Post-Doctoral Training in Joint Health

关节健康博士后培训

• 批准号: 10636625
• 负责人: D Rick Sumner
• 金额: $ 20.18万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10636625
• 关键词: Health; Joints; post-doctoral training

We propose a post-doctoral training program in the multi-disciplinary area of musculoskeletal biology with the ultimate aim of developing future leaders in orthopedic- and rheumatology-related research. The program emphasizes research training in joint health, encompassing three major programmatic areas: osteoarthritis, total joint replacement and small molecule therapeutics. Dr. Rick Sumner (Cell & Molecular Medicine) will serve as the principal investigator with Dr. Anne-Marie Malfait (Internal Medicine-Rheumatology) and Dr. Markus Wimmer (Orthopedic Surgery) as the co-directors. We are requesting support for three post-doctoral fellows and three short-term trainees. Joint health is a theme that connects many departments at Rush, offering an environment and intellectual capital available to post-doctoral fellows that is unique in the nation. The multidisciplinary training that is offered integrates the research endeavors of scientists in basic science and clinical departments with clinician investigators, caregivers, and educators who specialize in musculoskeletal disease and joint health. The training themes for this grant represent the strengths of the preceptors who have been selected as mentors. Training will take place in the laboratories of 19 faculty in two basic science departments (Cell & Molecular Medicine and Physiology & Biophysics) and three clinical departments (Internal Medicine, Orthopedic Surgery and Pediatrics). There are currently 40 post-doctoral trainees in these departments, with 22 advised by preceptors on this application. These 19 faculty are principal investigators on grants totaling $8.4M in annual direct costs, including 31 R01 or R01 equivalent grants and 16 other grants. Our primary focus will be on training PhD post-doctoral fellows, but we will make every effort to recruit candidates with clinical training into our program. One means to encourage interest among clinical trainees is to provide meaningful introductory research experiences. Thus, we will include short-term trainees (medical students) in our program. There is a deep history of collaborative research among musculoskeletal researchers at Rush. We will take advantage of a very strong mentoring program and an active post-doctoral research society that has created a vibrant community for trainees. Our training plan focuses on the six competencies defined by the National Postdoctoral Association: Discipline-specific conceptual knowledge, Research skill development, Communication skills, Professionalism, Leadership and management skills, and Responsible conduct of research. Each mentee, his/her primary advisor and personalized mentoring committee will use individual development plans to guide their efforts with a focus on publishing and participating in national research meetings and submitting independent grants. We anticipate that trainees will be assigned to the T32 for two years with the expectation that support will transfer to individual awards (e.g., F32’s) or their preceptors’ grants. After completing our program, we expect the trainees to continue in science as independent, team-oriented, investigators.

我们在肌肉骨骼生物学的多学科领域提出了一项博士后培训计划 在与风湿病相关的研究中发展未来领导者的最终目标。该程序 强调联合健康的研究培训，包括三个主要的程序化领域：骨关节炎， 总关节置换和小分子治疗。里克·萨姆纳（Rick Sumner）博士（细胞和分子医学）将 担任Anne-Marie Malfait博士（内科生）和博士的首席研究员 Markus Wimmer（骨科手术）作为联合导演。我们要求支持三个博士后 研究员和三名短期学员。联合健康是连接Rush许多部门的主题 为全国独特的博士后研究员提供环境和智力资本。 提供的多学科培训综合了基础科学科学家的研究努力 以及专门研究的临床研究人员，看护人和教育者的临床部门 肌肉骨骼疾病和关节健康。该赠款的培训主题代表了 被选为导师的主持人。培训将在19位教职员工的实验室中进行 基础科学系（细胞与分子医学与生理与生物物理学）和三个临床 部门（内科，骨科手术和儿科）。目前有40个博士后 这些部门的受训人员，有22名受体在此申请上建议。这19位教师是校长 赠款的调查人员总计840万美元的直接费用，包括31 R01或R01等效赠款和16个 其他赠款。我们的主要重点将是培训博士后博士研究员，但我们将尽一切努力 通过临床培训招募候选人参加我们的计划。一种鼓励临床有趣的有趣的方法 学员将提供有意义的介绍研究经验。那我们将包括短期学员 （医学生）在我们的计划中。肌肉骨骼之间有一段深刻的合作研究历史 拉什的研究人员。我们将利用一个非常强大的心理计划和活跃的博士后 为学员创造了一个充满活力的社区的研究社会。我们的培训计划着重于六个 国家博士后协会定义的能力：特定学科的概念知识， 研究技能发展，沟通技巧，专业精神，领导和管理技能，以及 负责任的研究。每个导师，他/她的主要顾问和个性化指导 委员会将使用个人发展计划来指导他们的努力，专注于出版和 参加国家研究会议并提交独立赠款。我们预计受训者会 被分配给T32两年，期望支持将转移到个人奖励（例如， F32）或他们的教育者的赠款。完成计划后，我们希望受训者继续科学 作为独立，面向团队的调查人员。

项目成果

The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19.

• DOI: 10.3389/fmed.2021.797647
• 发表时间: 2021
• 期刊: Frontiers in medicine
• 影响因子: 3.9
• 作者: Hamilton JL;Vashi M;Kishen EB;Fogg LF;Wimmer MA;Balk RA
• 通讯作者: Balk RA

A MOVING CONTACT OF ARTICULATION ENHANCES THE BIOSYNTHETIC AND FUNCTIONAL RESPONSES OF ARTICULAR CARTILAGE.

关节的移动接触增强了关节软骨的生物合成和功能反应。

• DOI: 10.1016/j.biotri.2021.100180
• 发表时间: 2021
• 期刊: Biotribology (Oxford)
• 作者: Shekhawat,VivekK;Hamilton,JohnL;Pacione,CarolA;Schmid,ThomasM;Wimmer,MarkusA
• 通讯作者: Wimmer,MarkusA

The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats.

• DOI: 10.1096/fj.202001364r
• 发表时间: 2020-11
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Moran MM;Wilson BM;Li J;Engen PA;Naqib A;Green SJ;Virdi AS;Plaas A;Forsyth CB;Keshavarzian A;Sumner DR
• 通讯作者: Sumner DR

Therapeutic assessment of N-formyl-methionyl-leucyl-phenylalanine (fMLP) in reducing periprosthetic joint infection.

• DOI: 10.22203/ecm.v042a09
• 发表时间: 2021-08-26
• 期刊: European cells & materials
• 影响因子: 3.1
• 作者: Hamilton JL;Mohamed MF;Witt BR;Wimmer MA;Shafikhani SH
• 通讯作者: Shafikhani SH

The Use of Serum Procalcitonin in the Setting of Infected Ureteral Stones: A Prospective Observational Study.

血清降钙素原在感染输尿管结石治疗中的应用：一项前瞻性观察研究。

• DOI: 10.1089/end.2020.0308
• 发表时间: 2021
• 期刊: Journal of endourology
• 影响因子: 2.7
• 作者: Capoccia,Edward;Whelan,Patrick;Sherer,Benjamin;Tsambarlis,Pete;Tan,WeiPhin;Chow,Alexander;Farrell,MichaelRyan;Patel,Brijesh;Setia,Shaan;Wilson,BrittanyM;Zhang,Yanyu;Papagiannopoulos,Dimitri
• 通讯作者: Papagiannopoulos,Dimitri