Vermont Genetics Network - Vermont INBRE

佛蒙特州遗传学网络 - 佛蒙特州 INBRE

• 批准号: 10657461
• 负责人: CHRISTOPHER S FRANCKLYN
• 金额: $ 382.03万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657461
• 关键词: Advisory Committees; Applied Research; Award; Basic Science; Behavior; Bioinformatics; Biomedical Research; Career Choice; Categories; Centers of Research Excellence; Collaborations; Communication; Core Facility; Data Analyses; Development; Education; Educational Curriculum; Enrollment; Evaluation; Extramural Activities; Faculty; First Generation College Students; Fostering; Funding; Genetic; Goals; Grant; Grant Review; Health; Healthcare; Human; Human Resources; Institution; Internships; Leadership; Mentors; Mission; Network Infrastructure; Population; Process; Productivity; Program Research Project Grants; Proteomics; Protocols documentation; Publications; Publishing; Research; Research Infrastructure; Research Training; Resource Sharing; Resources; Rural; STEM field; Services; Students; Universities; Vermont; Woman; Work; career; college; community college; course module; cyber infrastructure; data management; experience; faculty research; innovation; meetings; member; organizational structure; outreach; programs; science education; student training; success; symposium; tool; undergraduate education; undergraduate research; undergraduate research experience; undergraduate student

Project Summary The Mission of the Vermont Genetics Network (VGN) is to build the biomedical research infrastructure in Vermont. Our focus is on human health and behavior as broadly defined. The goal is to build and sustain a culture of research throughout the State of Vermont by facilitating the research capacity of faculty members and the education of undergraduates at our baccalaureate partner institutions. We have created state-of-the-art facilities at the University of Vermont (UVM), the lead institution, to serve the network; promoted faculty and student research at VGN Baccalaureate Partner Institutions (BPIs) with research awards and mentoring; and provided BPIs and other colleges with internship experiences and class modules for students to have hands-on experience with research protocols and use VGN’s facilities. Assessments show that VGN-funded faculty at BPIs and UVM are publishing and becoming competitive. Our efforts in the first 3 ½ years of INBRE 3 have resulted in 114 publications (BPI faculty = 31; Bioinformatics = 21; Proteomics = 50; Microarray = 12), 67 extramural grants (past and current BPI faculty funded in INBRE 3 = 21; Bioinformatics = 8; Proteomics = 38) funded to VGN faculty or facilitated by VGN, and 146 students serving as interns in the STEM fields with 89% of those tracked working in or pursuing graduate work in a STEM field. Our efforts promote a culture of research and provide the facilities to promote faculty research and student training. Four new specific aims in INBRE 4 build upon successes and bring innovation to VGN: 1. Enhance advising of faculty to facilitate grants and articles funded/accepted for publications; 2. Build interdisciplinary thematic groups of faculty scholars to encourage collaboration and enhance the quality of research inquiries; 3. Enhance educational experiences and continue diversification of undergraduates; and 4. Continue to enhance sharing of research resources through our Bioinformatics Core, Proteomics Core, Core Marketplace, and collaboration with other INBREs and UVM COBREs. The Professional Development and Education Core will implement Aims 1, 2, and 3. The Bioinformatics Core will implement Aim 4 (as well as Aims 1 and 3) by providing critical data analysis support for the VGN facilities; giving assistance to network faculty for research and incorporation of research into classes; and supporting cyber infrastructure for network communication and data management. The Proteomics Facility will implement Aim 4 (as well as Aims 1 and 3) by conducting proteomic analyses (our Facility is the only full service one in Vermont, facilitating publication of findings, and providing educational opportunities for students. The Administrative Core will provide logistical, financial, compliance oversight, and external evaluation to ensure that VGN is sensitive to changing needs and evolving strengths of the network institutions. The Administrative Core arranges mentoring and undergraduate intern programs to increase the biomedical workforce size and diversity through the PDE Core. Our focus on Human Health and Behavior allows for greater participation at BPIs than our earlier focus on genetics. VGN has strong support and commitments from all network institutions and collaborations among regional INBREs and COBREs.

