Using mobile technology to prevent HIV and related Youth Health problems: Sexual health, Mental health, and Substance use in southwest Uganda (Youth Health SMS)

使用移动技术预防​​艾滋病毒和相关的青少年健康问题：乌干达西南部的性健康、心理健康和药物使用（青少年健康短信）

• 批准号: 10656457
• 负责人: Philip Kreniske
• 金额: $ 17.81万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656457
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent and Young Adult; Adult; Affect; Alcohol consumption; Area; Behavior; Biological Factors; Caring; Cellular Phone; Cohort Studies; Communication; Communities; Continuity of Patient Care; Counseling; Country; Cross-Sectional Studies; Data; Data Analyses; Decision Making; Development; Epidemic; Epidemiology; Evidence based intervention; Face; Funding; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; HIV Seroprevalence; HIV risk; HIV/STD; Health; Health Professional; Healthcare; Household; Human immunodeficiency virus test; Incidence; Income; International; Intervention; Intervention Trial; Life; Manuscripts; Mediating; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentorship; Ownership; Population; Positioning Attribute; Prevention; Prevention strategy; Professional counselor; Proliferating; Psychologist; Randomized, Controlled Trials; Recommendation; Reproductive Health; Research; Research Activity; Research Personnel; Research Priority; Research Project Grants; Resources; Risk; Risk Behaviors; Risk Factors; STI prevention; Safe Sex; Schools; Services; Sex Behavior; Sexual Health; Site; Socialization; Southern Africa; Substance abuse problem; Symptoms; Technology; Testing; Training; Uganda; United States National Institutes of Health; Universities; Work; Writing; Youth; acceptability and feasibility; alcohol screening; behavioral and social science; behavioral health; career; comorbidity; design; digital; digital technology; evidence base; experience; girls; hands on research; health disparity; high risk; implementation science; improved; innovation; longitudinal analysis; low and middle-income countries; meetings; mobile computing; mobile phone based intervention; panacea; pre-exposure prophylaxis; prevent; programs; protective factors; screening; secondary analysis; sexual relationship; sexual risk behavior; skills; social; social culture; social factors; substance use; systematic review; therapy design; uptake; young woman

The proposed K01 Award will provide the candidate, Dr. Kreniske, with the skills to achieve his long-term goal of being an independent HIV investigator and an international leader who leverages digital technology to improve adolescent and young adult (AYA) uptake of HIV prevention (including PrEP and HIV testing) and linkage to behavioral health care. The candidate is a developmental psychologist with experience in qualitative and cross- sectional research, domestically and internationally. The proposed training and research experience will expand the candidate’s ability to design and evaluate interventions for AYA at high risk for HIV infection and address the high priority topic of the National Institute of Health (NIH) Office of AIDS Research (OAR) of reducing the incidence of HIV. To achieve his overall goals, Dr. Kreniske will receive additional training in: (1) longitudinal data analysis for the purposes of interpreting associations between mobile phone use and protective and risk factors for HIV infection in under-resourced settings; (2) adapting mobile phone-based interventions to address multiple HIV risk factors as they relate to HIV prevention and the HIV care cascade; (3) evaluating mobile phone- based interventions for AYA in under-resourced settings using randomized controlled trials (RCT); and (4) professional skills for a successful independent research career, including grant and manuscript writing. The candidate has assembled a mentorship team of national and international leaders who will support his successful transition to independence through coursework, directed readings, one-on-one meetings, hands-on research activities, and completion of an independent research project. Dr. Kreniske’s work is based in East and Southern Africa (ESA) where AYA have the highest rates of HIV infection worldwide. Mental health and substance use affect decision making about sexual and reproductive health and thus function as critical barriers to prevention of HIV infection. AYA, particularly in this socio-cultural context, face unique challenges in accessing counselors who can provide mental health and substance use assessment and treatment. To address these challenges the candidate will identify how technology is related to known HIV risk factors (e.g. sexual behaviors, mental health symptoms, substance use) and adapt and evaluate a mobile phone-based intervention. This will serve as proof of concept for an R01 proposal to evaluate a scalable mobile phone-based intervention to reduce HIV infection by targeting at risk AYA. Research and training will occur at NYSPI/ Columbia University as well as international sites, in affiliation with two NIH-funded studies, (1) SSTAR, a study of AYA social transitions and determinants (R01HD091003; PI Santelli), which will provide secondary data from the Rakai Community Cohort Study (RCCS), and (2) SUUBI4Her (R01MH113486; PI Ssewamala), an HIV prevention study for AYA girls in Uganda that will provide secondary data on mental health. Research findings and skills obtained during the K01 will position Dr. Kreniske to become an independent investigator who can contribute to the efforts to end the HIV epidemic through innovative interventions tailored to at risk AYA.

拟议的K01奖将为候选人Kreniske博士提供实现长期目标的技能 成为遗传者的独立艾滋病毒和国际领导者，他们利用数字技术改进 青少年和年轻人（aya）对HIV预防（包括PREP和HIV测试）的吸收，并与 行为医疗保健。 分区研究，国内和国际培训经验将扩大 候选人设计和评估对HIV感染高风险AYA的设计和评估干预措施的能力 美国国家卫生研究院（NIH）艾滋病研究（NIH）的高优先级主题减少了您 艾滋病毒的发病率。 数据分析是为了解释手机使用使用保护和风险的解释的目的 资源不足的环境中艾滋病毒感染的因素； 多种艾滋病毒风险因素与HIB预防和HIB护理级联有关；（3）评估手机 - 使用随机对照试验（RCT）和（4）基于资源不足的设置中的AYA干预措施； 成功的独立研究职业的专业技能，包括赠款和手稿 候选人哈斯组建了一个由国家国际领导人组成的导师团队，他们将支持他的成功 通过课程，定向阅读，一对一的会议，动手研究过渡到无限制 活动以及一个独立研究项目的压缩。 非洲（ESA）AYA在全球HIB感染率最高。 影响有关性健康和生殖健康的决策，因此FUS是生产的关键障碍 艾滋病毒感染。 谁可以提供心理健康和物质使用评估和治疗。 候选人将确定技术与已知的HIV风险因素（例如性行为，心理健康 症状，使用物质）并调整和评估基于手机的干预措施。 R01提案评估可扩展手机的干预措施以减少Hive感染的概念 通过面向风险的aya。 （1）SSTAR的两项研究，对AYA社会过渡和决定性的研究 （R01HD091003; Pi Santelli），该数据将提供Rakai社区队列研究的辅助数据 （RCC）和（2）Suubi4her（R01MH113486; Pi Ssewamala），乌干达Aya Girls的HIV生产研究 这将提供有关心理健康的次要数据。 Kreniske博士的职位成为一名独立的独立研究者，可以为艾滋病毒做出贡献 通过针对处于风险的危险的创新干预措施进行的流行病。