Using mobile technology to prevent HIV and related Youth Health problems: Sexual health, Mental health, and Substance use in southwest Uganda (Youth Health SMS)

使用移动技术预防​​艾滋病毒和相关的青少年健康问题：乌干达西南部的性健康、心理健康和药物使用（青少年健康短信）

• 批准号: 10192841
• 负责人: Philip Kreniske
• 金额: $ 18.1万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192841
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent and Young Adult; Adult; Affect; Alcohol consumption; Area; Behavior; Biological Factors; Car Phone; Caring; Cohort Studies; Communities; Continuity of Patient Care; Country; Cross-Sectional Studies; Data; Data Analyses; Decision Making; Development; Epidemic; Epidemiology; Evidence based intervention; Face; Funding; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; HIV Seroprevalence; HIV risk; HIV/STD; Health; Health Professional; Healthcare; Household; Human immunodeficiency virus test; Incidence; Income; Information Services; International; Intervention; Intervention Trial; Life; Manuscripts; Mediating; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentorship; Ownership; Play; Population; Positioning Attribute; Prevention; Prevention strategy; Professional counselor; Psychologist; Randomized Controlled Trials; Reading; Reproductive Health; Research; Research Activity; Research Personnel; Research Priority; Research Project Grants; Research Training; Resources; Risk; Risk Behaviors; Risk Factors; Role; STI prevention; Safe Sex; Schools; Sex Behavior; Sexual Health; Site; Socialization; Southern Africa; Substance abuse problem; Symptoms; Technology; Testing; Training; Uganda; United States National Institutes of Health; Universities; Work; Writing; Youth; acceptability and feasibility; alcohol screening; base; behavioral health; behavioral/social science; career; comorbidity; design; digital; evidence base; experience; girls; hands on research; health disparity; high risk; implementation science; improved; innovation; longitudinal analysis; low and middle-income countries; meetings; mental health counseling; mobile computing; panacea; pre-exposure prophylaxis; prevent; programs; protective factors; screening; secondary analysis; sexual relationship; sexual risk behavior; skills; social; social culture; social factors; substance use; systematic review; therapy design; uptake; young woman

The proposed K01 Award will provide the candidate, Dr. Kreniske, with the skills to achieve his long-term goal of being an independent HIV investigator and an international leader who leverages digital technology to improve adolescent and young adult (AYA) uptake of HIV prevention (including PrEP and HIV testing) and linkage to behavioral health care. The candidate is a developmental psychologist with experience in qualitative and cross- sectional research, domestically and internationally. The proposed training and research experience will expand the candidate’s ability to design and evaluate interventions for AYA at high risk for HIV infection and address the high priority topic of the National Institute of Health (NIH) Office of AIDS Research (OAR) of reducing the incidence of HIV. To achieve his overall goals, Dr. Kreniske will receive additional training in: (1) longitudinal data analysis for the purposes of interpreting associations between mobile phone use and protective and risk factors for HIV infection in under-resourced settings; (2) adapting mobile phone-based interventions to address multiple HIV risk factors as they relate to HIV prevention and the HIV care cascade; (3) evaluating mobile phone- based interventions for AYA in under-resourced settings using randomized controlled trials (RCT); and (4) professional skills for a successful independent research career, including grant and manuscript writing. The candidate has assembled a mentorship team of national and international leaders who will support his successful transition to independence through coursework, directed readings, one-on-one meetings, hands-on research activities, and completion of an independent research project. Dr. Kreniske’s work is based in East and Southern Africa (ESA) where AYA have the highest rates of HIV infection worldwide. Mental health and substance use affect decision making about sexual and reproductive health and thus function as critical barriers to prevention of HIV infection. AYA, particularly in this socio-cultural context, face unique challenges in accessing counselors who can provide mental health and substance use assessment and treatment. To address these challenges the candidate will identify how technology is related to known HIV risk factors (e.g. sexual behaviors, mental health symptoms, substance use) and adapt and evaluate a mobile phone-based intervention. This will serve as proof of concept for an R01 proposal to evaluate a scalable mobile phone-based intervention to reduce HIV infection by targeting at risk AYA. Research and training will occur at NYSPI/ Columbia University as well as international sites, in affiliation with two NIH-funded studies, (1) SSTAR, a study of AYA social transitions and determinants (R01HD091003; PI Santelli), which will provide secondary data from the Rakai Community Cohort Study (RCCS), and (2) SUUBI4Her (R01MH113486; PI Ssewamala), an HIV prevention study for AYA girls in Uganda that will provide secondary data on mental health. Research findings and skills obtained during the K01 will position Dr. Kreniske to become an independent investigator who can contribute to the efforts to end the HIV epidemic through innovative interventions tailored to at risk AYA.

拟议的K01奖将为候选人Kreniske博士提供实现长期目标的技能 成为独立的艾滋病毒调查员和国际领导者，他利用数字技术改进 青少年和年轻人（AYA）预防HIV的吸收（包括PREP和HIV测试），并与 行为保健。候选人是一位具有定性和跨性能经验的发展心理学家 分区研究，国内和国际。拟议的培训和研究经验将扩大 候选人设计和评估对HIV感染高风险AYA的干预措施的能力，并解决 国家卫生研究院（NIH）艾滋病研究（OAR）的高优先级主题 艾滋病毒的发病率。为了实现他的总体目标，Kreniske博士将在以下方面接受额外的培训：（1）纵向 数据分析是为了解释手机使用与保护和风险之间的关联 资源不足的环境中艾滋病毒感染的因素； （2）调整基于手机的干预措施来解决 与艾滋病毒预防和艾滋病毒护理级联有关的多种艾滋病毒危险因素； （3）评估手机 - 使用随机对照试验（RCT）在资源不足的设置中基于AYA的干预措施； （4） 成功独立研究职业的专业技能，包括赠款和手稿写作。这 候选人组建了一个由国家和国际领导人组成的心态团队，他们将支持他的成功 通过课程，定向阅读，一对一的会议，动手研究过渡到独立性 活动，并完成一个独立的研究项目。 Kreniske博士的工作位于东和南部 非洲（ESA）AYA在世界范围内拥有最高的HIV感染率。心理健康和药物使用 影响有关性健康和生殖健康的决策，从而充当预防的关键障碍 艾滋病毒感染。 AYA，尤其是在这种社会文化背景下，在访问案件时面临独特的挑战 谁可以提供心理健康和药物使用评估和治疗。解决这些挑战 候选人将确定技术与已知的HIV风险因素（例如性行为，心理健康 症状，使用物质）并调整和评估基于手机的干预措施。这将作为证明 R01建议评估可扩展手机的干预措施以减少HIV感染的概念 通过面向风险aya。研究和培训将在NYSPI/哥伦比亚大学以及国际 （1）SSTAR，对AYA社会过渡和决定者的研究 （R01HD091003; Pi Santelli），该数据将提供Rakai社区队列研究的辅助数据 （RCC）和（2）Suubi4her（R01MH113486; Pi Ssefamala），乌干达Aya Girls的HIV预防研究 这将提供有关心理健康的次要数据。 K01期间获得的研究结果和技能将 Kreniske博士的职位成为一名独立调查员，他可以为结束艾滋病毒的努力做出贡献 通过针对处于风险的危险的创新干预措施进行的流行病。