Mentoring in patient-oriented atrial fibrillation and cardiovascular research

指导以患者为中心的心房颤动和心血管研究

基本信息

批准号：
10414916
负责人：
Alvaro Alonso
金额：
$ 11.85万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10414916
关键词：
Address Area Arrhythmia Atrial Fibrillation Award Blood specimen Cardiac Catheterization Procedures Cardiac ablation Cardiology Cardiovascular Diseases Cardiovascular system Characteristics Classification Clinical Clinical Data Clinical Investigator Clinical Management Cluster Analysis Coronary Arteriosclerosis Data Development Doctor of Philosophy Enrollment Environment Epidemiology Etiology Fellowship Program Functional disorder Funding Genomics Goals Grant Health Disparities Research Heart Atrium Heart failure Heterogeneity Hospitals Image Incidence Individual Ischemic Stroke Knowledge Lead Life Style Literature Machine Learning Master of Public Health Mentors Methodology Multiomic Data National Heart, Lung, and Blood Institute Outcome Participant Patients Pattern Phenotype Population Prevention Prevention strategy Principal Investigator Process Public Health Public Health Schools Research Research Activity Research Personnel Research Project Grants Resources Risk Risk Factors Stratification Stroke Survival Analysis Techniques Technology Therapeutic Therapeutic Intervention Time Training Training Programs Universities Work base biobank candidate selection cardiovascular disorder epidemiology cardiovascular health career development clinical prognosis graduate student high risk population innovation interest lifestyle factors medical schools metabolomics mortality multidisciplinary multiple omics novel novel therapeutic intervention patient oriented patient oriented research patient prognosis patient registry patient subsets prevent preventive intervention programs prospective protein biomarkers skill acquisition skills sociodemographic factors sociodemographics transcriptomics trend

项目摘要

PROJECT SUMMARY This application will provide the Principal Investigator, Dr. Alvaro Alonso, with protected time and other support to (1) accelerate a successful record of mentoring junior clinical investigators and graduate students engaged in patient-oriented cardiovascular research; (2) obtain additional training in omics, machine learning, and mentoring best-practices; and (3) advance Dr. Alonso's ongoing research on the risk factors and mechanisms contributing to the development of atrial fibrillation (AF). Mentoring activities will build upon the ongoing involvement of Dr. Alonso in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health disparities, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in epidemiology at the Rollins School of Public Health. Training will focus on cutting-edge methodological areas in rapid development, including integration of omic technologies and machine learning in patient-oriented research, as well as acquisition of skills in academic, research, and clinical mentoring. Finally, this award will support a research project that extends Dr. Alonso's ongoing work on understanding the factors influencing the development of the AF substrate, understanding AF pathophysiology, and preventing AF-related outcomes. The specific aims of this research are: (1) to identify novel AF phenotypes (phenogroups) using extensive clinical and multi-omic data (“phenomapping”), (2) to discover specific risk factors for the different AF phenogroups, and (3) to determine associations of AF phenogroups with selected endpoints (stroke, heart failure, mortality). These research aims will be carried out in the context of the Emory Cardiovascular Biobank, an ongoing prospective registry of patients undergoing cardiac catheterization in three Emory-affiliated hospitals currently including approximately 7,000 unique individuals with detailed phenotyping, clinical outcomes, and multi-omic markers. In summary, the activities proposed in this application will favorably impact Dr. Alonso's capabilities to conduct cutting-edge and innovative patient-oriented research on cardiovascular prevention and his ability to perform as a highly qualified mentor for junior clinicians pursuing research on clinical cardiovascular epidemiology and prevention.

项目概要该应用程序将为首席研究员阿尔瓦罗·阿隆索博士提供受保护的时间和其他支持 (1) 加速指导初级临床研究人员和研究生的成功记录以患者为导向的心血管研究；(2) 获得组学、机器学习方面的额外培训，以及指导最佳实践；(3) 推进阿隆索博士正在进行的风险因素和机制研究促进心房颤动 (AF) 发展的指导活动将建立在正在进行的基础上。阿隆索博士参与了埃默里大学的多个培训项目，包括 NHLBI 资助的项目关于心血管健康差异的多学科 T32 培训补助金，研究方向心脏病学医学院的奖学金计划以及公共卫生硕士和博士课程罗林斯公共卫生学院的流行病学培训将重点关注前沿方法学领域。快速发展，包括组学技术和机器学习在以患者为导向的领域的整合研究，以及获得学术、研究和临床指导方面的技能。支持一个研究项目，该项目扩展了阿隆索博士正在进行的了解影响因素的工作房颤基质的发展，了解房颤病理生理学，并预防房颤相关的结果。本研究的具体目的是：（1）利用广泛的方法来识别新的 AF 表型（表型组）临床和多组学数据（“表型分析”），(2) 发现不同 AF 的特定危险因素表型组，以及 (3) 确定 AF 表型组与选定终点（中风、心脏这些研究目标将在埃默里心血管生物库的背景下进行，正在进行的对在埃默里大学附属的三个中心接受心导管插入术的患者进行的前瞻性登记目前包括约 7,000 名具有详细表型的独特个体、临床医院总之，本申请中提出的活动将产生有利的影响。阿隆索博士有能力开展以患者为中心的尖端、创新的心血管研究预防以及他作为初级研究的高素质导师的能力临床心血管流行病学与预防。