South Texas Alzheimer's Disease Center Imaging Core

南德克萨斯阿尔茨海默病中心影像核心

基本信息

批准号：
10472660
负责人：
PETER Thornton FOX
金额：
$ 29.21万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10472660
关键词：
Agreement Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Amyloid Animals Architecture Archives Arts Autopsy Biochemistry Biomedical Research Blood Chemical Analysis Brain Capital Clinical Clinical Trials Collaborations Communities Computers Consult Custom Cyclic GMP Cyclotrons Data Degree program Development Diagnostic radiologic examination Doctor of Philosophy Doctor&apos s Degree Equipment Etiology Excision FDA approved Faculty Faculty Recruitment Fostering Foxes Functional Magnetic Resonance Imaging Generations Genetic Goals Grant High Performance Computing Hispanic Populations Home Human Image Image Analysis Infrastructure Institutes International Ions Isotopes K-Series Research Career Programs Laboratories MRI Scans Machine Learning Magnetic Resonance Imaging Measures Medical Medical Imaging Metabolism Methods Mission Morphologic artifacts Motion Neurosciences Performance Physicians Physiologic pulse Play Population Positron-Emission Tomography Postdoctoral Fellow Production Protocols documentation Psychometrics Publications Quality Control RF coil Radiochemistry Radiology Specialty Radiopharmaceuticals Research Research Institute Research Training Resources Robotics Role Scanning Science Scientist Services Site South Texas Standardization Statistical Data Interpretation Stimulus Structure Supervision System Texas Training Training Programs Training Support Transcranial magnetic stimulation Validation Work base brain magnetic resonance imaging burden of illness clinical care clinical center cluster computing data management data sharing education research experience faculty mentor genetic pedigree graduate student graph theory hemodynamics human imaging image archival system image guided imaging facilities imaging modality imaging program informatics infrastructure instrument instrumentation magnetic resonance spectroscopic imaging multi-site trial multimodality multiple omics network models neuroimaging neuropathology novel post-doctoral training programs protocol development receptor density recruit research facility response spectroscopic imaging statistical learning statistics tau Proteins trial design virtual web interface

项目摘要

The Imaging Core (IC) highlights the strengths of the South Texas Alzheimer Center (STAC), which has a critical mass of infrastructure, imaging expertise, and training programs. It is comprised of the Research Imaging Institute (RII), the Department of Radiology and the Radiological Sciences Graduate Program (RSGP). The RII is a research unit that has supported biomedical research in South Texas for 30 years, including numerous international collaborations. PI Fox has >100 publications/ multiple grants with Genetics and Multiomics core PI, Blangero at UTRGV. The RII is housed in the same building as the Clinical Core (CC) and Population Neuroscience Core at UTHSA and includes: magnetic resonance imaging and spectroscopy (MR/MRSI) for humans (3-T) and animals (7-T, 12-T); positron-emission tomography (PET) for humans and animals; two medical cyclotrons for PET-isotope production; and, radio-pharmaceutical production facilities, including an FDA-approved (ANDA & IND) cGMP commercial-production facility. Ancillary capabilities include in-scanner performance-control systems (stimulus delivery and response recording); image-guided, robotic transcranial magnetic stimulation (irTMS). RII faculty provide expertise in image acquisition (including radiochemistry and pulse-sequence editing), image preprocessing, and sophisticated analysis, including machine learning, AI. Image archiving, analysis and sharing (XNAT) capabilities are provided by virtual computers, a new on-site high-performance compute cluster (GENIE) and ready access to the Texas Advanced Computing Center. The Department of Radiology provides neuroradiologic expertise (including a fluoroscopic suite dedicated to research LP) and 2 additional 3T MRI and a PET/CT scanner, also in the same building as the CC. The STAC is a site for several clinical trials (AHEAD 3-45, markVCID, GOBS, TARCC) demonstrating ability to acquire high quality MRI (with DTI, CVR, fcMRI), amyloid, tau and FDG PET. We routinely obtain ADNI-3 protocol MRI as part of clinical care and have implemented the protocol across 5 MRI scanners (3 at UTHSA and 1 each at Laredo and Harlingen CC sites). We will obtain these MRI scans on all CC enrollees, annually, and will also obtain amyloid (PIB) and tau (T807, flutaucipir) PET to categorize enrollees using A/T/N criteria. We have recruited a neuroradiologist, radiochemist and computational analyst in the past year. We have implemented a post-mortem whole brain MRI protocol (with Neuropathology core). IC faculty are leaders in multimodal MRI, functional MR and in applying and developing novel image analysis methods to answer questions relevant to ADRD; they are leading MRI harmonization/analyses within CHARGE, iSHARE consortia and in SPRINT-MIND. The RSGP supports the STAC REC by overseeing 3 doctoral degree programs directed by IC core leaders: Neuroscience Imaging (P. Fox), Human Imaging (G. Clarke), and, Diagnostic Radiology (M. Habes) and partners with an R25 Medical Scientist Training Program (MSTP, PI Cavazos who also leads the STAC REC) to train MD/PhD scientists.