项目摘要 佛蒙特州遗传网络（VGN）的使命是在佛蒙特州建立生物医学研究基础设施。 我们的重点是广泛定义的人类健康和行为。目标是建立和维持研究文化 在整个佛蒙特州，通过促进教职员工的研究能力和教育 我们的学士学位机构的本科生。 我们已经在佛蒙特大学（UVM）的领导机构创建了最先进的设施，以服务 网络;通过研究奖的VGN学士学位合作机构（BPI）促进教师和学生研究 和心理；并为BPI和其他大学提供了实习经验和班级模块，以供学生 研究协议的实践经验并使用VGN的设施。评估表明，VGN资助的教师 BPI和UVM正在出版并变得更有竞争力。我们在Inbre 3的前3½年中的努力已导致 114个出版物（BPI教师= 31; Bioinformatics = 21;蛋白质组学= 50; MicroArray = 12），67个壁外赠款（过去 以及目前以Inbre 3 = 21资助的BPI教师；生物信息学= 8;蛋白质组学= 38）资助为VGN教师或促进 由VGN和146名在STEM领域的实习生的学生，其中89％的追踪或追求的学生 在STEM领域的研究生工作。我们的努力促进了一种研究文化，并提供了促进教师的设施 研究和学生培训。 Inbre 4的四个新特定目标以成功为基础，并为VGN带来创新：1。增强教师的咨询 促进资助/接受出版的赠款和文章； 2。建立跨学科主题群体 鼓励合作并提高研究询问质量的学者； 3。增强教育经验 并继续多样化的本科生； 4。继续通过我们的 生物信息学核心，蛋白质组学核心，核心市场以及与其他INBRES和UVM COBRES的合作。这 专业发展和教育核心将实施目标1、2和3。生物信息学核心将实施 AIM 4（以及目标1和3）通过为VGN设施提供关键的数据分析支持；提供帮助 研究和基础设施研究课程的网络教师；并支持网络网络基础架构 通信和数据管理。蛋白质组学设施将实施目标4（以及目标1和3） 进行蛋白质组学分析（我们的设施是佛蒙特州唯一的全面服务，支持发现发现， 并为学生提供教育机会。行政核心将提供后勤，财务， 合规性监督和外部评估，以确保VGN对不断变化的需求和不断发展的优势敏感 网络机构。行政核心安排心理和本科实习计划 通过PDE核心增加生物医学劳动力的大小和多样性。我们关注人类健康和行为 比我们早期对遗传学的关注允许在BPI中更多的参与。 VGN有强烈的支持和承诺 来自所有网络机构以及区域构成和共同点之间的合作。

项目成果

Analysis of the Interactome of the Toxoplasma gondii Tgj1 HSP40 Chaperone.

• DOI: 10.3390/proteomes11010009
• 发表时间: 2023-03-01
• 期刊: Proteomes
• 影响因子: 3.3
• 作者: Munera López J;Alonso AM;Figueras MJ;Saldarriaga Cartagena AM;Hortua Triana MA;Diambra L;Vanagas L;Deng B;Moreno SNJ;Angel SO
• 通讯作者: Angel SO

Synthesis and structural data of tetrabenzo[8]circulene.

• DOI: 10.1002/chem.201304657
• 发表时间: 2014-03-24
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Miller, Robert W.;Duncan, Alexandra K.;Schneebeli, Severin T.;Gray, Danielle L.;Whalley, Adam C.
• 通讯作者: Whalley, Adam C.

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail.

• DOI: 10.1128/mbio.00754-16
• 发表时间: 2016-09-13
• 期刊: mBio
• 影响因子: 6.4
• 作者: Krishnamurthy S;Deng B;Del Rio R;Buchholz KR;Treeck M;Urban S;Boothroyd J;Lam YW;Ward GE
• 通讯作者: Ward GE

Identification of new palmitoylated proteins in Toxoplasma gondii.

• DOI: 10.1016/j.bbapap.2016.01.010
• 发表时间: 2016-04
• 期刊: Biochimica et biophysica acta
• 作者: Caballero MC;Alonso AM;Deng B;Attias M;de Souza W;Corvi MM
• 通讯作者: Corvi MM

Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes.

• DOI: 10.3389/fonc.2020.584683
• 发表时间: 2020
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Fairfield H;Costa S;Falank C;Farrell M;Murphy CS;D'Amico A;Driscoll H;Reagan MR
• 通讯作者: Reagan MR