Mentoring in patient-oriented atrial fibrillation and cardiovascular research

指导以患者为中心的心房颤动和心血管研究

基本信息

批准号：
10657434
负责人：
Alvaro Alonso
金额：
$ 11.85万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10657434
关键词：
Acceleration Address Area Arrhythmia Atrial Fibrillation Award Blood specimen Cardiac Catheterization Procedures Cardiac ablation Cardiology Cardiovascular Diseases Cardiovascular system Categories Characteristics Classification Clinical Clinical Data Clinical Investigator Clinical Management Cluster Analysis Coronary Arteriosclerosis Data Development Doctor of Philosophy Enrollment Environment Epidemiology Etiology Fellowship Program Functional disorder Funding Genomics Goals Grant Heart Atrium Heart failure Heterogeneity Hospitals Image Incidence Individual Ischemic Stroke Knowledge Life Style Literature Machine Learning Master of Public Health Mentors Methodology Multiomic Data National Heart, Lung, and Blood Institute Outcome Participant Patients Pattern Phenotype Population Prevention Prevention strategy Principal Investigator Process Public Health Public Health Schools Qualifying Research Research Activity Research Personnel Research Project Grants Resources Risk Risk Factors Stratification Stroke Survival Analysis Techniques Technology Therapeutic Therapeutic Intervention Time Training Training Programs Universities Work biobank candidate selection cardiovascular disorder epidemiology cardiovascular health career development clinical prognosis graduate student health disparity high risk population innovation interest medical schools metabolomics mortality multidisciplinary multiple omics novel novel therapeutic intervention participant enrollment patient oriented patient oriented research patient prognosis patient registry patient subsets prevent preventive intervention programs prospective protein biomarkers risk selection skill acquisition sociodemographic factors sociodemographics student participation transcriptomics trend

项目摘要

PROJECT SUMMARY This application will provide the Principal Investigator, Dr. Alvaro Alonso, with protected time and other support to (1) accelerate a successful record of mentoring junior clinical investigators and graduate students engaged in patient-oriented cardiovascular research; (2) obtain additional training in omics, machine learning, and mentoring best-practices; and (3) advance Dr. Alonso's ongoing research on the risk factors and mechanisms contributing to the development of atrial fibrillation (AF). Mentoring activities will build upon the ongoing involvement of Dr. Alonso in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health disparities, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in epidemiology at the Rollins School of Public Health. Training will focus on cutting-edge methodological areas in rapid development, including integration of omic technologies and machine learning in patient-oriented research, as well as acquisition of skills in academic, research, and clinical mentoring. Finally, this award will support a research project that extends Dr. Alonso's ongoing work on understanding the factors influencing the development of the AF substrate, understanding AF pathophysiology, and preventing AF-related outcomes. The specific aims of this research are: (1) to identify novel AF phenotypes (phenogroups) using extensive clinical and multi-omic data (“phenomapping”), (2) to discover specific risk factors for the different AF phenogroups, and (3) to determine associations of AF phenogroups with selected endpoints (stroke, heart failure, mortality). These research aims will be carried out in the context of the Emory Cardiovascular Biobank, an ongoing prospective registry of patients undergoing cardiac catheterization in three Emory-affiliated hospitals currently including approximately 7,000 unique individuals with detailed phenotyping, clinical outcomes, and multi-omic markers. In summary, the activities proposed in this application will favorably impact Dr. Alonso's capabilities to conduct cutting-edge and innovative patient-oriented research on cardiovascular prevention and his ability to perform as a highly qualified mentor for junior clinicians pursuing research on clinical cardiovascular epidemiology and prevention.

项目摘要该申请将为主要研究人员Alvaro Alonso博士提供受保护的时间和其他支持（1）加速了精神上的初级临床研究人员和研究生的成功记录在面向患者的心血管研究中；（2）获得OMIC，机器学习和指导最佳实践；（3）推进阿隆索博士对风险因素和机制的持续研究有助于房颤的发展（AF）。指导活动将基于持续的阿隆索博士参与埃默里大学的多项培训计划，包括NHLBI资助心血管健康差异的多学科T32培训补助金，研究轨道心脏病学医学院的奖学金计划，以及公共卫生和博士学位硕士课程罗林斯公共卫生学院的流行病学。培训将重点放在尖端的方法论领域快速发展，包括在以患者为导向的OMIC Technologies和机器学习的集成研究，以及学术，研究和临床心理方面的技能。最后，这个奖项将支持一个扩展Alonso博士正在进行的了解因素影响因素的研究项目 AF底物的发展，了解AF病理生理学并预防与AF相关的结果。这项研究的具体目的是：（1）使用广泛的临床和多族数据（“现象”），（2）发现不同AF的特定风险因素现象群，（3）确定AF现象与选定端点的关联（卒中，心脏失败，死亡率）。这些研究目标将在埃默里心血管生物库的背景下进行持续的前瞻性注册表，即在三个埃默里附上进行心脏导管插入术的患者目前，医院包括大约7,000名独特的人，具有详细的表型，临床结果和多摩尼克标记。总而言之，本申请中提出的活动将有利地影响阿隆索博士对心血管进行最先进和创新的以患者为导向的研究预防及其作为初级临床医生的高素质精神的能力，从事研究临床心血管流行病学和预防。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Impact of Cocaine Use and the Obesity Paradox in Patients With Heart Failure With Reduced Ejection Fraction Due to Non-ischemic Cardiomyopathy.

DOI：
10.7759/cureus.40298
发表时间：
2023-06
期刊：
Cureus
影响因子：
0
作者：
Akinlonu AA;Alonso A;Mene-Afejuku TO;Lopez P;Kansara T;Ola O;Mushiyev S;Pekler G
通讯作者：
Pekler G

Associations of anger, vital exhaustion, anti-depressant use, and poor social ties with incident atrial fibrillation: The Atherosclerosis Risk in Communities Study.

DOI：
10.1177/2047487319897163
发表时间：
2021-05-22
期刊：
European journal of preventive cardiology
影响因子：
8.3
作者：
Garg PK;Claxton JS;Soliman EZ;Chen LY;Lewis TT;Mosley T;Alonso A
通讯作者：
Alonso A

Thirty-Year Trends in the Incidence of Atrial Fibrillation: The ARIC Study.

DOI：
10.1161/jaha.121.023583
发表时间：
2022-04-19
期刊：
JOURNAL OF THE AMERICAN HEART ASSOCIATION
影响因子：
5.4
作者：
Ghelani, Kunali P.;Chen, Lin Yee;Norby, Faye L.;Soliman, Elsayed Z.;Koton, Silvia;Alonso, Alvaro
通讯作者：
Alonso, Alvaro

Association of socioeconomic status with arterial stiffness in older African American and White adults: The ARIC study cohort.

DOI：
10.1016/j.ajpc.2023.100469
发表时间：
2023-03
期刊：
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
影响因子：
4.1
作者：
Spikes, Telisa A;Alam, Aniqa B;Lewis, Tene T;Gwen Windham, B;Kucharska-Newton, Anna;Alonso, Alvaro
通讯作者：
Alonso, Alvaro

Differences in incident and recurrent myocardial infarction among White and Black individuals aged 35 to 84: Findings from the ARIC community surveillance study.