CAP - Consortium to Alleviate PTSD - STVHCS Neuroimaging Core

CAP - 减轻 PTSD 联盟 - STVHCS 神经影像核心

• 批准号: 8770323
• 负责人: PETER Thornton FOX
• 金额: --
• 依托单位: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8770323
• 关键词: Address; Advisory Committees; Alcohol or Other Drugs use; Animals; Biological Markers; Biological Models; Characteristics; Clinical Trials; Cognitive Therapy; Communication; Data; Diagnosis; Diagnostic; Diagnostic Sensitivity; Disclosure; Electronics; Employee Strikes; Ensure; Epidemiology; Equilibrium; Etiology; Evaluation; Exposure to; Fostering; Foundations; Foxes; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Genomics; Goals; Government; Guidelines; Headache; Image; Image Analysis; Impairment; Individual; Institutes; Institution; Intervention; Ketamine; Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mental Depression; Mental Health; Meta-Analysis; Methods; Military Personnel; Modeling; Neurobiology; Neurocognitive; Pain; Pathology; Personal Satisfaction; Persons; Pharmacotherapy; Positioning Attribute; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Prevention; Prevention strategy; Preventive; Principal Investigator; Printing; Procedures; Process; Productivity; Proteomics; Protocols documentation; Psychometrics; Publications; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Review Committee; Role; Services; Site; Sleep disturbances; Sleeplessness; Stress; Structure; Suicide; System; Teleconferences; Tracer; Training; Veterans; Work; base; behavioral health; combat; cost; data acquisition; design; imaging modality; improved; interest; meetings; member; multidisciplinary; neuroimaging; neurophysiology; novel; organizational structure; outcome forecast; physical conditioning; post-traumatic stress; prevent; prognostic; quality assurance; research study; response; success; tomography; treatment response

Neuroimaging Core The Neuroimaging Core builds upon a strong foundation developed over the past four years as a STRONG STAR core. Dr. Fox is currently Director of the STRONG STAR Neuroimaging Core; he will continue in this role for the STRONG STAR-CAP, being joined by Dr. Krystal as Co-Director. The overall objective of the Neuroimaging Core is to foster the use of advanced neuroimaging methods in the study of PTSD and related conditions for the purposes of (1) investigating the underlying pathology (using structural imaging) and pathophysiology (using functional imaging); (2) assessing and enhancing the diagnostic sensitivity of imaging methods; (3) investigating the neurophysiology of treatment response (image-based response assessment); and (4) ensuring comparability of imaging data acquisition and pre-processing between sites. Neuroimaging methods utilized include structural and functional magnetic resonance imaging (MRI and fMRI), magnetic resonance spectroscopy (MRS), and position emission tomography (PET). These methods are used in the context of extensive neurocognitive assessments focused on evaluation of PTSD-related impairments, with psychometric scores being used as probes for voxel-wise and region-of-interest-based analyses. The Neuroimaging Core provides standardized core image-acquisition and image-analysis protocols (both structural and functional), as well as developing project-specific neuroimaging probes. In the ongoing STRONG STAR Consortium, neuroimaging imaging assessments focused on modeling the system-level effects of PTSD (e.g., Ramage et al., 2012) and characterizing the mechanisms of action of cognitive and behavioral therapy. In the current proposal, emphasis is placed on the mechanisms of action of Prolonged Exposure (PE; project 1), on pharmacotherapy (ketamine; Project 1) and on insomnia (Project 7). Previously based solely at UTHSCSA's Research Imaging Institute, the Neuroimaging Core now incorporates a second world-class neuroimaging facility, i.e., that at Yale. In doing so, the Neuroimaging Core builds upon an ongoing collaborative relationship with Yale, focused on high-field, small-animal imaging. Image-analysis capabilities at both core components are outstanding and complementary, with the Research Imaging Institute having exceptional strengths in meta- analysis and system-level modeling construction and with Yale having exceptional strengths in analysis of pharmacologic interventions and tracer-based imaging methods.

神经影像核心 神经影像核心建立在过去四年作为强大的 星核。 Fox 博士现任 STRONG STAR 神经影像核心主任；他将继续在这方面 Krystal 博士作为联合主任加入了 STRONG STAR-CAP 的角色。总体目标 神经影像学核心旨在促进先进神经影像学方法在 PTSD 及相关研究中的应用 用于 (1) 研究潜在病理学（使用结构成像）的条件和 病理生理学（使用功能成像）； (2)评估和提​​高影像诊断的敏感性 方法; (3) 研究治疗反应的神经生理学（基于图像的反应评估）；和 (4)确保站点之间成像数据采集和预处理的可比性。神经影像学 使用的方法包括结构和功能磁共振成像（MRI 和 fMRI）、磁 共振光谱 (MRS) 和位置发射断层扫描 (PET)。这些方法用于 广泛的神经认知评估的背景侧重于评估 PTSD 相关的损伤， 心理测量分数被用作体素和基于感兴趣区域的分析的探针。这 Neuroimaging Core 提供标准化的核心图像采集和图像分析协议（结构 和功能），以及开发项目特定的神经影像探针。在正在进行的STRONG STAR 联盟的神经影像学评估重点是对 PTSD 的系统级影响进行建模（例如， Ramage 等人，2012）并描述了认知和行为疗法的作用机制。在 目前的提案，重点放在长期暴露（PE；项目 1）的作用机制上， 药物治疗（氯胺酮；项目 1）和失眠（项目 7）。以前仅位于 UTHSCSA 影像研究所的神经影像核心现已纳入第二个世界级的神经影像 设施，即耶鲁大学的设施。在此过程中，神经影像核心建立在持续的合作关系之上 与耶鲁大学合作，专注于高场小动物成像。两个核心组件的图像分析功能 是杰出且互补的，影像研究所在元- 分析和系统级建模构建，耶鲁大学在分析方面具有非凡的优势 药物干预和基于示踪剂的成像方法。