Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

人类颞下颌外侧囊韧带的组织结构和机械功能关系：性别和种族二态性的调查

• 批准号: 10525626
• 负责人: Cherice Natasha Hill
• 金额: $ 10.77万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10525626
• 关键词: Adult; Affect; African American population; Appointment; Articulation; Biochemical; Biological Assay; Biology; Biomechanics; Biomedical Engineering; Characteristics; Charge; Chemicals; Chronic; Collagen; Complex; Development; Dislocations; Elements; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; Evaluation; Faculty; Family; Fellowship; Female; Generations; Glycosaminoglycans; Goals; Human; Incidence; Investigation; Joints; Lateral; Ligaments; Literature; Low Prevalence; Mandibular Condyle; Manuscripts; Mechanics; Mentors; Microscopy; Modeling; Molecular; Molecular and Cellular Biology; Morphology; Pain; Pathologic; Pathology; Pathway interactions; Patients; Phase; Population Heterogeneity; Postdoctoral Fellow; Preparation; Prevalence; Property; Protocols documentation; Race; Relaxation; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Resource Development; Resources; Risk; Risk Assessment; Risk Estimate; Risk Factors; Sampling; Sex Differences; Stress; Structure; Symptoms; System; Temporal bone structure; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Time; Tissues; Training; Translational Research; United States; United States National Institutes of Health; Universities; Woman; Work; Writing; biomechanical test; capsule; caucasian American; chemical property; clinical care; craniofacial; density; dimorphism; experience; high risk; joint destruction; joint loading; male; men; post-doctoral training; programs; racial difference; racial disparity; resilience; responsible research conduct; second harmonic; sex; sex determination; sex disparity; sexual dimorphism; skill acquisition; social; statistics; success; viscoelasticity

Project Summary/Abstract As many as 10 million adults in the United States have temporomandibular disorders (TMDs). Females experience TMDs at higher rates compared to males and African Americans have higher TMD incidence, yet lower prevalence compared to white Americans. Despite these findings, etiological mechanisms contributing to prevalence and incidence disparities by sex and race are largely unknown. Given our recent reports on sexual dimorphisms in incremental tensile stiffness and fixed charge density of the human temporomandibular disc, it is hypothesized that additional sexual dimorphisms may exist in properties of the temporomandibular joint (TMJ). Similar differences are also hypothesized to exist between racial groups, although this possibility has not yet been explored, which may limit research translational confidence across racial groups. The lateral capsule- ligament (LCL) complex, which spans the temporal bone and mandibular condyle, could impact temporomandibular disc derangement (TMDD) risk through a ‘loose ligament’ mechanism affecting joint articulation postulated in prior literature. Furthermore, sex- and race-specific differences in potential risk and resiliency factors may contribute to differential risk of TMDD development and observed TMD prevalence and incidence disparities. Our long-term goal is to enable individualized TMDD risk assessment to increase applicability of generated risk estimates. The objective of this study is to describe sex- and race-specific mechano-chemical LCL complex properties to investigate potential contributions to TMD disparities between sexes and racial groups. The central hypothesis is that TMJ properties observed in females and African Americans will be associated with higher risk of TMDD development compared to those of males and white Americans. The proposed studies will enable the determination of sex- and race-specific differences in potential mechanical and chemical risk factors for TMD development (Aims 1 and 2). This determination will contribute to a better understanding of TMJ properties across diverse populations and is crucial to enabling understanding of TMD incidence and prevalence disparities. Finite element models will also be used to investigate how differences between sexes and racial groups impact the temporomandibular loading environment, which will be developed, refined, and interpreted during the independent phase (Aim 3). This proposal aims to further development of scientific expertise and skill acquisition in temporomandibular and craniofacial biomechanics, with a plan to transition from mentored post-doctoral fellowship to independent faculty. NIH T32 training and professional development resources, joint resources and network of the Clemson- MUSC Bioengineering program, and the Clemson University Pathways Mentoring Program provide an ideal inter-disciplinary training environment to prepare for and transition to independence following the postdoctoral fellowship period.

项目摘要/摘要 在美国，多达1000万成年人患有颞下颌疾病（TMD）。女性 与男性和非裔美国人相比，以较高的比率体验TMD的TMD事件更高，但是 与美国白人相比，患病率较低。尽管有这些发现，病因机制有助于 性别和种族因性和种族而出现的差异在很大程度上是未知的。考虑到我们最近的性报告 人类颞下颌盘的增量拉伸刚度和固定电荷密度的二态性， 假设在颞下颌关节（TMJ）的性质中可能存在其他性二态性。 种族群体之间也存在类似的差异，尽管这种可能性尚未 探索了探索，这可能会限制种族群体之间的研究翻译信心。侧囊 - 涉及临时骨和下颌con的韧带（LCL）复合物可能会影响 通过影响关节的“松散韧带”机制，颞下颌圆盘进化（TMDD）风险 发表在先前的文献中发布。此外，潜在风险的性别和种族特异性差异 弹性因素可能有助于TMDD开发的差异风险，并观察到TMD患病率和 发病率分布。我们的长期目标是使个性化的TMDD风险评估增加 生成的风险估计的适用性。这项研究的目的是描述性别和种族特定的 机械化学LCL复合物特性，以研究对TMD分布的潜在贡献 在性别和种族群体之间。中心假设是在女性和 与男性相比，非裔美国人将与TMDD发展的风险更高有关 美国白人。拟议的研究将使性别和种族特定的差异确定 TMD开发的潜在机械和化学危险因素（目标1和2）。这种决心将 有助于更好地理解潜水员种群的TMJ特性，对于实现 了解TMD事件和患病率分布。有限元模型也将用于 调查性别与种族群体之间的差异如何影响颞下颌负荷 环境将在独立阶段开发，完善和解释（AIM 3）。这 提案旨在进一步发展颞下颌和方面的科学专业知识和技能 颅面生物力学，并计划从修订后的博士后奖学金过渡到独立 学院。 NIH T32培训和专业发展资源，Clemson的联合资源和网络 - MUSC生物工程计划和克莱姆森大学途径指导计划提供了理想 跨学科的培训环境，以准备和过渡到博士后之后向独立过渡 团契期。