Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

社区参与的针对服务不足和/或弱势群体的 COVID-19 检测研究

• 批准号: 10662839
• 负责人: Marianna K Baum
• 金额: $ 99.13万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10662839
• 关键词: Adult; African American population; Alcohols; Animal Experiments; Animals; Area; Behavioral; Biological Markers; Biological Specimen Banks; Biological Specimen database; COVID-19 testing; Cause of Death; Cessation of life; Cirrhosis; Clinical; Cocaine; Cocaine Abuse; Cocaine Users; Data; Databases; Diagnostic Equipment; Disease; Disease Outcome; Drug abuse; Etiology; FDA approved; Florida; Funding; Future; Genetic Markers; Goals; HIV; HIV Infections; HIV/HCV; Health; Health Services Accessibility; Hepatitis C; Hepatitis C Therapy; Hepatitis C co-infection; Hepatitis C virus; Heterosexuals; Hispanic; Hispanic Populations; Human; Immunity; Immunosuppression; In Vitro; Intervention; Laboratories; Liver Fibrosis; Liver diseases; Magnetic Resonance Elastography; Malnutrition; Metabolic; Morbidity - disease rate; Nature; Outcome; Oxidative Stress; Participant; Pathogenesis; Pattern; Persons; Pharmaceutical Preparations; Pharmacotherapy; Population; Populations at Risk; Primary carcinoma of the liver cells; Prognostic Factor; Program Development; Program Evaluation; Quality of life; Recording of previous events; Research; Research Design; Resources; Risk Factors; Role; Signal Transduction; Stimulus; Substance abuse problem; Treatment Failure; Underserved Population; United States; United States National Institutes of Health; Virus Diseases; Vulnerable Populations; Woman; antifibrotic treatment; antiretroviral therapy; chronic liver disease; co-infection; cocaine use; cohort; community engaged research; comorbidity; cytokine; data harmonization; drug of abuse; effective intervention; effective therapy; evidence base; fibrogenesis; follow-up; health care availability; health disparity; health disparity populations; improved; insight; interest; liver development; mortality; noninvasive diagnosis; novel; prevent; programs; prospective; recruit; retention rate; sociodemographics; time interval; transmission process; treatment effect; uptake

ABSTRACT Liver disease is a major cause of death in HIV infected persons in the United States. While advances in antiretroviral therapy have significantly reduced HIV-related mortality, co-infection with hepatitis C virus (HCV), is widespread and accelerates progression of liver fibrosis to cirrhosis and liver carcinoma. In addition, substance abuse accelerates HIV disease, and may facilitate progression of liver fibrosis. The primary goal of this proposal is to continue to follow the existing Miami Adult Studies on HIV (MASH) cohort, its specimen repository and database, and expand it from the current 881 to 1,500 study participants. The purpose is to generate collaborative studies to investigate the impact of cocaine, by far the most prevalent drug of abuse in South Florida, on HIV infection, HIV/HCV co-infection, and on long-term morbidity with a focus on liver disease in this population with disparities in access to care. HIV and HCV un-infected cocaine users and non-users will also be recruited to allow determination of the impact of cocaine use alone, as well as the interaction of cocaine use with HIV, HCV, and HIV/HCV co-infection. As new and more effective treatments and access to care for HIV, HCV and drug abuse become available, maintaining a well- characterized cohort, specimen repository and database will create a strong resource platform for current and future collaborative research. Observing the uptake of new HCV treatments and potential new cocaine cessation programs in this at-risk population with health disparities will provide data on barriers and facilitators to effective treatments to prevent long-term morbidity and mortality. We have followed the MASH cohort of 881 participants for up to 12 years with excellent retention rates, and have created a specimen repository and a database. The MASH cohort in Miami is unique because it will be a mostly Hispanic cohort with a large number of African Americans, women, non-injector drug users, with predominantly heterosexual HIV- transmission etiology. We propose to (1) compare the progression of liver fibrosis over four years among cocaine users and non-users in HIV+/HCV-, HIV+/HCV+, HIV-/HCV+, and HIV-/HCV-, using a novel non- invasive diagnostic device, the Magnetic Resonance Elastography (MRE). We also propose to (2) compare the pattern over four years of biomarkers and identify genetic markers associated with the mechanisms of liver fibrosis among cocaine users and non-users. Understanding the role of cocaine use in the context of HIV and HIV/HCV co-infections and lack of lasting effects of treatments for cocaine use cessation are crucial in order to gain insights into the pathogenesis and disease outcomes, and to provide the basis for identifying antifibrotic therapies such as oxidative stress, which are amenable to intervention. These studies will be critical for program development, appropriate interventions, and for improving health in this population.

