Interhemispheric coordination and transfer of visual information

半球间的协调和视觉信息的传递

• 批准号: 10707090
• 负责人: EARL K MILLER
• 金额: $ 38.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707090
• 关键词: Air; Attention; Attention deficit hyperactivity disorder; Back; Behavioral; Bilateral; Binding; Cerebral hemisphere; Cognition; Communication; Conscious; Contracts; Contralateral; Delayed Memory; Disease; Dyslexia; Electrodes; Eye Movements; Feeds; Hemispatial Neglect; Human; Infrastructure; Left; Maintenance; Monkeys; Nature; Parietal; Parietal Lobe; Prefrontal Cortex; Role; Saccades; Schizophrenia; Sensory; Short-Term Memory; Speed; Sports; Stimulus; Stretching; System; Task Performances; Testing; Time; Visual; Visual Cortex; Work; cost; experimental study; gaze; healing; insight; interhemispheric transfer; neural; neurophysiology; neurotransmission; object motion; visual cognition; visual information; visual processing

Abstract It has been a tacit assumption that the “split” of visual sensory processing between right vs left visual hemifields (between the left vs right visual cortex, respectively) is somehow “healed” in higher cortex/ cognition. We now know that is not true, at least not in any straightforward way. Yet visual cognition seems seamless, not split down the middle. We don’t know how it becomes seamless because neurophysiology experiments typically study only one hemisphere at a time. Our project uses bilateral multiple-electrode recordings to test hypotheses about how visual information is coordinated and transferred between cerebral hemispheres. Monkeys will perform tasks in which information is transferred between hemispheres by gaze shifts, by a moving object’s trajectory, or in which information is loaded simultaneously into both hemispheres. Our results will give insights into the neural basis of visual cognition, consciousness, and into cortical communication in general. This is especially relevant for understanding disorders of interhemispheric interaction, such as dyslexia and hemispatial neglect.

抽象的 这是一个默认的假设，即右视觉和左视觉之间视觉感觉处理的“分裂” 半视野（分别位于左视觉皮层和右视觉皮层之间）在较高皮层中以某种方式“治愈”/ 我们现在知道这不是真的，至少不是以任何直接的方式。 无缝，而不是从中间分开，因为神经生理学，我们不知道它是如何变得无缝的。 我们的实验通常一次只研究一个半球。 记录来测试有关视觉信息如何在大脑之间协调和传输的假设 猴子将执行通过凝视在半球之间传递信息的任务。 通过移动物体的轨迹进行移动，或者信息同时加载到两个半球。 我们的研究结果将深入了解视觉认知、意识和皮质的神经基础 这对于理解大脑半球间的疾病尤其重要。 相互作用，例如阅读障碍和半侧空间忽视。