UNC-CH NADIA Scientific Core

UNC-CH NADIA 科学核心

基本信息

批准号：
8034043
负责人：
FULTON T CREWS
金额：
$ 43.62万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8034043
关键词：
Acetylcholine Address Adolescence Adolescent Adult Affect Alcohol consumption Alcohols Anatomy Animal Model Archives Area Arts Atlases Behavior Behavioral Brain Brain region Cholecystokinin Complex Control Animal Data Data Analyses Data Set Databases Decision Making Development Diffusion Magnetic Resonance Imaging Dopamine Dysmorphology Ethanol Fiber Foundations Future Gene Expression Histology Image Image Analysis Immunohistochemistry Interneurons Life Link Magnetic Resonance Imaging Maps Measures Methods Modeling Mus Neurons Neurotransmitters Norepinephrine Peptides Phenotype Physiology Property Prosencephalon Proteins Rattus Research Research Infrastructure Research Project Grants Resolution Rewards Scanning Serotonin Slice Structure Synapses System Tissues alcohol exposure base brain morphology brain tissue computational anatomy gamma-Aminobutyric Acid indexing interest multidisciplinary neurobehavioral neurobiological mechanism neurochemistry protein expression public health relevance receptor repository tool underage drinking web site

项目摘要

DESCRIPTION (provided by applicant): The primary objective of this NADIA core is to integrate and expand the Consortium research projects. The hypothesis of the Scientific Core is that adolescent intermittent ethanol (AIE) impacts brain development and induces specific neuro-adaptations that persist into adulthood as a specific neurochemical and morphological phenotype. Thus, the Scientific Core will serve and link NADIA components by providing neurochemical and morphological brain atlases that will define the phenotype of the brain exposed to alcohol during adolescence. Each component will send brains to the core for immunohistochemical determination of pivotal neurotransmitter gene expression in brain regions related to the physiology and behaviors being studied. Additionally, Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data will be collected on select data sets in order to provide global structural information on the impact of different AIE models on adult brain. Finally, all the resulting data will be shared and unused brain tissue will be archived to allow for future analysis. Together, these approaches will provide critical information on neurobiological mechanisms that underlie AlE-induced changes in adult behavior and physiology. The Scientific Core will use an animal model of adolescence alcohol drinking to investigate how alcohol changes brain structure and neurochemistry. This endeavor, along with the resulting data repository, serves to integrate the research components of the NADIA Consortium and will provide a foundation for understanding differences in adolescent life trajectories and maturation of important behavioral repertoires. PUBLIC HEALTH RELEVANCE: The Scientific Core will use an animal model of adolescence alcohol drinking to investigate how alcohol changes brain structure and neurochemistry. This endeavor, along with the resulting data repository, serves to integrate the research components of the NADIA Consortium and will provide a foundation for understanding differences in adolescent life trajectories and maturation of important behavioral repertoires.

描述（由申请人提供）：该 NADIA 核心的主要目标是整合和扩展联盟研究项目。科学核心的假设是，青少年间歇性乙醇（AIE）会影响大脑发育并诱导特定的神经适应，这种适应会以特定的神经化学和形态表型的形式持续到成年期。因此，科学核心将通过提供神经化学和形态学大脑图谱来服务和连接 NADIA 组件，这些图谱将定义青春期暴露于酒精的大脑的表型。每个组件都会将大脑发送到核心，以免疫组织化学测定与所研究的生理和行为相关的大脑区域中的关键神经递质基因表达。此外，还将在选定的数据集上收集磁共振成像 (MRI) 和扩散张量成像 (DTI) 数据，以便提供有关不同 AIE 模型对成人大脑影响的全局结构信息。最后，所有产生的数据将被共享，未使用的脑组织将被存档以供将来分析。总之，这些方法将提供有关 AlE 引起的成人行为和生理变化的神经生物学机制的关键信息。科学核心将使用青春期饮酒的动物模型来研究酒精如何改变大脑结构和神经化学。这项努力以及由此产生的数据存储库，有助于整合 NADIA 联盟的研究组成部分，并将为理解青少年生活轨迹的差异和重要行为能力的成熟提供基础。公共健康相关性：科学核心将使用青春期饮酒的动物模型来研究酒精如何改变大脑结构和神经化学。这项努力以及由此产生的数据存储库，有助于整合 NADIA 联盟的研究组成部分，并将为理解青少年生活轨迹的差异和重要行为能力的成熟提供基础。