South Texas Alzheimer's Disease Center Imaging Core

南德克萨斯阿尔茨海默病中心影像核心

基本信息

批准号：
10472660
负责人：
PETER Thornton FOX
金额：
$ 29.21万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10472660
关键词：
Agreement Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Amyloid Animals Architecture Archives Arts Autopsy Biochemistry Biomedical Research Blood Chemical Analysis Brain Capital Clinical Clinical Trials Collaborations Communities Computers Consult Custom Cyclic GMP Cyclotrons Data Degree program Development Diagnostic radiologic examination Doctor of Philosophy Doctor&apos s Degree Equipment Etiology Excision FDA approved Faculty Faculty Recruitment Fostering Foxes Functional Magnetic Resonance Imaging Generations Genetic Goals Grant High Performance Computing Hispanic Populations Home Human Image Image Analysis Infrastructure Institutes International Ions Isotopes K-Series Research Career Programs Laboratories MRI Scans Machine Learning Magnetic Resonance Imaging Measures Medical Medical Imaging Metabolism Methods Mission Morphologic artifacts Motion Neurosciences Performance Physicians Physiologic pulse Play Population Positron-Emission Tomography Postdoctoral Fellow Production Protocols documentation Psychometrics Publications Quality Control RF coil Radiochemistry Radiology Specialty Radiopharmaceuticals Research Research Institute Research Training Resources Robotics Role Scanning Science Scientist Services Site South Texas Standardization Statistical Data Interpretation Stimulus Structure Supervision System Texas Training Training Programs Training Support Transcranial magnetic stimulation Validation Work base brain magnetic resonance imaging burden of illness clinical care clinical center cluster computing data management data sharing education research experience faculty mentor genetic pedigree graduate student graph theory hemodynamics human imaging image archival system image guided imaging facilities imaging modality imaging program informatics infrastructure instrument instrumentation magnetic resonance spectroscopic imaging multi-site trial multimodality multiple omics network models neuroimaging neuropathology novel post-doctoral training programs protocol development receptor density recruit research facility response spectroscopic imaging statistical learning statistics tau Proteins trial design virtual web interface

项目摘要

The Imaging Core (IC) highlights the strengths of the South Texas Alzheimer Center (STAC), which has a critical mass of infrastructure, imaging expertise, and training programs. It is comprised of the Research Imaging Institute (RII), the Department of Radiology and the Radiological Sciences Graduate Program (RSGP). The RII is a research unit that has supported biomedical research in South Texas for 30 years, including numerous international collaborations. PI Fox has >100 publications/ multiple grants with Genetics and Multiomics core PI, Blangero at UTRGV. The RII is housed in the same building as the Clinical Core (CC) and Population Neuroscience Core at UTHSA and includes: magnetic resonance imaging and spectroscopy (MR/MRSI) for humans (3-T) and animals (7-T, 12-T); positron-emission tomography (PET) for humans and animals; two medical cyclotrons for PET-isotope production; and, radio-pharmaceutical production facilities, including an FDA-approved (ANDA & IND) cGMP commercial-production facility. Ancillary capabilities include in-scanner performance-control systems (stimulus delivery and response recording); image-guided, robotic transcranial magnetic stimulation (irTMS). RII faculty provide expertise in image acquisition (including radiochemistry and pulse-sequence editing), image preprocessing, and sophisticated analysis, including machine learning, AI. Image archiving, analysis and sharing (XNAT) capabilities are provided by virtual computers, a new on-site high-performance compute cluster (GENIE) and ready access to the Texas Advanced Computing Center. The Department of Radiology provides neuroradiologic expertise (including a fluoroscopic suite dedicated to research LP) and 2 additional 3T MRI and a PET/CT scanner, also in the same building as the CC. The STAC is a site for several clinical trials (AHEAD 3-45, markVCID, GOBS, TARCC) demonstrating ability to acquire high quality MRI (with DTI, CVR, fcMRI), amyloid, tau and FDG PET. We routinely obtain ADNI-3 protocol MRI as part of clinical care and have implemented the protocol across 5 MRI scanners (3 at UTHSA and 1 each at Laredo and Harlingen CC sites). We will obtain these MRI scans on all CC enrollees, annually, and will also obtain amyloid (PIB) and tau (T807, flutaucipir) PET to categorize enrollees using A/T/N criteria. We have recruited a neuroradiologist, radiochemist and computational analyst in the past year. We have implemented a post-mortem whole brain MRI protocol (with Neuropathology core). IC faculty are leaders in multimodal MRI, functional MR and in applying and developing novel image analysis methods to answer questions relevant to ADRD; they are leading MRI harmonization/analyses within CHARGE, iSHARE consortia and in SPRINT-MIND. The RSGP supports the STAC REC by overseeing 3 doctoral degree programs directed by IC core leaders: Neuroscience Imaging (P. Fox), Human Imaging (G. Clarke), and, Diagnostic Radiology (M. Habes) and partners with an R25 Medical Scientist Training Program (MSTP, PI Cavazos who also leads the STAC REC) to train MD/PhD scientists.

