Emotion processing, gender identity, and differential risk for anxiety and depression in autistic adults

自闭症成人的情绪处理、性别认同以及焦虑和抑郁的差异风险

• 批准号: 10701015
• 负责人: Goldie Ann McQuaid
• 金额: $ 15.84万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701015
• 关键词: Achievement; Address; Adolescent; Adult; Affect; Age; Alexithymias; Amygdaloid structure; Anxiety; Attenuated; Awareness; Behavioral; Brain; Brain imaging; Child; Cognitive; Data Set; Development; Development Plans; Distress; Down-Regulation; Ecological momentary assessment; Emotional; Emotions; Environment; Exhibits; Face; Feeling suicidal; Female; Functional Magnetic Resonance Imaging; Gender; Gender Identity; General Population; Goals; Health; Individual; Influentials; Institution; Intellectual functioning disability; Intervention; Label; Longevity; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mental Depression; Mental Health; Mentors; Mentorship; Methods; Minority; Modeling; Moods; Outcome; Personal Satisfaction; Phenotype; Population; Positioning Attribute; Predictive Factor; Predisposing Factor; Prefrontal Cortex; Prevalence; Protocols documentation; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Scientist; Severities; Shapes; Social Behavior; Stress; Symptoms; Training; Up-Regulation; Woman; adult with autism spectrum disorder; aged; anxiety symptoms; assigned female at birth; autism spectrum disorder; biomarker identification; bodily sensation; career; cisgender; cognitive reappraisal; comorbid depression; completed suicide; depressive symptoms; emotion dysregulation; emotion regulation; emotional experience; expectation; experience; gender diversity; improved; individuals with autism spectrum disorder; male; multidisciplinary; multilevel analysis; neural; open data; phenomenological models; programs; psychiatric comorbidity; severe mental illness; sex; sex assigned at birth; skills; social; social deficits; social expectations; suicidal; trait; young adult

Project Summary/Abstract Research Project Long-Term Objectives: The project will characterize phenotypic & brain factors related to co-occurring depression & anxiety in adults with autism spectrum disorder [ASD] without intellectual disability, with a focus on understudied populations at elevated risk for these conditions: females [ASDf] and gender diverse [ASDgd] individuals. Results will inform biomarker identification for comorbid depression & anxiety in ASD. Overall research design: 3 samples of ASD young adults (aged 18-30y) will be examined. All samples share phenotyping measures; two samples have a common magnetic resonance imaging [MRI] protocol: i) purposively sampled ASDf, ASDgd & ASD males will undergo phenotyping & MRI; ii) ASDf- & ASDgd-enriched sample will undergo phenotyping; iii) existing phenotyping & MRI dataset from a study that oversampled ASDf. Aim 1: Delineate impacts of emotion identification/awareness (alexithymia) & emotion regulation [ER] on depression & anxiety, and roles of sex & a continuous measure of gender identity in these impacts. Methods: multi-level modeling of depressive & anxious symptoms collected via ecological momentary assessment [EMA] will examine alexithymia as a cognitive factor in depression & anxiety, and its association with ER. Aim 2: Delineate brain networks associated with alexithymia & its impacts on depression/anxiety/ER. Methods: regression modeling will relate structural & functional MRI brain connectivity metrics to alexithymia, ER & depression & anxiety. Health Relatedness: ASD adults experience depression & anxiety at elevated rates. Associated with these conditions, ASD adults show alarmingly elevated levels of suicidality. There is no good understanding of why this is, and there is relatively little research on mechanisms—including cognitive and neural factors—that predispose ASD adults to these serious mental health conditions. Candidate’s Career Goals & Development Plan: Dr. McQuaid’s long-term goal is to become an independent investigator with a research program focused on ASD in adulthood and factors relevant to improving mental health in this population. Her short-term goals are to characterize brain & behavioral/cognitive factors that predict increased vulnerability for depression & anxiety among ASDf & ASDgd adults. Building on her multidisciplinary background, Dr. McQuaid will receive training in 1) ASD presentations, gender diversity, & phenomenology & measurement of mood/anxiety in ASD; 2) EMA & computing skills; 3) professional development & open science. Environment: Dr. McQuaid is supported by a cohesive team of expert scientists with overlapping & complementary research programs. They will provide an intensive, focused, & seamless mentorship experience, and their respective expertise & institutional affiliations will provide Dr. McQuaid with the requisite guidance & resources to achieve the research aims & training goals. Taken together, the research & training, mentor team, & environment afforded by the K01 will serve as a bridge that will successfully transition Dr. McQuaid from her current position to that of a fully independent investigator.

项目摘要/摘要 研究项目长期目标：该项目将表征与表型和大脑因素有关 自闭症谱系障碍[ASD]的成人抑郁症和动画无智力障碍， 关注这些条件风险较高的知识人群：女性[ASDF]和性别多样化 [asdgd]个人。结果将为ASD的合并抑郁症和动画提供生物标志物识别。 总体研究设计：将检查3个ASD年轻人（18-30岁）的样本。所有样本共享 表型措施；两个样品具有共同的磁共振成像[MRI]方案：i基本上 采样ASDF，ASDGD和ASD男性将进行表型＆MRI; ii）ASDF-和ASDGD富集样本将 进行表型； iii）从ASDF过采样的研究中，现有的表型和MRI数据集。目标1： 描述情绪识别/意识的影响（alexithymia）和情绪调节[ER]对抑郁症的影响 焦虑和性别的作用和在这些影响中的性别认同的连续衡量。方法：多层 通过生态时刻评估收集的抑郁和焦虑症状的建模[EMA]将检查 Alexithhymia是抑郁症和动画中的认知因素，及其与ER的关联。目标2：描绘大脑 与障碍症及其对抑郁/焦虑/ER的影响相关的网络。方法：回归建模将 将结构和功能性MRI脑连接度指标与Alexithymia，ER和抑郁症和动画相关联。 健康相关性：ASD成年人以升高的速度经历抑郁和动画。与这些相关 条件，ASD成年人表现出震惊的自杀水平。对为什么没有很好的了解 这是，而且对机制（包括认知和神经因素）的研究相对较少，这是 ASD成年人容易患上这些严重的心理健康状况。 候选人的职业目标与发展计划：麦奎德博士的长期目标是成为独立 研究计划的研究人员集中于成年后的ASD，与改善心理有关的因素 这个人群的健康。她的短期目标是表征大脑和行为/认知因素，以预测 ASDF和ASDGD成年人中抑郁症和动画的脆弱性增加。建立在她的多学科 背景，McQuaid博士将接受1）ASD演示，性别多样性和现象学和现象学的培训 ASD中情绪/焦虑的测量； 2）EMA和计算技能； 3）专业发展与开放科学。 环境：McQuaid博士得到了一个有凝聚力的专家科学家团队的支持， 完全研究计划。他们将提供密集，集中和无缝的精神经验， 他们各自的专业知识和机构分支机构将为McQuaid博士提供必要的指导和 实现研究目标和培训目标的资源。综上所述，研究与培训，导师团队， K01提供的环境将成为一座桥梁，将成功从她的 当前位置是完全独立的研究者。