Bioinformatics Core

生物信息学核心

基本信息

批准号：
10403551
负责人：
SUSAN J. BROWN
金额：
$ 56.77万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-18 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10403551
关键词：
Address Applications Grants Award Bioinformatics Biological Sciences Biology Biomedical Research Biometry Cellular biology Clinical Collaborations Complex Computers Course Content Data Analyses Data Set Databases Development Developmental Biology Educational Curriculum Educational workshop Experimental Designs Faculty Fostering Genome Genomics Goals High Performance Computing Informatics Institution Kansas Lead Methods Molecular Postdoctoral Fellow Publications Quantitative Genetics Recording of previous events Research Research Personnel Research Project Grants Research Support Resource Development Resources Scholarship Science Scientist Site Specialist Students System Technology Training Universities Work bioinformatics pipeline clinical translation cluster computing computing resources cyber infrastructure design developmental genetics distinguished professor experimental study genome sequencing innovation large datasets mid-career faculty multidisciplinary next generation next generation sequencing practical application professor response tool training opportunity transcriptome sequencing transcriptomics undergraduate research experience undergraduate student

项目摘要

PROJECT ABSTRACT The K-INBRE Bioinformatics Core promotes cutting edge research in Cell and Developmental Biology by addressing requirements for computational resources within the K-INBRE Network, providing expertise to solve complex problems in data analysis, and developing a statewide system to train the next generation of researchers. Supported by advances in Next Generation Sequencing (NGS) technology, the Bioinformatics Core will continue to focus on genomics, transcriptomics, and genome biology. The Director of the K-INBRE Bioinformatics Core, S. Brown, KSU University Distinguished Professor in Biology, is an expert in genome sequencing, mapping, and informatics. She is joined by Assistant Professor of Biostatistics D. Koestler, a statistical genomicist, as Satellite Core Director at KUMC, and Associate Professor of Molecular Biosciences S. Macdonald, a quantitative geneticist, as the Satellite Core Director at KU-L. Together, these Bioinformatics Core directors leverage their expertise in Genomics, Genome Biology, Developmental Genetics, Quantitative Genetics, and Biostatistics to provide research support, training opportunities, and educational curricula in support of scientists using NGS approaches to address research problems in cell and developmental biology across the K-INBRE network. The Bioinformatics Core staff have assembled teams of bioinformaticians, biostatisticians, and computer specialists to: 1) work with biomedical researchers in designing experiments, analyzing data, and interpreting results that lead to publication and grant application; 2) collaborate with high performance computing centers at KSU (Beocat) and KU-L (KU-CRC) to provide access to the cyberinfrastructure required to transfer, store, analyze, and interpret large data sets; 3) develop pipelines and databases that foster collaboration, multidisciplinary science, and clinical translation; 4) provide training opportunities in the form of workshops, seminars, and student research scholarships that will facilitate practical application of these resources by K- INBRE students, postdoctoral fellows, and faculty; and 5) develop course curricula to train the next generation of biomedical researchers in genomics, bioinformatics, and biostatistics. Overall, the Bioinformatics Core has had excellent progress and is proactive in developing a new pipeline of bioinformatics scholars in Kansas.

项目摘要 K Inbre的生物信息学核心促进了细胞和发育生物学的最先进研究解决K-Inbre网络中计算资源的要求，提供专业知识来解决数据分析中的复杂问题，并开发了一个全州系统，以训练下一代研究人员。在下一代测序（NGS）技术中的进步支持下，生物信息学核心将继续关注基因组学，转录组学和基因组生物学。 K-Inbre的主任生物信息学核心，S。Brown，KSU大学生物学杰出教授，是基因组的专家测序，映射和信息学。她与生物统计学助理教授D. Koestler一起加入了她的行列统计基因组学家，KUMC的卫星核心主任和分子生物科学副教授。麦克唐纳（MacDonald）是一位定量遗传学家，是KU-L的卫星核心主管。这些生物信息学核心在一起导演利用其在基因组学，基因组生物学，发育遗传学，定量方面的专业知识遗传学和生物统计学，以提供研究支持，培训机会和教育课程使用NGS方法来解决细胞和发育生物学研究问题的科学家的支持跨K-INBRE网络。生物信息学的核心人员组成了生物信息学家，生物统计学家和计算机的团队专家：1）与生物医学研究人员一起设计实验，分析数据和解释导致出版和授予申请的结果； 2）与高性能计算中心合作 KSU（beocat）和Ku-L（Ku-Crc），可访问转移，存储，存储所需的网络基础设施分析并解释大型数据集； 3）开发促进协作的管道和数据库，多学科科学和临床翻译； 4）以研讨会的形式提供培训机会，研讨会和学生研究奖学金将促进K-实际应用这些资源 inbre学生，博士后研究员和教职员工； 5）开发课程课程以培训下一代基因组学，生物信息学和生物统计学的生物医学研究人员的研究。总体而言，生物信息学核心具有在堪萨斯州开发新的生物信息学学者的新渠道方面取得了出色的进步，并积极主动。