Childhood adversity and Cardiovascular Health among Puerto Rican youth.

波多黎各青年的童年逆境和心血管健康。

基本信息

批准号：
10001194
负责人：
Shakira Franco Suglia
金额：
$ 6.91万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001194
关键词：
13 year old Academy Acculturation Address Adolescence Adult Adverse event Advisory Committees Affect Age Alcohol consumption Alcohol or Other Drugs use American Behavior Behavioral Risk Factor Surveillance System Blood Pressure Cardiovascular Diseases Cardiovascular system Child Child Abuse and Neglect Child Mental Disorders Childhood Coping Behavior Cross-Sectional Studies Data Data Collection Development Diet Disease Early Intervention Economics Ethnic group Event Exposure to Feasibility Studies Glycosylated hemoglobin A Goals Health Healthy People 2020 High Density Lipoprotein Cholesterol High Prevalence Hispanics Hypertension Imprisonment Inflammation Interview Knowledge Latino Life Life Cycle Stages Longitudinal cohort Measures Mediating Mediator of activation protein Mental Health Methodology Minority Groups Modeling Myocardial Infarction Myocardial Ischemia National Heart, Lung, and Blood Institute New York Obesity Outcome Parents Participant Patient Self-Report Pediatrics Physical activity Pilot Projects Play Population Population Study Poverty Practice Guidelines Prevention Psyche structure Psychopathology Puerto Rican Puerto Rico Reporting Research Risk Factors Role Sampling Sleep Social support Strategic Planning Stress Stroke Subgroup Substance Use Disorder Symptoms Tobacco use United States Woman Youth adolescent health adverse childhood events base cardiovascular disorder prevention cardiovascular health cardiovascular risk factor childhood adversity design disadvantaged population early adolescence ethnic minority population experience follow-up health assessment health disparity health service use hypercholesterolemia interest low socioeconomic status mental development modifiable risk population based preservation prospective protective factors racial and ethnic recruit retention rate screening social social culture social health determinants therapy development young adult

项目摘要

Childhood Adversity and Cardiovascular Health among Puerto Rican youth Shakira F Suglia Latinos, the largest and fastest growing ethnic minority group in the United States, are vulnerable to the health related consequences of living in poverty; 32% are obese and 22% have hypertension. Puerto Rican women have the highest rate of obesity, hypertension and hypercholesterolemia than any other Latino subgroup. Recent research has demonstrated that childhood adversity is associated with cardiovascular disease in adulthood. However, adapting and coping behaviors that prime those exposed to adversity in childhood to develop poor cardiovascular outcomes remain largely unexplored. Understanding how childhood adversity affects obesity, blood pressure and inflammation as well as understanding the potential modifiers and mediators of these associations prior to the development of cardiovascular disease directly addresses the strategic plan of NHLBI to promote early intervention before symptoms of disease appear so as to preserve normal function as long as possible. The goal of this proposal is to conduct a cardiovascular health assessment of 1,200 Puerto Rican young adults (ages 18-23) living in two different contexts: the South Bronx, NY and San Juan, Puerto Rico. The sample to be recruited is part of the Boricua Youth Study (BYS), a longitudinal (4 waves of data) population-based study that started collecting information when participants were 5 – 13 years old (compliance rate higher than 80% in the last completed assessment). In this unique sample of a homogeneous Latino subgroup (Puerto Ricans) in two contexts, we propose to examine: 1) the relation between childhood adversity (negative life events, parental incarceration, psychopathology and substance use, child maltreatment) and selected indicators of cardiovascular heath (obesity, blood pressure and systemic inflammation) in young adulthood; 2) the mediating effect of child mental and substance use disorders; and 3) the role played by socio-cultural factors, including context, social support, acculturation and use of health services. The research team has expertise in the study of social determinants of health, the effects of stress on health, as well as on adolescent health. Dr. Suglia (PI) has conducted a feasibility study (K01 HL103199) among BYS participants (N=103; 17-23 years old) in the South Bronx, NY and San Juan, Puerto Rico and has demonstrated good feasibility of cardiovascular health data collection as well as a high prevalence of cardiovascular health indicators of interest (obesity=30%; elevated blood pressure=22% and high systemic inflammation=23%). Extending the study to a larger sample (N=1,200) will allow higher precision in the estimate of cardiovascular measures, as well as the examination of mediators and modifiers of the childhood adversity and cardiovascular health association that can be targeted for prevention efforts among young Puerto Rican (and possibly other Latino) youth prior to the development of cardiovascular disease.

波多黎各青年的儿童逆境和心血管健康 Shakira F Suglia 拉丁美洲人是美国最大，增长最快的少数民族群体，容易受到健康的影响生活在贫困中的相关后果； 32％是肥胖，22％的患有高血压。波多黎各妇女肥胖，高血压和高胆固醇血症的率最高。最近的研究表明，儿童广告与心血管疾病有关成年。但是，适应和应对行为是童年接触广告的行为发展不良的心血管结局仍然很出乎意料。了解童年的广告影响肥胖，血压和炎症，并了解潜在的修饰剂和在发展心血管疾病之前，这些关联的调解人直接解决 NHLBI的战略计划在疾病外表症状之前促进早期干预以保存正常功能尽可能长。该建议的目的是进行心血管健康评估1,200名波多黎各年轻人（18-23岁）生活在两种不同的情况下：南布朗克斯纽约和圣胡安，波多黎各。要招募的样本是Boricua青年研究（BYS）的一部分，纵向（4个数据波）基于人群的研究，该研究在参与者是时开始收集信息 5 - 13岁（在最后完成评估中，合规率高于80％）。在这个独特的样本中在两种情况下，我们建议检查：1）关系：1）在童年冒险（负面的生活事件，父母事件，精神病理学和吸毒者使用，儿童虐待）和心血管热的选定指标（肥胖，血压和全身性炎症）成年； 2）儿童精神和药物使用障碍的中介作用； 3）社会文化因素所扮演的角色，包括背景，社会支持，适应和健康状况服务。研究小组在研究健康决定者的研究方面具有专业知识，压力对健康以及青春期健康。 Suglia博士（PI）进行了一项可行性研究（K01 HL103199）在BYS参与者（n = 103; 17-23岁），纽约州和圣胡安，波多黎各，有表现出心血管健康数据收集的良好可行性以及高流行率感兴趣的心血管健康指标（肥胖= 30％；血压升高= 22％和高度全身性炎症= 23％）。将研究扩展到更大的样本（n = 1,200）将允许更高的精度心血管测量值的估计以及童年的介体和修饰符的检查逆境和心血管卫生协会，可以针对年轻人的预防努力在发展心血管疾病之前，波多黎各人（可能是其他拉丁裔）青年。