抽象的 肝病是美国受艾滋病毒感染者的主要死亡原因。而进步 抗逆转录病毒疗法显着降低了与HIV相关的死亡率，与丙型肝炎病毒共同感染 （HCV），是广泛的，并加速了肝纤维化向肝硬化和肝癌的进展。在 此外，药物滥用会加速艾滋病毒疾病，并可能促进肝纤维化的进展。这 该提案的主要目标是继续遵循现有的迈阿密成人研究（MASH）队列研究， 它的标本存储库和数据库，并将其从当前的881个研究参与者扩展到1,500名。这 目的是生成协作研究以调查可卡因的影响，迄今为止是最普遍的 南佛罗里达州的滥用药物，HIV感染，HIV/HCV共同感染以及长期发病率 专注于在接受护理方面差异的人群中的肝病。 HIV和HCV未感染的可卡因 还将招募用户和非用户，以确定仅可卡因使用的影响 作为可卡因与HIV，HCV和HIV/HCV共同感染的相互作用。作为新的，更有效的 可用的治疗和治疗艾滋病毒，HCV和药物滥用的机会，保持良好 表征的队列，标本存储库和数据库将为当前创建一个强大的资源平台 以及未来的协作研究。观察新的HCV治疗和潜在的新可卡因的摄取 这种具有健康差异的高风险人口中的戒烟计划将提供有关障碍和促进者的数据 有效治疗以防止长期发病率和死亡率。我们遵循了881的土豆泥队列 参与者长达12年，保留率很高，并创建了标本存储库和一个 数据库。迈阿密的MASH队列是独一无二的，因为它将是一个大部分的西班牙裔人群 非裔美国人，妇女，非注射药物使用者的数量，主要是异性恋HIV- 传播病因。我们建议（1）在四年中比较肝纤维化的进展 使用新颖的非 - 非新型非 - 侵入性诊断装置，磁共振弹性图（MRE）。我们还建议（2）比较 在四年的生物标志物中的模式，并确定与肝脏机制相关的遗传标记 可卡因使用者和非用户之间的纤维化。了解可卡因在艾滋病毒和 HIV/HCV的共同感染以及可卡因使用戒烟的持久影响至关重要 洞悉发病机理和疾病结果，并为识别抗纤维化提供基础 诸如氧化应激之类的疗法，可以接受干预。这些研究对于 计划开发，适当的干预措施以及改善该人群的健康状况。

项目成果

Bidirectional associations between e-cigarette use and alcohol use across adolescence.

• DOI: 10.1016/j.drugalcdep.2020.108496
• 发表时间: 2021-03-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Lozano A;Liu F;Lee TK;Prado G;Schwartz SJ;Leventhal AM;Kelleghan AR;Unger JB;Barrington-Trimis JL
• 通讯作者: Barrington-Trimis JL

Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort.

• DOI: 10.1371/journal.pone.0275675
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Hernandez, Jacqueline;Tamargo, Javier A.;Martinez, Sabrina Sales;Martin, Haley R.;Campa, Adriana;Sekaly, Rafick-Pierre;Bordi, Rebeka;Sherman, Kenneth E.;Rouster, Susan D.;Meeds, Heidi L.;Khalsa, Jag H.;Mandler, Raul N.;Lai, Shenghan;Baum, Marianna K.
• 通讯作者: Baum, Marianna K.

Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort.

• DOI: 10.1080/09540121.2021.1896660
• 发表时间: 2022-05
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Degarege A;Krupp K;Tamargo J;Martinez SS;Campa A;Baum M
• 通讯作者: Baum M

Effectiveness of a 6-Month Nutrition Intervention in People Living with HIV and Prediabetes Progressing through Stages of Change towards Positive Health Behavior.

• DOI: 10.3390/ijerph192214675
• 发表时间: 2022-11-08
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Sneij, Alicia;Campa, Adriana;Huffman, Fatma;George, Florence;Trepka, Mary Jo;Martinez, Sabrina Sales;Baum, Marianna
• 通讯作者: Baum, Marianna

PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV.

• DOI: 10.3390/biology10030242
• 发表时间: 2021-03-21
• 期刊: Biology
• 影响因子: 4.2
• 作者: Sherman KE;Rouster SD;Meeds H;Tamargo J;Chen J;Ehman R;Baum M
• 通讯作者: Baum M