Social Stress Epigenetics and Cardio-Metabolic Health Among Latinos

拉丁美洲人的社会压力表观遗传学和心脏代谢健康

• 批准号: 9764843
• 负责人: Shakira Franco Suglia
• 金额: $ 72.28万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-03 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764843
• 关键词: Acceleration; Acculturation; Address; Adult; Adverse event; Affect; Age; Aging; Ancillary Study; Biological; Biological Aging; Biological Assay; Biological Markers; Biological Process; Blood specimen; Cardiovascular Diseases; Chicago; Child Abuse; Childhood; Chronic; Chronic Disease; Chronology; Cities; Communities; Country; Cross-Sectional Studies; Cuban; DNA Methylation; Data; Development; Diabetes Mellitus; Dominican; Dose; Economics; Epigenetic Process; Ethnic group; Fibrinogen; Financial Hardship; Foundations; Glucocorticoid Receptor; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanics; Hypertension; Inflammation; Intervention; Latino; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Methods; Methylation; Mexican; Minority Groups; NR3C1 gene; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Policies; Poverty; Process; Puerto Rican; Receptor Gene; Research; Resource Allocation; Risk; Sampling; Shapes; Site; Skin; Social Network; Social support; Stress; Time; United States; Woman; Work; base; cardiometabolism; cardiovascular disorder risk; cohort; ethnic diversity; ethnic minority population; experience; genome wide methylation; genome-wide; health disparity; men; mortality; novel; racial and ethnic; racial diversity; rate of change; response; social; social stress; socioeconomics; stressor; tool

Latinos, the largest ethnic minority group in the United States, have a high prevalence of hypertension, diabetes and obesity and also experience higher rates of poverty and social stressors in both childhood and adulthood compared to other racial/ethnic groups. There is extensive evidence that economic and social stressors shape the development of cardiometabolic health. However, it is largely unknown how these stressors affect biological processes, particularly at the cellular level. One novel method to evaluate possible mechanisms underlying the associations between social stressors and cardiometabolic health across the life course is DNA methylation (DNAm). Recently a handful of small cross-sectional studies have found that stressful experiences may alter DNAm, thus providing a potential mechanism by which social stress may get under the skin. Most of the existing health research among Latinos has been specific to Latinos of Mexican origin. Latinos are not a homogenous group and while some Latinos are at greater risk of certain chronic conditions, other Latino groups may be at lower risk for certain conditions. Examining what factors may confer risk to some Latino ethnic groups or protect other Latino ethnic groups is crucial for developing interventions and informing decisions about resource allocation. We propose to examine the association between social and economic stressors, across the life course in relation to DNAm, as well as the rate of change of methylation and changes in cardiometabolic health, using existing data from the Hispanic Community Health Study /Study of Latinos (HCHS/SOL). The HCHS/SOL study is a longitudinal study of US Latinos, representing varied countries of origin, conducted in the US. We propose to use existing data from a stratified random sample of 500 men and 500 women, who completed an extensive set of socio-economic and stress measures in the HCHS/SOL Sociocultural Ancillary study and who provided blood samples at two different time points six years apart in adulthood. Existing blood samples will be assayed for genome-wide DNAm and DNAm age. Cardiometabolic health markers (obesity, diabetes, hypertension and lipids) have also been assessed at two time points. Existing data also includes repeated assessments of social and economic stressors and socio-cultural factors (i.e., nativity, familism, acculturation, social support). Specifically, we will examine 1) whether social and economic stressors in childhood and adulthood are associated with changes in DNAm age and genome-wide methylation over a 6-year period; 2) whether sociocultural factors modify the association between stressors and changes in DNAm and 3) whether DNAm is associated with changes in cardiometabolic health over a 6-year period. Upon completion of this project, our findings will advance understanding of how social and economic stressors shape epigenetic pathways, what factors may exacerbate or ameliorate these pathways and whether epigenetic changes over time influence cardiometabolic health changes.

拉丁美洲人是美国最大的少数民族群体，患有高血压的患病率很高， 在童年时期 与其他种族/族裔相比，成年。有广泛的证据表明经济和 社会压力塑造了心脏代谢健康的发展。但是，这在很大程度上未知 这些应激源会影响生物学过程，尤其是在细胞水平上。一种评估的新方法 社会压力源与心脏代谢健康之间关联的可能机制 在整个生命过程中，都是DNA甲基化（DNAM）。最近少数小的横断面研究 发现压力的经历可能会改变DNAM，从而提供了一种潜在的机制 社会压力可能会陷入皮肤之下。拉丁美洲人之间的大多数现有健康研究是具体的 到墨西哥起源的拉丁美洲人。拉丁美洲人不是同质群体，而某些拉丁裔则较大 某些慢性疾病的风险，其他拉丁裔群体在某些情况下可能处于较低的风险。检查 哪些因素可能会给某些拉丁裔族裔带来风险或保护其他拉丁裔族裔至关重要 用于制定干预措施并告知有关资源分配的决策。我们建议检查 社会压力源与经济压力之间的关联，与DNAN有关的生活课程以及 使用来自 西班牙裔社区健康研究 /拉丁裔研究（HCHS /SOL）。 HCHS/SOL研究是纵向 在美国进行的代表各种原籍国的美国拉丁美洲人的研究。我们建议使用 来自500名男性和500名女性的分层随机样本的现有数据，她们完成了广泛的套装 HCHS/SOL社会文化辅助研究中的社会经济和压力度量 成年后六年相隔六年的两个不同时间点的血液样本。现有的血液样本将是 分析了全基因组DNAN和DNAM时代的测定。心脏代谢健康标志物（肥胖，糖尿病， 高血压和脂质）也在​​两个时间点进行了评估。现有数据还包括重复 评估社会和经济压力源和社会文化因素（即耶稣降生，家庭主义， 适应，社会支持）。具体来说，我们将检查1）是否在 童年和成年与DNAM年龄和全基因组甲基化的变化有关 6年期； 2）社会文化因素是否改变了压力源与变化之间的关联 DNAN和3）DNAM是否与六年内心脏代谢健康的变化有关。 该项目完成后，我们的发现将进一步了解社会和经济方式 压力型塑造表观遗传途径，哪些因素可能加剧或改善这些途径，并且 表观遗传随着时间的变化是否会影响心脏代谢健康的变化。