Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

社区参与的针对服务不足和/或弱势群体的 COVID-19 检测研究

基本信息

批准号：
10662839
负责人：
Marianna K Baum
金额：
$ 99.13万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10662839
关键词：
Adult African American population Alcohols Animal Experiments Animals Area Behavioral Biological Markers Biological Specimen Banks Biological Specimen database COVID-19 testing Cause of Death Cessation of life Cirrhosis Clinical Cocaine Cocaine Abuse Cocaine Users Data Databases Diagnostic Equipment Disease Disease Outcome Drug abuse Etiology FDA approved Florida Funding Future Genetic Markers Goals HIV HIV Infections HIV/HCV Health Health Services Accessibility Hepatitis C Hepatitis C Therapy Hepatitis C co-infection Hepatitis C virus Heterosexuals Hispanic Hispanic Populations Human Immunity Immunosuppression In Vitro Intervention Laboratories Liver Fibrosis Liver diseases Magnetic Resonance Elastography Malnutrition Metabolic Morbidity - disease rate Nature Outcome Oxidative Stress Participant Pathogenesis Pattern Persons Pharmaceutical Preparations Pharmacotherapy Population Populations at Risk Primary carcinoma of the liver cells Prognostic Factor Program Development Program Evaluation Quality of life Recording of previous events Research Research Design Resources Risk Factors Role Signal Transduction Stimulus Substance abuse problem Treatment Failure Underserved Population United States United States National Institutes of Health Virus Diseases Vulnerable Populations Woman antifibrotic treatment antiretroviral therapy chronic liver disease co-infection cocaine use cohort community engaged research comorbidity cytokine data harmonization drug of abuse effective intervention effective therapy evidence base fibrogenesis follow-up health care availability health disparity health disparity populations improved insight interest liver development mortality noninvasive diagnosis novel prevent programs prospective recruit retention rate sociodemographics time interval transmission process treatment effect uptake

项目摘要

ABSTRACT Liver disease is a major cause of death in HIV infected persons in the United States. While advances in antiretroviral therapy have significantly reduced HIV-related mortality, co-infection with hepatitis C virus (HCV), is widespread and accelerates progression of liver fibrosis to cirrhosis and liver carcinoma. In addition, substance abuse accelerates HIV disease, and may facilitate progression of liver fibrosis. The primary goal of this proposal is to continue to follow the existing Miami Adult Studies on HIV (MASH) cohort, its specimen repository and database, and expand it from the current 881 to 1,500 study participants. The purpose is to generate collaborative studies to investigate the impact of cocaine, by far the most prevalent drug of abuse in South Florida, on HIV infection, HIV/HCV co-infection, and on long-term morbidity with a focus on liver disease in this population with disparities in access to care. HIV and HCV un-infected cocaine users and non-users will also be recruited to allow determination of the impact of cocaine use alone, as well as the interaction of cocaine use with HIV, HCV, and HIV/HCV co-infection. As new and more effective treatments and access to care for HIV, HCV and drug abuse become available, maintaining a well- characterized cohort, specimen repository and database will create a strong resource platform for current and future collaborative research. Observing the uptake of new HCV treatments and potential new cocaine cessation programs in this at-risk population with health disparities will provide data on barriers and facilitators to effective treatments to prevent long-term morbidity and mortality. We have followed the MASH cohort of 881 participants for up to 12 years with excellent retention rates, and have created a specimen repository and a database. The MASH cohort in Miami is unique because it will be a mostly Hispanic cohort with a large number of African Americans, women, non-injector drug users, with predominantly heterosexual HIV- transmission etiology. We propose to (1) compare the progression of liver fibrosis over four years among cocaine users and non-users in HIV+/HCV-, HIV+/HCV+, HIV-/HCV+, and HIV-/HCV-, using a novel non- invasive diagnostic device, the Magnetic Resonance Elastography (MRE). We also propose to (2) compare the pattern over four years of biomarkers and identify genetic markers associated with the mechanisms of liver fibrosis among cocaine users and non-users. Understanding the role of cocaine use in the context of HIV and HIV/HCV co-infections and lack of lasting effects of treatments for cocaine use cessation are crucial in order to gain insights into the pathogenesis and disease outcomes, and to provide the basis for identifying antifibrotic therapies such as oxidative stress, which are amenable to intervention. These studies will be critical for program development, appropriate interventions, and for improving health in this population.

