Asian American Community Cohort and Equity Study (ACCESS)

亚裔美国人社区队列和公平研究 (ACCESS)

• 批准号: 10724846
• 负责人: Carolyn Y. Fang
• 金额: $ 62.66万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724846
• 关键词: Address; Age; American; Asian; Asian Americans; Asian population; Behavioral; Biological; Biological Markers; Biomedical Research; Black Populations; Blood; Cambodian; Cardiometabolic Disease; Cardiovascular Diseases; Chinese; Chronic Disease; Cities; Clinic; Clinical; Cohort Studies; Collaborations; Collection; Communities; Complex; Data; Data Aggregation; Data Collection; Data Reporting; Diabetes Mellitus; Dietary Assessment; Dietary intake; Disparity; Enrollment; Epidemiology; Equity; Ethnic Origin; Filipino; Food; Goals; Growth; Hair; Health; Health Policy; Health behavior; High Prevalence; Hispanic Populations; Hypertension; Image; Incidence; Individual; Infrastructure; Intervention; Investigation; Koreans; Language; Longitudinal cohort study; Low Prevalence; Mediating; Methods; Mid-Atlantic Region; Minority; Modeling; Modification; Morbidity - disease rate; Nail plate; National Heart, Lung, and Blood Institute; Native Hawaiian or Other Pacific Islander; Nature; Neighborhoods; New Jersey; New York City; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Parents; Participant; Pathway interactions; Patient Recruitments; Phase; Philadelphia; Pilot Projects; Population; Population Heterogeneity; Prevalence; Prevention Guidelines; Procedures; Productivity; Protocols documentation; Provider; Public Health Practice; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Sampling Studies; Secure; Standardization; Strategic vision; Structure of nail of toe; Subgroup; Urine; Vietnamese; Vulnerable Populations; Woman; Work; cardiometabolism; clinical examination; cohort; community organizations; community partnership; data repository; digital tool; disorder risk; experience; health difference; high risk; improved; lifestyle factors; member; men; mobile application; mortality; multidisciplinary; novel; outreach; participant retention; programs; prospective; psychosocial; racial population; recruit; retention rate; screening guidelines; social culture; social health determinants; socioeconomics; standardize measure

PROJECT SUMMARY Between 2000 and 2020, Asian Americans were the fastest growing racial group in the US, increasing from 10.5 million to 24 million individuals. By 2060, the number of US Asians is projected to rise to 46 million, more than triple their 2000 population. Although Asian Americans (AAs) are commonly viewed as a 'model minority' based on socioeconomic and health indicators, AAs actually have chronic disease rates that converge with or exceed those of US whites and are at higher risk for several cardiometabolic disorders despite having lower rates of obesity. However, due to limited data and the common practice of reporting aggregated data across multiple AA subgroups, the true extent and nature of the disparities that exist is not well understood. Thus, to address important gaps in the field, we propose to establish the Asian American Community Cohort and Equity Study (ACCESS) spanning across the greater Philadelphia-New Jersey-New York City region, which will include 2,400 men and women ages 25-64 drawn from 3 US Asian subgroups: Chinese (n=800), Vietnamese (n=800), and Filipino (n=800). Our multidisciplinary team will leverage our 22-year established PA-NJ-NYC Regional Network of collaborative community-based organization partners, clinical providers, city health departments, and academic investigators to support the cohort’s infrastructure and the recruitment of diverse research participants with respect to nativity, language, and generational status. With collaboration from our esteemed Community Advisory Board and Scientific Advisory Board members, our team has a strong and successful record of scientific productivity and expertise in: 1) the conduct of community-engaged longitudinal cohort studies with AA populations; 2) rigorous assessment of dietary intake and other health behaviors and lifestyle factors; 3) standardized measures of social determinants of health (SDoH) and neighborhood-level exposures; 4) collection of high-quality biospecimens for analysis of biologic markers; and 5) assessment of cardiometabolic outcomes (e.g., hypertension, type 2 diabetes, cardiovascular disease). The overall objectives of this application are to establish a rigorous infrastructure of ACCESS including formalizing clinical/community partnerships, developing cohort infrastructure, and establishing study protocols to support the standardized collection of comprehensive psychosocial, behavioral, and neighborhood-level data, along with biospecimens and other clinical exams. The proposed activities are closely aligned with NHLBI’s Strategic Vision and will address key research questions regarding how the prevalence of cardiometabolic disorders varies across Asian ethnic subpopulations, how SDoH relates to disease risk in specific subpopulations, and the identification of behavioral and biologic pathways that may account for individual or group differences in disease risk. This synergistic multidisciplinary plan to establish a prospective comprehensive cohort that includes 3 large AA subgroups will yield a rich resource to support rigorous research on multi-level pathways contributing to cardiometabolic disease risk and health outcomes in these large and growing, but understudied populations that experience significant disparities.

项目概要 2000 年至 2020 年间，亚裔美国人是美国增长最快的种族群体，从 10.5 到 2060 年，美国亚裔人数预计将增加到 4600 万，超过 尽管亚裔美国人 (AA) 通常被视为“模范少数族裔”，但人口数量却是 2000 年的三倍。 在社会经济和健康指标上，AA的慢性病发病率实际上接近或超过 尽管美国白人的心血管代谢疾病发病率较低，但他们患多种心脏代谢疾病的风险较高 然而，由于数据有限以及报告多个 AA 的汇总数据的常见做法。 亚群体中存在的差异的真实程度和性质尚不清楚，因此尚不清楚如何解决。 该领域的重要空白，我们建议建立亚裔美国人社区队列和公平研究 (ACCESS) 跨越大费城-新泽西-纽约市地区，其中将包括 2,400 年龄 25-64 岁的男性和女性来自 3 个美国亚裔群体：中国人 (n=800)、越南人 (n=800) 和 菲律宾人 (n=800)。我们的多学科团队将利用我们 22 年建立的宾夕法尼亚州-新泽西州-纽约市区域网络。 社区合作组织合作伙伴、临床提供者、城市卫生部门以及 学术研究人员支持队列的基础设施和招募不同的研究参与者 与我们尊敬的社区的合作有关出生、语言和代际地位。 顾问委员会和科学顾问委员会成员，我们的团队在科学领域拥有强大而成功的记录 生产力和专业知识：1）与 AA 进行社区参与的纵向队列研究 人群；2）严格评估饮食摄入量和其他健康行为和生活方式因素； 健康社会决定因素 (SDoH) 和社区层面暴露的标准化测量；4) 收集； 用于分析生物标志物的高质量生物样本；以及 5) 评估心脏代谢结果 （例如高血压、2 型糖尿病、心血管疾病）。 建立严格的 ACCESS 基础设施，包括正规化临床/社区伙伴关系、开发 基础设施队列，并建立研究方案以支持全面的标准化收集 心理社会、行为和邻里层面的数据，以及生物样本和其他临床检查。 拟议的活动与 NHLBI 的战略愿景密切相关，并将解决关键研究问题 关于亚洲种族亚人群心脏代谢疾病的患病率有何差异， SDoH 与特定亚群的疾病风险以及行为和生物特征的识别相关 可能解释疾病风险的个体或群体差异的途径。 计划建立一个包括3大AA亚组的前瞻性综合队列，将产生丰富的资源 支持对心脏代谢疾病风险和健康的多层次贡献途径的严格研究 这些巨大且不断增长但未得到充分研究的人群的结果存在显着差异。