Pilot Projects

试点项目

• 批准号: 8410353
• 负责人: FULTON T CREWS
• 金额: $ 6.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-10 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8410353
• 关键词: Alcohol consumption; Alcoholic Hepatitis; Alcoholism; Attenuated; Award; Brain; Clinical; Clinical Research; Data; Ethanol; Faculty; Feasibility Studies; Funding; Goals; Grant; Growth; Growth and Development function; Interleukin-1; Interleukin-13; Investigation; Lead; Liver; Mediating; Molecular; Mus; Pathogenesis; Patients; Pilot Projects; Process; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Science; Scientist; Severity of illness; Small Interfering RNA; Testing; Translational Research; Translations; United States National Institutes of Health; alcohol research; alcoholism therapy; base; binge drinking; design; drinking; innovation; liver inflammation; liver injury; programs; receptor; success; translational study

The Pilot Project program is designed to promote alcohol research across the UNC campus. We provide funds to new investigators without current or past research support and to established investigators who propose projects that represent a significant departure from their ongoing research. The goal of the program is to provide sufficient funds to generate pilot data on alcohol research projects that can be used to support applications for research grants. A detailed review process includes Internal solicitation for proposals, involvement and advice from appropriate Center faculty, as well as internal and external review to select studies of the highest quality. The pilot program also takes advantage of funds from the NC Clinical and Translational Research Consortium (NIH Clinical Translation, Science Award) that will match funding by the ARC to outstanding proposals. Previous pilot projects funded by our Center grant have led to new NIH funding for UNC researchers. This process brings new people and new ideas into the center, renewing Its vibrance and innovation and helping to keep us on the forefront of the field. This ARC includes two Pilot Projects (Project 16 and 17) as part of this proposal. Both projects integrate nicely with our theme of ALCOHOL PATHOGENESIS. Project 16 (Ramon Bataller, PI) will test whether p90RSK mediates liver injury and inflammation in alcoholic hepatitis (AH). His group will conduct a translational study with liver samples from patients, where p90RSK expression and activation will be determined and correlated with disease severity. Next, they will investigate whether p90RSK inhibition in mice with experimental AH attenuates liver Injury and inflammation. Project 17 (Donald Lysle, PI) will examine the role of interteukin-1|3 (IL-1 (3) In ethanol binge drinking. His group will test the hypotheses that repeated binge-like drinking increases IL-1 (3 expression in brain and that blocking 1L-1(3 using small interfering RNA (siRNA) or IL-13 receptor antagonist will protect against binge-like ethanol drinking. These Pilot Projects will provide the resources for new investigators to develop preliminary findings important for success In larger research grants. This effort supports the long term growth and success of our ARC.

试点项目计划旨在促进整个UNC校园的酒精研究。我们为新的研究人员提供资金，而没有当前或过去的研究支持，并向既定的研究人员都提供了代表与他们正在进行的研究有很大差别的项目的研究人员。该计划的目的是提供足够的资金，以生成酒精研究项目的试点数据，这些数据可用于支持研究赠款的应用。详细的审查过程包括对建议的内部征集，适当的中心教师的参与和建议，以及内部和外部审查，以选择最高质量的研究。试点计划还利用了NC临床和转化研究联盟（NIH临床翻译，科学奖）的资金，该资金将使ARC的资金与杰出的建议相匹配。以前由我们的中心赠款资助的飞行员项目为UNC研究人员提供了新的NIH资金。这个过程将新的人和新想法带入了中心，更新了其活力和创新，并帮助我们保持了该领域的最前沿。作为本提案的一部分，该弧线包括两个试点项目（项目16和17）。这两个项目都与我们的酒精发病机理的主题很好地融合。项目16（Ramon Bataller，PI）将测试P90RSK是否介导酒精性肝炎（AH）中的肝损伤和炎症。他的小组将对来自患者的肝样本进行翻译研究，其中P90RSK表达和激活将与疾病的严重程度确定并相关。接下来，他们将研究具有实验性AH的小鼠的P90RSK抑制是否会减轻肝损伤和炎症。项目17（PI唐纳德·拉斯尔（Donald Lysle，pi）将研究Interteukin-1 | 3（IL-1（3）在乙醇暴饮暴食中研究人员为大型研究赠款而言重要的初步发现支持了我们的弧线的长期增长和成功。