成像核（IC）强调了南德克萨斯州阿尔茨海默氏症中心（STAC）的优势具有大量的基础设施，成像专业知识和培训计划。它由研究组成成像学院（RII），放射学和放射科学系研究生计划（RSGP）。 RII是一个研究部门，在南德克萨斯州支持生物医学研究已有30年了，包括许多国际合作。 Pi Fox拥有> 100个出版物/遗传学的多个赠款和多组学核心PI，UTRGV的Blangero。 RII与临床核心相同的建筑物中（CC）和人群神经科学核心在UTHSA上，包括：磁共振成像和人类（3-T）和动物（7-T，12-T）的光谱（MR/MRSI）；正电子发射断层扫描（PET）人类和动物；两种用于宠物异位生产的医学环状基因；以及无线电制作生产设施，包括FDA批准的（ANDA和IND）CGMP商业生产设施。辅助功能包括扫描仪性能控制系统（刺激传递和响应记录）；图像引导，机器人经颅磁刺激（IRTMS）。 RII教师提供图像获取方面的专业知识（包括放射化学和脉搏序列编辑），图像预处理和复杂分析，包括机器学习，AI。图像归档，分析和共享（XNAT）功能由虚拟提供计算机，一种新的现场高性能计算集群（Genie），并可以访问德克萨斯州高级计算中心。放射学系提供了神经放射学专业知识（包括荧光镜套件专用于研究LP）和另外2个3T MRI和一个PET/CT扫描仪，也在建造为CC。 STAC是几个临床试验的地点（3-45，Markvcid，GOBS，TARCC）表现出获得高质量MRI（使用DTI，CVR，FCMRI），淀粉样蛋白，TAU和FDG PET的能力。我们作为临床护理的一部分，常规获取ADNI-3方案MRI，并在5 MRI中实施了该协议扫描仪（在Uthsa中有3个，Laredo和Harlingen CC站点各有1个）。我们将在所有人上获得这些MRI扫描每年的CC参与者，还将获得淀粉样蛋白（PIB）和Tau（T807，flutaucipir）PET进行分类使用A/T/N标准的参与者。我们已经招募了一名神经放射学家，放射药师和计算分析师过去一年。我们已经实施了验尸后的整个大脑MRI方案（具有神经病理核心）。我知道了教师是多模式MRI，功能性MR以及应用和开发新型图像分析的领导者回答与ADRD相关的问题的方法；他们领导MRI协调/分析充电，Ishare Consortia和Sprint-Mind。 RSGP通过监督3 IC核心领导者指导的博士学位课程：神经科学成像（P. Fox），人类成像（G. Clarke），以及R25医学科学家培训计划的诊断放射学（M. Habes）和合作伙伴（MSTP，PI Cavazos也带领STAC REC）培训MD/PhD科学家。