抽象的肝病是美国艾滋病毒感染者死亡的主要原因。虽然在进步抗逆转录病毒治疗显着降低了艾滋病毒相关死亡率和丙型肝炎病毒合并感染 (HCV)，广泛存在并加速肝纤维化进展为肝硬化和肝癌。在此外，药物滥用会加速艾滋病毒的发病，并可能促进肝纤维化的进展。这该提案的主要目标是继续跟踪现有的迈阿密成人艾滋病毒研究 (MASH) 队列，其样本库和数据库，并将其从目前的 881 名研究参与者扩大到 1,500 名研究参与者。这目的是开展合作研究来调查可卡因的影响，可卡因是迄今为止最流行的南佛罗里达州滥用药物、艾滋病毒感染、艾滋病毒/丙型肝炎病毒合并感染以及长期发病率重点关注这一人群中的肝病，但获得护理的机会存在差异。未感染 HIV 和 HCV 的可卡因还将招募使用者和非使用者来确定可卡因单独使用的影响可卡因使用与 HIV、HCV 以及 HIV/HCV 合并感染之间的相互作用。作为新的和更有效的艾滋病毒、丙型肝炎病毒和药物滥用的治疗和护理变得可用，从而维持良好的特征队列、标本库和数据库将为当前的研究创建一个强大的资源平台。以及未来的合作研究。观察新的丙肝病毒治疗方法和潜在的新可卡因的使用情况针对存在健康差异的高危人群的戒烟计划将提供有关障碍和促进因素的数据采取有效的治疗方法来预防长期发病和死亡。我们追踪了 MASH 队列中的 881 人参与者长达 12 年，具有出色的保留率，并创建了样本库和数据库。迈阿密的 MASH 队列是独一无二的，因为它将主要是西班牙裔队列，并且有大量非裔美国人、妇女、非注射吸毒者（主要是异性恋艾滋病毒使用者）的数量传播病因学。我们建议（1）比较四年来肝纤维化的进展情况 HIV+/HCV-、HIV+/HCV+、HIV-/HCV+ 和 HIV-/HCV- 的可卡因使用者和非使用者，使用一种新型非侵入性诊断设备，磁共振弹性成像（MRE）。我们还建议（2）比较四年的生物标志物模式并识别与肝脏机制相关的遗传标志物可卡因使用者和非使用者之间的纤维化。了解可卡因使用在艾滋病毒和艾滋病毒背景下的作用 HIV/HCV 双重感染以及可卡因戒断治疗缺乏持久效果至关重要深入了解发病机制和疾病结果，并为识别抗纤维化提供基础诸如氧化应激之类的疗法，可以进行干预。这些研究对于计划的制定、适当的干预措施以及改善该人群的健康。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bidirectional associations between e-cigarette use and alcohol use across adolescence.

DOI：
10.1016/j.drugalcdep.2020.108496
发表时间：
2021-03-01
期刊：
Drug and alcohol dependence
影响因子：
4.2
作者：
Lozano A;Liu F;Lee TK;Prado G;Schwartz SJ;Leventhal AM;Kelleghan AR;Unger JB;Barrington-Trimis JL
通讯作者：
Barrington-Trimis JL

Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort.

DOI：
10.1371/journal.pone.0275675
发表时间：
2022
期刊：
PLOS ONE
影响因子：
3.7
作者：
Hernandez, Jacqueline;Tamargo, Javier A.;Martinez, Sabrina Sales;Martin, Haley R.;Campa, Adriana;Sekaly, Rafick-Pierre;Bordi, Rebeka;Sherman, Kenneth E.;Rouster, Susan D.;Meeds, Heidi L.;Khalsa, Jag H.;Mandler, Raul N.;Lai, Shenghan;Baum, Marianna K.
通讯作者：
Baum, Marianna K.

Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort.

DOI：
10.1080/09540121.2021.1896660
发表时间：
2022-05
期刊：
AIDS care
影响因子：
1.7
作者：
Degarege A;Krupp K;Tamargo J;Martinez SS;Campa A;Baum M
通讯作者：
Baum M

Effectiveness of a 6-Month Nutrition Intervention in People Living with HIV and Prediabetes Progressing through Stages of Change towards Positive Health Behavior.

DOI：
10.3390/ijerph192214675
发表时间：
2022-11-08
期刊：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
影响因子：
0
作者：
Sneij, Alicia;Campa, Adriana;Huffman, Fatma;George, Florence;Trepka, Mary Jo;Martinez, Sabrina Sales;Baum, Marianna
通讯作者：
Baum, Marianna

PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV.