Emotion processing, gender identity, and differential risk for anxiety and depression in autistic adults

自闭症成人的情绪处理、性别认同以及焦虑和抑郁的差异风险

基本信息

批准号：
10590108
负责人：
Goldie Ann McQuaid
金额：
$ 15.89万
依托单位：
GEORGE MASON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-08 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10590108
关键词：
Address Adolescent Adult Affect Age Alexithymias Amygdaloid structure Anxiety Attenuated Awareness Behavioral Birth Brain Brain imaging Child Cognitive Data Set Development Development Plans Down-Regulation Ecological momentary assessment Emotional Emotions Environment Exhibits Face Female Functional Magnetic Resonance Imaging Gender Gender Identity General Population Goals Health Individual Influentials Intellectual functioning disability Intervention Label Longevity Magnetic Resonance Imaging Measurement Measures Mediating Mental Depression Mental Health Mentors Mentorship Methods Minority Modeling Moods Outcome Personal Satisfaction Phenotype Population Positioning Attribute Predictive Factor Predisposing Factor Prefrontal Cortex Prevalence Protocols documentation Psyche structure Research Research Design Research Personnel Research Project Grants Research Training Resources Risk Role Sampling Scientist Severities Shapes Social Behavior Stress Suicide Symptoms Training Up-Regulation Woman adult with autism spectrum disorder aged anxiety symptoms autism spectrum disorder base biomarker identification bodily sensation brain magnetic resonance imaging career cisgender cognitive reappraisal cohesion comorbid depression depressive symptoms emotion dysregulation emotion regulation expectation experience gender diversity improved individuals with autism spectrum disorder male multidisciplinary multilevel analysis open data phenomenological models programs psychiatric comorbidity relating to nervous system severe mental illness sex skills social social deficits social expectations suicidal trait young adult

项目摘要

Project Summary/Abstract Research Project Long-Term Objectives: The project will characterize phenotypic & brain factors related to co-occurring depression & anxiety in adults with autism spectrum disorder [ASD] without intellectual disability, with a focus on understudied populations at elevated risk for these conditions: females [ASDf] and gender diverse [ASDgd] individuals. Results will inform biomarker identification for comorbid depression & anxiety in ASD. Overall research design: 3 samples of ASD young adults (aged 18-30y) will be examined. All samples share phenotyping measures; two samples have a common magnetic resonance imaging [MRI] protocol: i) purposively sampled ASDf, ASDgd & ASD males will undergo phenotyping & MRI; ii) ASDf- & ASDgd-enriched sample will undergo phenotyping; iii) existing phenotyping & MRI dataset from a study that oversampled ASDf. Aim 1: Delineate impacts of emotion identification/awareness (alexithymia) & emotion regulation [ER] on depression & anxiety, and roles of sex & a continuous measure of gender identity in these impacts. Methods: multi-level modeling of depressive & anxious symptoms collected via ecological momentary assessment [EMA] will examine alexithymia as a cognitive factor in depression & anxiety, and its association with ER. Aim 2: Delineate brain networks associated with alexithymia & its impacts on depression/anxiety/ER. Methods: regression modeling will relate structural & functional MRI brain connectivity metrics to alexithymia, ER & depression & anxiety. Health Relatedness: ASD adults experience depression & anxiety at elevated rates. Associated with these conditions, ASD adults show alarmingly elevated levels of suicidality. There is no good understanding of why this is, and there is relatively little research on mechanisms—including cognitive and neural factors—that predispose ASD adults to these serious mental health conditions. Candidate’s Career Goals & Development Plan: Dr. McQuaid’s long-term goal is to become an independent investigator with a research program focused on ASD in adulthood and factors relevant to improving mental health in this population. Her short-term goals are to characterize brain & behavioral/cognitive factors that predict increased vulnerability for depression & anxiety among ASDf & ASDgd adults. Building on her multidisciplinary background, Dr. McQuaid will receive training in 1) ASD presentations, gender diversity, & phenomenology & measurement of mood/anxiety in ASD; 2) EMA & computing skills; 3) professional development & open science. Environment: Dr. McQuaid is supported by a cohesive team of expert scientists with overlapping & complementary research programs. They will provide an intensive, focused, & seamless mentorship experience, and their respective expertise & institutional affiliations will provide Dr. McQuaid with the requisite guidance & resources to achieve the research aims & training goals. Taken together, the research & training, mentor team, & environment afforded by the K01 will serve as a bridge that will successfully transition Dr. McQuaid from her current position to that of a fully independent investigator.

项目概要/摘要研究项目的长期目标：该项目将表征与相关的表型和大脑因素无智力障碍的自闭症谱系障碍 [ASD] 成人同时出现抑郁和焦虑，重点关注以下人群的高风险人群：女性 [ASDf] 和性别多样化 [ASDgd] 个体。结果将为 ASD 共病抑郁和焦虑的生物标志物识别提供信息。总体研究设计：将检查 3 个 ASD 年轻人（18-30 岁）样本，所有样本共享。表型分析测量；两个样本具有共同的磁共振成像 [MRI] 方案： i) 有目的地抽取的 ASDf、ASDgd 和 ASD 男性样本将进行表型分析和 MRI；ii) 富含 ASDf 和 ASDgd 的样本将进行进行表型分析；iii) 来自对 ASDf 进行过采样的研究的现有表型分析和 MRI 数据集：描述情绪识别/意识（述情障碍）和情绪调节 [ER] 对抑郁症和抑郁症的影响焦虑、性别角色以及对这些影响中性别认同的连续衡量方法：多层次。通过生态瞬时评估 [EMA] 收集的抑郁和焦虑症状模型将进行检查述情障碍作为抑郁和焦虑的认知因素及其与 ER 的关系目标 2：描绘大脑。与述情障碍相关的网络及其对抑郁/焦虑/ER 的影响方法：回归模型将。与述情障碍、ER、抑郁和焦虑相关的结构和功能 MRI 大脑连接指标。健康相关性：自闭症谱系障碍成年人经历抑郁和焦虑的几率较高。在这种情况下，自闭症谱系障碍成年人的自杀倾向高得惊人，目前尚不清楚其中的原因。确实如此，而且对包括神经因素在内的机制的研究相对较少。使自闭症谱系障碍成年人容易出现这些严重的心理健康问题。候选人的职业目标和发展计划：麦克奎德博士的长期目标是成为一名独立的人研究员，其研究项目专注于成年自闭症谱系障碍以及与改善心理健康相关的因素她的短期目标是描述预测该人群的大脑和行为/认知因素。在她的多学科基础上，ASDf 和 ASDgd 成年人更容易患抑郁症和焦虑症。背景，麦克奎德博士将接受以下方面的培训：1) 自闭症谱系障碍演讲、性别多样性和现象学自闭症谱系障碍 (ASD) 情绪/焦虑的测量；2) EMA 和计算技能；3) 专业发展和开放科学。环境：麦克奎德博士得到了一个由专家科学家组成的有凝聚力的团队的支持，他们的重叠和他们将提供密集、专注和无缝的指导经验，他们各自的专业知识和机构隶属关系将为麦克奎德博士提供必要的指导和实现研究目标和培训目标的资源，研究和培训、导师团队、 K01 提供的环境将成为一座桥梁，成功地将 McQuaid 博士从她身边过渡到目前的职位是完全独立的调查员。