CIRCUIT ANALYSIS OF PFC AND MTL INTERACTIONS IN MONKEYS

猴子 PFC 和 MTL 相互作用的电路分析

• 批准号: 8303573
• 负责人: EARL K MILLER
• 金额: $ 22万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8303573
• 关键词: Address; Animal Model; Animals; Area; Back; Brain; Cognition; Cognitive; Data; Electrodes; Elements; Free Association; Glare; Goals; Human; Instruction; Learning; Left; Link; Location; Maps; Medial; Memory; Memory Disorders; Modeling; Monkeys; Motor; Neurons; Pattern; Play; Positioning Attribute; Prefrontal Cortex; Process; Property; Recording of previous events; Relative (related person); Research; Restaurants; Retrieval; Rodent; Role; Sensory; Short-Term Memory; Signal Transduction; System; Technology; Temporal Lobe; Testing; Time; Training; Visual Fields; Work; abstracting; animal model development; base; experience; insight; memory recall; memory retrieval; neurophysiology; nonhuman primate; relating to nervous system

PROJECT SUMMARY (See instructions): This project addresses the role of functional circuitry of how memories are formed using a non-human primate model. Despite the great deal of evidence that both the prefrontal cortex (PFC) and medial temporal lobe (MTL) are critical for normal memory, there has been remarkably little experimental effort toward understanding how these two systems interact This is, in part, because neurophysiological studies have largely focused on either the PFC or MTL individually. As a result, much of what we know about them is based on comparisons between different animals with different training histories, often on different tasks, and/or different levels of experience. This confounds their comparison and precludes examination of the precise timing of their activity that gives insight into network properties and signal flow. Our goal is a more integrated understanding of the PFC and MTL. We will accomplish this by recording simultaneously from multiple electrodes in multiple subregions of the PFC and MTL while monkeys form and recall new context guided associative memories and while they make inferences based on those memories. By comparing the relative neural latencies for memories to be formed and recalled, we will determine where memories are formed, how they are recalled, and how memory-related signals flow between the PFC and MTL.

项目摘要（参见说明）： 该项目探讨了功能电路在如何使用非人类灵长类动物模型形成记忆方面的作用。尽管有大量证据表明前额叶皮层 (PFC) 和内侧颞叶 (MTL) 对正常记忆至关重要，但在了解这两个系统如何相互作用方面所做的实验努力却非常少，部分原因是神经生理学研究有 主要集中在 PFC 或 MTL 上。因此，我们对它们的了解大部分是基于具有不同训练历史、通常针对不同任务和/或不同经验水平的不同动物之间的比较。这混淆了它们的比较，并妨碍了对其活动的精确时间的检查，从而无法深入了解网络属性和信号流。我们的目标是更 对 PFC 和 MTL 的综合理解。我们将通过同时记录 PFC 和 MTL 多个子区域的多个电极来实现这一目标，同时猴子形成并回忆起新的上下文引导的联想记忆，并根据这些记忆做出推理。通过比较记忆形成和回忆的相对神经潜伏期，我们将确定记忆在哪里形成、如何回忆，以及记忆相关信号如何在 PFC 和 MTL 之间流动。