成像核心 (IC) 凸显了南德克萨斯阿尔茨海默病中心 (STAC) 的优势，该中心拥有大量基础设施、成像专业知识和培训计划。它由研究组成影像研究所 (RII)、放射学系和放射科学研究生项目（RSGP）。 RII 是一个研究单位，30 年来一直支持德克萨斯州南部的生物医学研究，包括众多的国际合作。 PI Fox 拥有超过 100 篇出版物/多项遗传学资助以及 UTRGV 的 Multiomics 核心 PI Blangero。 RII 与临床核心位于同一栋大楼内 (CC) 和 UTHSA 的人口神经科学核心，包括：磁共振成像和人类 (3-T) 和动物 (7-T、12-T) 的光谱 (MR/MRSI)；正电子发射断层扫描 (PET) 人类和动物；两台用于 PET 同位素生产的医用回旋加速器；以及放射性药物生产设施，包括 FDA 批准的（ANDA 和 IND）cGMP 商业生产设施。辅助能力包括扫描仪内性能控制系统（刺激传递和反应记录）；图像引导，机器人经颅磁刺激（irTMS）。 RII 教师提供图像采集方面的专业知识（包括放射化学和脉冲序列编辑）、图像预处理和复杂的分析，包括机器学习，人工智能。图像归档、分析和共享（XNAT）功能由虚拟化提供计算机、新的现场高性能计算集群 (GENIE) 以及随时访问德克萨斯州先进计算中心。放射科提供神经放射学专业知识（包括专用于研究 LP 的荧光镜套件）和 2 个额外的 3T MRI 和 PET/CT 扫描仪，也在同一房间内大楼作为CC。 STAC 是多个临床试验的场所（AHEAD 3-45、markVCID、GOBS、TARCC）展示了获取高质量 MRI（DTI、CVR、fcMRI）、淀粉样蛋白、tau 和 FDG PET 的能力。我们作为临床护理的一部分，定期获得 ADNI-3 协议 MRI，并已在 5 个 MRI 中实施该协议扫描仪（UTHSA 3 台，拉雷多和哈林根 CC 站点各 1 台）。我们将对所有患者进行 MRI 扫描 CC 参与者每年都会获得淀粉样蛋白 (PIB) 和 tau（T807、flutaucipir）PET 进行分类使用 A/T/N 标准的登记者。我们招募了一名神经放射学家、放射化学家和计算分析师过去的一年。我们实施了尸检全脑 MRI 方案（以神经病理学为核心）。我知道了教师是多模态 MRI、功能 MR 以及应用和开发新型图像分析领域的领导者回答与 ADRD 相关问题的方法；他们正在领导 MRI 协调/分析 CHARGE、iSHARE 联盟和 SPRINT-MIND。 RSGP 通过监督 3 项来支持 STAC REC IC核心领导者指导的博士学位课程：神经科学成像（P. Fox）、人类成像（G. Fox） Clarke）和诊断放射学（M. Habes）并与 R25 医学科学家培训计划合作（MSTP、PI Cavazos，同时领导 STAC REC）培训医学博士/博士科学家。