Translational Multimodal Strategy for Peri-Implant Disease Prevention

种植体周围疾病预防的转化多模式策略

• 批准号: 10736860
• 负责人: Geelsu Hwang
• 金额: $ 52.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10736860
• 关键词: 3-Dimensional; Address; Adhesions; Adhesives; Affect; Age; Alveolar Bone Loss; Anti-Bacterial Agents; Anti-Inflammatory Agents; Apoptosis; Bacterial Adhesion; Bicuspid; Biomechanics; Bite Force; Bone Resorption; Cell Communication; Cell Proliferation; Cell Survival; Cell physiology; Cells; Clinical; Coculture Techniques; Crowns; Data; Dental General Practice; Dental Implants; Dental Plaque; Dental crowns; Development; Disease; Dose; Engineering; Environment; Epithelial Cells; Failure; Fibroblasts; Future; Generations; Gingiva; Goals; Head; Human; Implant; In Situ; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Invaded; Joint Prosthesis; Ligature; Light; Limb Prosthesis; Longevity; Mastication; Measures; Mechanics; Mediating; Microbe; Microbial Biofilms; Modeling; Molar tooth; Motion; Mucositis; Operative Surgical Procedures; Oral; Osseointegration; Outcome; Pathogenesis; Patients; Periodontitis; Phenotype; Phototherapy; Populations at Risk; Production; Property; Protocols documentation; Recording of previous events; Resistance; Risk Reduction; Rupture; Sampling; Secure; Self Assessment; Signal Pathway; Silk; Smoking; Stimulus; Structure; Surface; System; Systemic disease; Testing; Tissues; Titanium; Tooth structure; Toothbrushing; United States; X-Ray Computed Tomography; alveolar bone; antimicrobial; antimicrobial peptide; clinical examination; clinical practice; cytokine; disorder prevention; dosage; efficacy evaluation; efficacy testing; electrical potential; experimental study; healing; human tissue; implantable device; in vivo Model; in vivo evaluation; innovation; keratinocyte; light emission; microCT; microbial; multimodality; next generation; novel; oral pathogen; particle; pathogenic microbe; peri-implantitis; photobiomodulation; porcine model; preservation; prevent; response; restoration; seal; self assembly; senescence; soft tissue; tissue culture

Dental implants have become an important routine component of dental practice with over five million fixtures placed annually in the United States and this number is expected to increase significantly in the future. The peri-implant soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of peri-implant mucositis. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. The goal of this application is to create a novel dental implant construct that renders the implant-supported restoration antibiofilm while providing a tight gingival tissue-implant seal that serves as a barrier to bacterial invasion. This smart dental implant system is a battery-less system that converts biomechanical forces from human oral motions (e.g., chewing or tooth-brushing) into electrical energy and powers light-emitting diodes that enable in situ phototherapy. When used in combination with a long-lasting antibiofilm restorative surface, this self-powered precision phototherapy system circumvents problems with the use of conventional antimicrobials. Ongoing studies indicate that red and near-infrared light is effective in maintaining human gingival tissue cell viability in the face of mono- and multi-microbial challenges. Furthermore, the antibiofilm restorative surface almost completely inhibits bacterial colonization. Based on these exciting supporting data, we hypothesize that force- powering of piezoelectric crystals to produce red and near-infrared light combined with bacterial anti-adhesive restorations creates an anti-inflammatory, pro-healing environment that provides a robust soft-tissue seal and prevents the development of peri-implantitis. We anticipate that the creation of this next-generation anti- inflammatory, antibiofilm dental implant system would increase functionality and provide a new strategy to prevent and control peri-implant diseases, especially in populations at risk, and reduce the risk of implant failure.

种植牙已成为牙科诊所的重要常规组成部分，拥有超过 500 万个固定装置 每年在美国排名第一，预计未来这一数字将大幅增加。这 种植体周围软组织界面在抵抗细菌侵袭、增强 易患随后的种植体周围疾病。种植体周围疾病是影响种植体周围的炎症性疾病 功能性牙种植体周围的软/硬组织。大量实验证据表明 牙菌斑在软组织-种植体界面处积聚以及随后的局部炎症 反应似乎是种植体周围粘膜炎发病机制的关键。此外，在某些个体中， 会发展为种植体周围炎，导致牙槽骨流失和种植失败。该应用程序的目标是 创建一种新型牙种植体结构，使种植体支持的修复体具有抗菌膜，同时 提供紧密的牙龈组织-种植体密封，作为细菌入侵的屏障。这款智能牙科 植入系统是一种无电池系统，可将人类口腔运动（例如， 咀嚼或刷牙）转化为电能并为发光二极管供电，从而实现原位 光疗。当与持久的抗菌膜修复表面结合使用时，这种自供电 精准光疗系统规避了使用传统抗菌药物的问题。进行中 研究表明，红光和近红外光可有效维持人体牙龈组织细胞的活力 面对单一和多种微生物的挑战。此外，抗菌膜修复表面几乎 完全抑制细菌定植。基于这些令人兴奋的支持数据，我们假设强制- 压电晶体供电产生红光和近红外光，并结合细菌抗粘附剂 修复体创造了一个抗炎、促愈合的环境，提供了坚固的软组织密封和 防止种植体周围炎的发展。我们预计这种下一代反 炎症、抗生物膜牙种植体系统将增强功能并提供新的策略 预防和控制种植体周围疾病，特别是高危人群，并降低种植体风险 失败。