology across individuals and groups. Adult female participants (N = 180) including individuals with prior TI, prior trauma exposure without TI, and healthy controls will complete one three-hour lab appointment after determination of initial eligibility and consent. Trained doctoral level graduate students will administer structured clinical interviews (SCID-5-RV) to determine eligibility and diagnoses. Then, participants will complete a self-report questionnaire battery followed by two experimental tasks. Previously validated image viewing and autobiographical script tasks will be used to elicit immobility responses. Behavioral (postural sway, heart rate), neurophysiological (EEG/ERP), and self-report data will be collected. The proposed study will serve to inform future research, preventative interventions, and treatment of trauma- related disorders. Another key aspect of this proposal will be in the training that the primary investigator (PI) receives. This training will provide the PI with the necessary skills to integrate neurophysiological and advanced statistical methods into future work.

项目摘要。关于动物和人类威胁反应的现有研究已经确定了适应性的方式 管理威胁（即战斗冻结）。尽管响应威胁的冻结可能是适应性的 情况，它也可以减少逃生的机会，从而增加身心健康的风险。 尽管它很重要，但由于缺乏整合整合的整合，对人类冻结响应的研究受到了极大的限制 分析水平。而大多数研究都使用回顾性的自我报告措施（TI） 这是根据响应创伤事件（例如 性侵犯和战斗，人类冻结反应的实验研究，从动物研究中进化出来 范式。因此，目前对威胁的人类暂停性的检查依赖于回顾性自我 仅报告或行为数据，因此很难整合和比较跨研究的发现。 此外，尽管动物研究表明冻结与威胁处理的改变之间有联系，但 研究尚未开始检查对威胁的人类暂不动用的神经基础。 P1和 LPP与事件相关的电位（ERP），与对威胁和威胁的关注可靠地相关 处理可能会深入了解包括Ti在内的冻结反应的性质和影响。在一起， 当前提案的总体目的是检查对威胁及其与其与之的关系的不动性 与NIMH RDOC倡议一致的多个分析层次的创伤相关的心理病理学。 拟议的研究将1）开发一个利用基于实验室的实验威胁范式的统一指数 评估不动行为和自我报告标记，2）研究与 响应威胁（即P1，LPP）和3）检查先前暴露，实验室之间的关联 跨个体和群体诱导的固定性和心理病理学。成年女性参与者（n = 180） 包括先前Ti的人，没有Ti的先前创伤暴露，健康对照将完成一个 确定初始资格和同意后的三小时实验室任命。训练有素的博士毕业生 学生将管理结构化的临床访谈（SCID-5-RV），以确定资格和诊断。然后， 参与者将完成自我报告问卷调查电池，然后完成两项实验任务。之前 经过验证的图像查看和自传脚本任务将用于引起固定响应。 将收集行为（姿势摇摆，心率），神经生理学（EEG/ERP）和自我报告数据。 拟议的研究将有助于为未来的研究，预防性干预以及创伤的治疗提供信息。 相关疾病。该提案的另一个关键方面将是主要研究人员（PI）的培训。 收到。该培训将为PI提供整合神经生理学和的必要技能 先进的统计方法进入未来的工作。