Effective Network to advance Scientific Evidence related to Mechanisms of music-Based interventions (ENSEMBLE)

有效网络推进与音乐干预机制相关的科学证据（ENSEMBLE）

基本信息

批准号：
10765160
负责人：
Manoj Bhasin
金额：
$ 52.62万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-21 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10765160
关键词：
Address Adult Affect Anxiety Applications Grants Area Biological Biological Markers Board Certification California Caring Clinical Clinical Research Cognitive Collaborations Complex Credentialing Data Data Collection Data Set Employment Foundations Fright Funding Future Gene Expression Genomics Goals Health Professional Healthcare Imagery Individual Infrastructure Integrative Medicine Intervention Intervention Studies Learning Skill Life Malignant Neoplasms Measures Medical Medicine Mental Depression Meta-Analysis Music Music Therapy Neurologic Outcome Measure Pain Pain intensity Pain interference Pain management Palliative Care Patient Outcomes Assessments Patient advocacy Patients Pharmaceutical Preparations Phenotype Pilot Projects Population Process Productivity Public Health Quality of life Relaxation Research Research Personnel Resources Science Scientific Advances and Accomplishments Scientist Sickle Cell Anemia Therapeutic Training Programs United States Universities University Hospitals advocacy organizations care seeking chronic pain patient clinically relevant cost data de-identification data infrastructure data mining disability functional disability heart rate variability improved institutional capacity instrument interdisciplinary collaboration interest medical schools meetings member metabolomics neuroimaging new technology novel pain reduction practice-based research network social tool

项目摘要

PROJECT SUMMARY/ABSTRACT Pain is a public health problem, a major driver of health care seeking and medication use, a major cause of disability, and a key factor affecting quality of life and productivity. Music-based interventions (MBIs) including music therapy (MT) are known to be effective for managing pain in several populations. However, substantial gaps remain in understanding the mechanisms of action (e.g., cognitive, genomic, metabolomic, and neurologic) by which MBIs influence pain. Barriers to advancing this mechanistic r esearch have included: 1) lack of meaningful and inclusive collaboration between music therapists and mechanistic scientists; 2) inconsistent application and definition of MBIs, patient-reported outcomes, and biological measures; and 3) lack of funding and infrastructure to support interdisciplinary pilot projects. This proposal seeks to establish a NEW collaborative network: Effective Network to advance Scientific Evidence related to Mechanisms of music-Based interventions for pain and support coLlaborative Efforts (ENSEMBLE) to advance collaborative research efforts investigating the mechanisms by which MBIs influence various pain phenotypes. ENSEMBLE will be built on a foundation of well-integrated medical MT practice, strong mechanistic science in integrative health and medicine (IHM), research investigating MT and biological mechanisms of pain in SCD and the BraveNet Practice-Based Research Network. At the outset, SCD will serve as the pain-related condition of interest given the expertise of ENSEMBLE team members at present and strong preliminary data, but other pain conditions will be addressed in future years. ENSEMBLE will be led by investigators from University Hospitals of Cleveland/Case Western Reserve University, University of California Irvine, The Louis Armstrong Center for Music & Medicine, Icahn School of Medicine at Mount Sinai, and Emory University. ENSEMBLE will establish a vibrant collaborative network of music therapists, mechanistic scientists, music intervention researchers, IHM resear chers, and patient-advocacy organizations. The Specific Aims are to: (1) promote meaningful, inclusive, and interdisciplinary collaboration between music therapists, mechanistic scientists, and IHM researchers; (2) develop a comprehensive framework for conducting mechanistic studies in MBIs for pain management; and (3) advance multiple pilot projects investigating novel biological mechanisms of action underlying the effects of MBIs for various pain phenotypes. The IMPACT of ENSEMBLE will be instrumental in 1) promoting meaningful interdisciplinary dialogue; 2) building multi-institutional capacity for initiating MBI research in pain management; 3) generating preliminary data for future R21 or R34 grant proposals; 4) improving data infrastructure; 5) developing future MT clinician researchers; 6) focusing future scientific efforts; and 7) disseminating best practices.

项目概要/摘要疼痛是一个公共卫生问题，是寻求医疗保健和药物使用的主要驱动力，也是导致疼痛的主要原因残疾，也是影响生活质量和生产力的关键因素。基于音乐的干预措施（MBI）包括众所周知，音乐疗法 (MT) 可有效缓解多种人群的疼痛。然而，实质性的在理解作用机制方面仍然存在差距（例如认知、基因组、代谢组学和神经学） MBI 通过这种方式影响疼痛。推进这一机制研究的障碍包括：1）缺乏音乐治疗师和机械科学家之间有意义和包容性的合作； 2）不一致 MBI、患者报告的结果和生物学测量的应用和定义； 3）缺乏资金和支持跨学科试点项目的基础设施。该提案旨在建立一个新的协作网络：促进科学发展的有效网络与基于音乐的疼痛干预机制和支持协作努力相关的证据 (ENSEMBLE) 推进合作研究工作，调查 MBI 影响的机制各种疼痛表型。 ENSEMBLE 将建立在良好集成的医疗 MT 实践的基础上，强大的综合健康与医学 (IHM) 中的机械科学、MT 和生物研究 SCD 的疼痛机制和 BraveNet 基于实践的研究网络。一开始，SCD将服务鉴于 ENSEMBLE 团队成员目前的专业知识和强大的专业知识，作为与疼痛相关的兴趣状况初步数据，但其他疼痛状况将在未来几年得到解决。 ENSEMBLE 将由克利夫兰大学医院/凯斯西储大学的研究人员领导大学、加州大学欧文分校、路易斯阿姆斯特朗音乐与医学中心、伊坎学院西奈山和埃默里大学的医学。 ENSEMBLE 将建立一个充满活力的协作网络音乐治疗师、机械科学家、音乐干预研究人员、IHM 研究人员和患者倡导者组织。具体目标是：（1）促进有意义的、包容性的和跨学科的合作音乐治疗师、机械科学家和 IHM 研究人员； (2) 制定综合框架进行 MBI 疼痛管理的机制研究；（三）推进多项试点研究 MBI 对各种疼痛表型影响的新生物学作用机制。 ENSEMBLE 的影响力将有助于 1) 促进有意义的跨学科对话； 2）建立多机构能力，启动疼痛管理领域的 MBI 研究； 3）生成初步未来 R21 或 R34 拨款提案的数据； 4）改善数据基础设施； 5）培养未来的MT临床医生研究人员； 6）聚焦未来的科学努力； 7) 传播最佳实践。