Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience

围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 10472708
• 负责人: Marisa N Spann
• 金额: $ 16.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472708
• 关键词: Age; Anterior; Anxiety; Area; Attention; Autoimmune Diseases; Base of the Brain; Behavior Therapy; Behavioral; Behavioral Symptoms; Biological; Biological Markers; Blood Glucose; Body mass index; Brain; Brain region; Child; Childhood; Cognitive; Computerized Medical Record; Data; Data Collection; Data Pooling; Data Set; Development; Diagnosis; Dimensions; Distress; Dorsal; Early Diagnosis; Ensure; Funding; Funding Mechanisms; Future; Goals; Health; Health education; High Prevalence; Hydrocortisone; Image; Immune system; Infant; Infection; Inflammation; Insula of Reil; International; Intervention; Knowledge; Laboratories; Life Style; Link; Literature; Magnetic Resonance Imaging; Manuscripts; Maps; Medial; Mediating; Medical center; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Neonatal; Neurobiology; Neurosciences; Obesity; Outcome; Pathway interactions; Perinatal; Pilot Projects; Positioning Attribute; Prefrontal Cortex; Pregnancy; Pregnant Women; Procedures; Productivity; Program Development; Public Health; Regulation; Research; Research Domain Criteria; Research Personnel; Research Training; Resources; Risk; Rodent Model; Role; Salivary; Sampling; School-Age Population; Science; Scientist; Series; Stress; Structure; Symptoms; Thalamic structure; Time; Toddler; Training; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Work; advanced analytics; analytical method; antepartum depression; brain morphology; brain pathway; brain volume; career; career development; career networking; cingulate cortex; cohort; diabetes risk; environmental stressor; experience; fetal; health information technology; human model; hypothalamic-pituitary-adrenal axis; improved; indexing; interest; intergenerational; maternal depression; neuroimaging; next generation; obesity risk; offspring; patient oriented; patient oriented research; patient population; personalized approach; prenatal; prenatal exposure; prenatal health; prenatal influence; programs; psychiatric symptom; psychological distress; psychological stressor; research study; skills; socioeconomics; success

Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. Thus, a high number of children who would benefit from mental health care remain untreated. My long-term goal is to improve brain-based targets for early detection and behavioral interventions of childhood psychiatric disorders. The area of perinatal-developmental neuroscience (PDN) is of high public health significance as a substantial proportion of pregnant women will experience health, environmental, or psychological stressors, which have early and long-lasting effects on offspring. Increasing the number of research programs that can support training in PDN is paramount. The K24 will allow me to: 1) expand my expertise in advanced analytic methods to support trainee research, and 2) establish an internationally recognized research and training program focused on fetal-infant brain and behavioral origins of mental health. My K24 training program, the Columbia Engagement, Stability, and Success in PDN will provide an individualized approach to research training: assessing the research skills and career goals of mentees early on and developing personalized training modules; didactics; experiential, hands-on training; and research productivity that follow their individualized plan. The program also includes a monthly seminar series alternating between science and career-networking topics. Our prior studies suggest there may be common biological pathways by which early exposures exert their influence on offspring conferring psychiatric risk – with recent attention to the immune system and/or hypothalamic-pituitary-adrenal axis, and brain regions involved in behavioral regulation. Using the expanded analytic skills obtained through this K24, my mentees and I will conduct studies to examine whether four key prenatal exposures: maternal depression, body mass index, infection, and blood glucose are associated with connectivity and morphology of brain regions (e.g., dorsal anterior cingulate) involved in behavioral regulation. In a subset of the cohort, we will also consider the potential mediating effects of inflammation and glucocorticosteriods. I have a unique opportunity to pool data from cohorts of pregnant women-fetal dyads involved in research studies (2004 to present; n~500) at Columbia University Irving Medical Center – a large center with a diverse patient population – and perform new data collection harnessing health information technology (e.g., electronic medical records). The data set will serve as a platform for my mentees to produce pilot projects and manuscripts, and practical experience conducting a project in an area of PDN that matches his/her career goals within the scope of this funding mechanism. My strong commitment to and ongoing research in patient-oriented research focused on identifying early antecedents of psychiatric risk, individualized mentorship plans, direct involvement of mentees in the conduct of research, and tailored career development program at Columbia University Irving Medical Center are strengths of this application. The K24 mentees will be uniquely positioned to discover neurobiological and behavioral pathways associated with risk.

尽管有证据表明有五分之一的孩子有精神疾病的风险，但只有二十个年幼的儿童中只有1个 心理保健。这是，从精神卫生保健中受益的大量儿童仍未得到治疗。 我的长期目标是改善童年的早期发现和行为干预措施的基于大脑的目标 精神疾病。围产期开发神经科学（PDN）的区域高公共卫生 重要的意义是很大一部分孕妇将体验健康，环境或 心理压力源对后代具有早期和持久的影响。增加数量 可以支持PDN培训的研究计划至关重要。 K24将允许我：1）扩展我的 高级分析方法的专业知识以支持受训者研究，2）在国际上建立一个 公认的研究和培训计划着重于胎儿的大脑和心理健康的行为起源。 我的K24培训计划，哥伦比亚的参与度，稳定和PDN的成功将提供个性化的 研究培训方法：早期和开发评估月经的研究技能和职业目标 个性化培训模块；教学法;专家，动手培训；以及随后的研究生产力 他们的个性化计划。该计划还包括一个每月的开创性系列，在科学和 职业网络主题。我们先前的研究表明，早期可能存在常见的生物学途径 暴露对后代会议精神病风险产生影响 - 最近关注免疫 系统和/或下丘脑 - 垂体 - 肾上腺轴以及涉及行为调节的大脑区域。使用 通过此K24获得的扩大分析技能，我和我的月经都将进行研究，以检查是否是否 四个关键的产前暴露：物物抑郁症，体重指数，感染和血糖相关 与行为涉及的大脑区域的连通性和形态 规定。在队列的一部分中，我们还将考虑感染和 糖皮质肌植物。我有一个独特的机会来汇总孕妇二元组的同类数据 参与研究研究（2004年； n〜500），哥伦比亚大学欧文医学中心 以潜水员的居民为中心 - 并执行新的数据收集来利用健康信息 技术（例如电子病历）。数据集将作为我的Menees生产的平台 试点项目和手稿，以及在PDN领域进行项目的实践经验 他/她的职业目标在这种融资机制的范围内。我对正在进行的研究的坚定承诺 在以患者为导向的研究中，重点是确定精神病风险的早期先例 识别计划，直接参与研究的研究以及量身定制的职业发展 哥伦比亚大学欧文医学中心的计划是该应用程序的优势。 K24男士将是 独特的位置可以发现与风险相关的神经生物学和行为途径。