2/2 Partnerships to Enhance Alcohol Research Across NCCU and UNC (PEAR-NC)

2/2 加强 NCCU 和 UNC 酒精研究的合作伙伴关系 (PEAR-NC)

• 批准号: 10705685
• 负责人: FULTON T CREWS
• 金额: $ 31.1万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705685
• 关键词: ARHGEF5 gene; Address; Adolescent; Adult; African American; African American population; African American student; Alcohol abuse; Alcohols; Area; Award; Behavioral; Brain; Collaborations; Core Facility; Course Content; Data; Education; Educational Curriculum; Educational process of instructing; Endowment; Environment; Ethanol toxicity; Faculty; Fetal Alcohol Spectrum Disorder; Funding; Future; Goals; Grant; Health Professional; Historically Black Colleges and Universities; Inflammation; Infrastructure; Institution; Internships; Joints; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Manuscripts; Medical; Medical Libraries; Mentors; Minority; Molecular; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neuroimmune; North Carolina; Pathology; Preparation; Process; Productivity; Publications; Research; Research Personnel; Research Project Grants; Research Technics; Resource Sharing; Resources; Scholarship; Series; Severities; Structure; Students; Techniques; Tissues; Toxic effect; Training; U-Series Cooperative Agreements; Underrepresented Minority; United States National Institutes of Health; Universities; Work; alcohol exposure; alcohol research; alcohol use disorder; carcinogenesis; career; cellular pathology; expectation; experience; experimental study; faculty mentor; fetal; graduate student; health disparity; improved; interest; laboratory development; laboratory experience; lectures; malignant breast neoplasm; mammary; medical schools; meetings; minority investigator; neuropathology; neurotoxicity; post-doctoral training; programs; recruit; research and development; response; role model; skills; stem cells; success; summer internship; synergism; undergraduate student; underrepresented minority student; university student; virology

This is an application for a cooperative agreement (U54), “Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC),” between faculties of North Carolina Central University (NCCU), a Historically Black College or University, and the Bowles Center for Alcohol Studies (BCAS) at the University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this Alcohol and Health Disparities program. Within this proposal, an NCCU Administrative Core and three Research Components will integrate with the UNC-BCAS Administrative Research Components, as well as other activities at the Bowles Center for Alcohol Studies. The UNC NIAAA Alcohol Research Center (ARC) and BCAS have many faculty studying mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that allow collaborative research partnerships on common areas of interest between UNC and NCCU faculty. These partnerships open UNC research laboratories, core facilities, and medical libraries to NCCU faculty, improving opportunities for developing productive research laboratories at NCCU. In addition, due to recent NCCU NIAAA R awards, large numbers of NCCU students will continue to become involved in research on mechanisms of alcohol pathology, providing education on African American alcohol-related health disparities which are due to increased morbidity to alcohol-related pathologies and not increased alcohol use disorder. The objective of this U54 partnership is to investigate molecular mechanisms of alcohol-induced cellular pathology. This proposal includes three NCCU research projects, involving six NCCU faculty, that will investigate the molecular mechanisms of fetal alcohol pathology, alcohol-induced mammary stem cell toxicity, and neuroimmune responses in adolescent and adult brain. A second objective is to provide research experiences and scholarly education on alcohol pathology for NCCU students. The educational efforts in this proposal will involve NCCU undergraduate and graduate students through the BCAS seminar series, through training in UNC laboratories and research development and mentor meetings, attendance and presentation of data at the annual RSA meeting, an alcohol seminar series hosted by NCCU, new course curricula on alcohol pathology developed with a focus on health disparities, as well as specific undergraduate student summer internships for NCCU students to study and learn about alcohol pathology and health disparities within laboratories in both institutions. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an active and successful alcohol research program within NCCU that synergizes with UNC to advance education and discoveries.

这是合作协议（U54）的申请：“合作伙伴关系，以增强跨越酒精研究 NCCU和UNC（Pear-NC）”，北卡罗来纳州中央大学（NCCU）之间，历史上 黑人学院或大学，以及北大学的鲍尔斯酒精研究中心（BCAS） 卡罗来纳州（UNC）医学院。该建议代表了NCCU之间的真正合作努力 以及两组的UNC教职 酒精和健康差异计划。在此提案中，NCCU行政核心和三个 研究组件将与UNC-BCAS行政研究组件以及 鲍尔斯酒精研究中心的其他活动。 UNC NIAAA酒精研究中心（ARC）和 BCA有许多教师研究酒精病理学的机制，跨行为，组织， 与酒精暴露有关的细胞病理。该建议将重点放在细胞病理上 允许对UNC和NCCU教师之间感兴趣的共同领域的合作研究合作伙伴关系。 这些合作伙伴关系为NCCU教师开放UNC研究实验室，核心设施和医疗图书馆， 改善NCCU开发产品研究实验室的机会。此外，由于最近 NCCU NIAAA R奖，大量NCCU学生将继续参与研究 酒精病理学机制，提供有关非裔美国酒精相关健康分配的教育 这是由于对酒精相关病理的发病率增加而没有增加酒精使用障碍。 该U54合作伙伴关系的目的是研究酒精诱导的细胞的分子机制 病理。该建议包括三个NCCU研究项目，涉及六个NCCU教职员工 研究胎儿酒精病理学的分子机制，酒精诱导的乳腺干细胞毒性， 和青少年和成人大脑的神经免疫反应。第二个目标是提供研究 NCCU学生的酒精病理学经验和科学教育。在这方面的教育工作 提案将通过BCAS研讨会系列涉及NCCU的本科生和研究生 在UNC实验室和研究开发和心理会议，出席和介绍中进行培训 在年度RSA会议上的数据，NCCU主办的酒精液体系列，关于酒精的新课程 病理学以健康分布以及特定的本科生夏季发展而发展 NCCU学生的实习，以学习和了解酒精病理学和健康分布 这两个机构的实验室。最终，该建议将进行，促进，支持和心理研究 进入酒精病理学机制，在内部创建积极而成功的酒精研究计划 NCCU与UNC协同促进教育和发现。